解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver...
journal_title:Journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1007/s11418-021-01484-3
更新日期:2021-01-22 00:00:00
abstract::Autophagy is a catabolic process for degradation of intracellular components and plays an important role in the development and growth of cancer. Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the proliferation of HepG2 hepatocellular carcinoma cells and inhi...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-020-01462-1
更新日期:2021-01-01 00:00:00
abstract::Chemotherapy-induced peripheral neuropathy (CIPN) manifests as mechanical allodynia and hyperalgesia, and is one of the main adverse effects of chemotherapeutic agents. Currently available therapeutic drugs are not sufficiently effective for the management of this adverse effect in the clinic. Therefore, the developme...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-020-01441-6
更新日期:2021-01-01 00:00:00
abstract::A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenet...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-020-01457-y
更新日期:2021-01-01 00:00:00
abstract::Isoorientin (ISO), a natural flavonoid compound, has been identified in several plants and its biological activity is determined and the study on lowering uric acid has not been reported. In view of the current status of treatment of hyperuricemia, we evaluated the hypouricemic effects of ISO in vivo and in vitro, and...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-020-01464-z
更新日期:2021-01-01 00:00:00
abstract::Oligostilbenoids are a group of natural products derived from the oxidative coupling of C6-C2-C6 units found in some plant families. A structurally diverse chemical pool is produced after the successive regioselective and stereoselective oligomerization of resveratrol. This review describes the current status and know...
journal_title:Journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1007/s11418-020-01412-x
更新日期:2020-09-01 00:00:00
abstract::Cancer cachexia is a complex and multifactorial syndrome that influences about 50-80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal m...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-020-01428-3
更新日期:2020-09-01 00:00:00
abstract::Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xant...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01376-7
更新日期:2020-03-01 00:00:00
abstract::The predominant feature of type 2 diabetes is insulin resistance. Identifying a drug able to reduce insulin resistance is an urgent requirement. ent-3α-Formylabieta-8(14),13(15)-dien-16,12β-olide had been identified as a new diterpene derivative which showed anticancer activity. This study explores the hypoglycemic ef...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01384-7
更新日期:2020-03-01 00:00:00
abstract::It is generally accepted that fungi have a number of dormant gene clusters for the synthesis of secondary metabolites, and the activation of these gene clusters can expand the diversity of secondary metabolites in culture. Recent studies have revealed that the mycolic acid-containing bacterium Tsukamurella pulmonis ac...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01345-0
更新日期:2020-01-01 00:00:00
abstract::Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01368-7
更新日期:2020-01-01 00:00:00
abstract::The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01357-w
更新日期:2020-01-01 00:00:00
abstract::Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of the adipose tissue that leads to metabolic disorders, such as insulin resistance and type 2 diabetes mellitus. The regulation of immune cell infiltration into adipose tissue has prophylactic and t...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01332-5
更新日期:2020-01-01 00:00:00
abstract::To date, there are very few effective drugs for liver fibrosis treatment; therefore, it is urgent to develop novel therapeutic targets and approaches. In the present research, we sought to study the protective effect of sweroside contained in Lonicera japonica or blue honeysuckle berries in a mouse model of liver fibr...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01334-3
更新日期:2020-01-01 00:00:00
abstract::Three new compounds, (3S)-dihydrobonducellin 8-O-β-D-glucopyranoside (1), 3',5'-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01335-2
更新日期:2020-01-01 00:00:00
abstract::Four new cucurbitane-type triterpenes were isolated from the fruit of Momordica charantia L. The structures of the new compounds were identified based on HR-ESI-MS and 1D- and 2D-NMR spectroscopic methods. The cytotoxicity of the isolated compounds was evaluated using three human cancer cell lines, HeLa, Caco2, and U8...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01336-1
更新日期:2020-01-01 00:00:00
abstract::Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01326-3
更新日期:2019-09-01 00:00:00
abstract::Pueraria candollei (P. candollei) is a traditional Thai herb widely used for estrogen replacement therapy because it contains many unique chromenes that possess potent estrogenic activity, one of which is known as isomiroestrol. Since isomiroestrol is a promising compound that is solely present in P. candollei, it can...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01307-6
更新日期:2019-06-01 00:00:00
abstract::Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01289-5
更新日期:2019-06-01 00:00:00
abstract::A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolu...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01313-8
更新日期:2019-06-01 00:00:00
abstract::Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-01279-z
更新日期:2019-06-01 00:00:00
abstract::A new depsidone, paucinervin Q (1), a new dichromone, paucinervin R (2), and a known compound, paucinervin B (3), were isolated from the stems of Garcinia paucinervis by various chromatographic methods. Their structures were determined by analysis of spectroscopic data. The isolates were evaluated for their antiprolif...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1247-1
更新日期:2019-01-01 00:00:00
abstract::Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (4-25) were obtained from the 70% ethanol-water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods. Among the known compounds, 14, 15, 17 and 23 were firstly obtained from ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1255-1
更新日期:2019-01-01 00:00:00
abstract::Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1231-9
更新日期:2019-01-01 00:00:00
abstract::Ephedra Herb is a crude drug defined as the terrestrial stem of Ephedra sinica, E. intermedia, or E. equisetina. It is often used to treat headaches, bronchial asthma, nasal inflammation, and the common cold. In this study, we isolated characteristic non-alkaloidal constituents from the extracts and identified them in...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1265-z
更新日期:2019-01-01 00:00:00
abstract::Three new acetylated C-glycosylflavones, 3″,6″-di-O-acetylswertiajaponin (1), 4″,6″-di-O-acetylswertiajaponin (2), and 6″-O-acetylswertiajaponin (3), together with six known compounds were isolated from the whole herb of Swertia mileensis. Their structures were elucidated on extensive NMR experiments and mass spectrom...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1225-7
更新日期:2018-09-01 00:00:00
abstract::The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharm...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1190-1
更新日期:2018-06-01 00:00:00
abstract::Ginkgo biloba L. has been used as a herbal medicine in the traditional treatment of insufficient blood flow, memory deficits, and cerebral insufficiency. The terpene trilactone components, the bioactive agents of Ginkgo biloba L., have also been reported to exhibit useful functionality such as anti-inflammatory and ne...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1203-0
更新日期:2018-06-01 00:00:00
abstract::In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF)...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1175-0
更新日期:2018-03-01 00:00:00
abstract::The article Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, written by Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma and Takashi Hakamatsuka, was originally published Online First with...
journal_title:Journal of natural medicines
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11418-018-1195-9
更新日期:2018-03-01 00:00:00
abstract::Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dieno...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1181-2
更新日期:2018-03-01 00:00:00
abstract::Ceramicines are a series of limonoids which were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and show various biological activities. Ceramicine B, in particular, has been reported to show a strong lipid droplet accumulation (LDA) inhibitory activity on a mouse pre-adipocyte cell line (MC3T3-G...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1109-2
更新日期:2018-01-01 00:00:00
abstract::In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1119-0
更新日期:2018-01-01 00:00:00
abstract::Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1122-5
更新日期:2018-01-01 00:00:00
abstract::Twenty-three new C21 steroidal glycosides, marstenacissides C1-C10 (1-10), D1-D7 (11-17) and E1-E6 (18-23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), w...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1126-1
更新日期:2018-01-01 00:00:00
abstract::Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihyd...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1125-2
更新日期:2018-01-01 00:00:00
abstract::Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1-2) with six known congeners (3-8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit throu...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1141-2
更新日期:2018-01-01 00:00:00
abstract::The binding properties of recombinant antibody fragments, such as affinity and specificity, determine their usefulness for therapeutic and analytical applications. Anti-paclitaxel single-chain variable fragment clone 1C2 (anti-PT scFv1C2) was expressed using Escherichia coli cell and Bombyx mori larvae expression syst...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1136-z
更新日期:2018-01-01 00:00:00
abstract::Phellodendri Cortex (Obaku in Japanese) and Coptidis Rhizoma (Oren), both of which contain berberine, have been used to prepare the kampo formula orengedokuto to treat inflammatory diseases, including dermatitis, gastric ulcers, and gastritis. These drugs are blended differently in other formulas, such as the use of P...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1107-4
更新日期:2017-10-01 00:00:00
abstract::A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1081-x
更新日期:2017-07-01 00:00:00