C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity.

abstract：:Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, ath...

journal_title：Journal of natural medicines

authors： Abdallah HM,El-Bassossy HM,Mohamed GA,El-Halawany AM,Alshali KZ,Banjar ZM

更新日期：2017-01-01 00:00:00

abstract：:Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring c...

journal_title：Journal of natural medicines

authors： Makihara H,Shimada T,Machida E,Oota M,Nagamine R,Tsubata M,Kinoshita K,Takahashi K,Aburada M

更新日期：2012-07-01 00:00:00

abstract：:Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in...

journal_title：Journal of natural medicines

authors： Nagakura Y,Nugroho AE,Hirasawa Y,Hosoya T,Rahman A,Kusumawati I,Zaini NC,Morita H

更新日期：2013-04-01 00:00:00

abstract：:Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...

journal_title：Journal of natural medicines

authors： Prema,Wong CP,Nugroho AE,Awouafack MD,Win YY,Win NN,Ngwe H,Morita H,Morita H

更新日期：2019-06-01 00:00:00

abstract：:Shakuyakukanzoto (SKT) is a kampo medicine composed of equal proportions of Glycyrrhizae radix (G. radix) and Paeoniae radix (P. radix). A double-blind study reported that SKT significantly ameliorated painful muscle cramp in cirrhosis patients without the typical severe side effects of muscle weakness and central ner...

journal_title：Journal of natural medicines

authors： Kaifuchi N,Omiya Y,Kushida H,Fukutake M,Nishimura H,Kase Y

更新日期：2015-07-01 00:00:00

abstract：:Pine needle extract (PE) and fermented pine needle extract (FPE) have been reported to show various biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, gastrointestinal motility control, and fibrinolytic effect. The aims of our research were to isolate fi...

journal_title：Journal of natural medicines

authors： Park J,Lee B,Choi H,Kim W,Kim HJ,Cheong H

更新日期：2016-07-01 00:00:00

abstract：:Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation...

journal_title：Journal of natural medicines

authors： Khan M,Khan AU,Najeeb-ur-Rehman,Gilani AH

更新日期：2012-04-01 00:00:00

abstract：:I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver...

journal_title：Journal of natural medicines

authors： Makino T

更新日期：2021-01-22 00:00:00

abstract：:Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous studies with β-PGG revealed a wide variety of biological activities, such as anti-microbial and an...

journal_title：Journal of natural medicines

authors： Cao Y,Himmeldirk KB,Qian Y,Ren Y,Malki A,Chen X

更新日期：2014-07-01 00:00:00

abstract：:Although Radix Angelicae dahuricae (Angelica) has been traditionally used in patients with rheumatism arthralgia, its bioactive ingredients remain to be determined. In this study, the essential oil extract of Radix Angelicae dahuricae (EOAD) was assessed for its anti-inflammatory activities against xylene-induced acut...

journal_title：Journal of natural medicines

authors： Wang C,Sun J,Li H,Yang X,Liu H,Chen J

更新日期：2016-07-01 00:00:00

abstract：:Two novel monoterpenes, sibiscolacton (1) and sibiraic acid (2), were isolated from the aerial part of Sibiraea angustata RCHD: . along with seven known compounds, namely three phenylpropanoids (3-5), two flavonoids (6,7), one glucityl ferulate (8, sibirate), and a monoterpene glucoside (9, sibiskoside). The structure...

journal_title：Journal of natural medicines

authors： Li B,Lee JB,Hayashi K,Ito Y,Sun WJ,Wang X,Kano Y,Hayashi T

更新日期：2010-01-01 00:00:00

abstract：:The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ...

journal_title：Journal of natural medicines

authors： Chen H,Olatunji OJ,Zhou Y

更新日期：2016-07-01 00:00:00

abstract：:A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...

journal_title：Journal of natural medicines

authors： Sugimoto S,Yamano Y,Khalil HE,Otsuka H,Kamel MS,Matsunami K

更新日期：2017-07-01 00:00:00

abstract：:The article Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, written by Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma and Takashi Hakamatsuka, was originally published Online First with...

journal_title：Journal of natural medicines

authors： Nose M,Tada M,Kojima R,Nagata K,Hisaka S,Masada S,Homma M,Hakamatsuka T

更新日期：2018-03-01 00:00:00

abstract：:Autophagy is a catabolic process for degradation of intracellular components and plays an important role in the development and growth of cancer. Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the proliferation of HepG2 hepatocellular carcinoma cells and inhi...

journal_title：Journal of natural medicines

authors： Okubo S,Ohta T,Fujita H,Shoyama Y,Uto T

更新日期：2021-01-01 00:00:00

abstract：:Ginkgo biloba L. has been used as a herbal medicine in the traditional treatment of insufficient blood flow, memory deficits, and cerebral insufficiency. The terpene trilactone components, the bioactive agents of Ginkgo biloba L., have also been reported to exhibit useful functionality such as anti-inflammatory and ne...

journal_title：Journal of natural medicines

authors： Liang T,Miyakawa T,Yang J,Ishikawa T,Tanokura M

更新日期：2018-06-01 00:00:00

abstract：:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...

journal_title：Journal of natural medicines

authors： Yano M,Nakashima S,Oda Y,Nakamura S,Matsuda H

更新日期：2020-01-01 00:00:00

abstract：:Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihyd...

journal_title：Journal of natural medicines

authors： Ban NK,Thoa NTK,Linh TM,Trang DT,Van Kiem P,Nhiem NX,Tai BH,Van Minh C,Song JH,Ko HJ,Kim SH

更新日期：2018-01-01 00:00:00

abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...

journal_title：Journal of natural medicines

authors： Takemoto H,Ito M,Shiraki T,Yagura T,Honda G

更新日期：2008-01-01 00:00:00

abstract：:A new diterpenoid was isolated from the leaves of Clerodendron trichotomumThunb. (Verbenaceae) along with one each of a known diterpenoid, phenylethanoid glycoside, and sterol and two known flavonoids. Their chemical structures were characterized on the basis of spectroscopic data and X-ray analysis. In addition, thei...

journal_title：Journal of natural medicines

authors： Ono M,Furusawa C,Matsumura K,Noguchi S,Yasuda S,Okawa M,Kinjo J,Eto M,Yamaguchi K,Yoshimitsu H,Nohara T

更新日期：2013-04-01 00:00:00

abstract：:Since prostate growth is governed by the androgen signaling pathway, blockade of the pathway is regarded as an appropriate strategy for the treatment of benign prostatic hyperplasia (BPH). Panax ginseng is known to have various pharmacological activities. Of several products of its root, red ginseng, having many bioac...

journal_title：Journal of natural medicines

authors： Bae JS,Park HS,Park JW,Li SH,Chun YS

更新日期：2012-07-01 00:00:00

abstract：:Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the ...

journal_title：Journal of natural medicines

authors： Narukawa Y,Komori M,Niimura A,Noguchi H,Kiuchi F

更新日期：2015-01-01 00:00:00

abstract：:An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...

journal_title：Journal of natural medicines

authors： Hasuda T,Hitotsuyanagi Y,Takeya K

更新日期：2011-07-01 00:00:00

abstract：:Curcuma comosa is widely used as a traditional herbal medicine for gynecological diseases in South East Asia. Previous studies reported that it has phytoestrogenic activity, and several diarylheptanoids were found to be the active constituents. In this study, the pharmacokinetics profile and organ distribution of thre...

journal_title：Journal of natural medicines

authors： Su J,Sripanidkulchai K,Suksamrarn A,Hu Y,Piyachuturawat P,Sripanidkulchai B

更新日期：2012-07-01 00:00:00

abstract：:Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect ...

journal_title：Journal of natural medicines

authors： Morihara N,Hino A

更新日期：2017-01-01 00:00:00

abstract：:Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of the adipose tissue that leads to metabolic disorders, such as insulin resistance and type 2 diabetes mellitus. The regulation of immune cell infiltration into adipose tissue has prophylactic and t...

journal_title：Journal of natural medicines

authors： Tsuhako R,Yoshida H,Sugita C,Kurokawa M

更新日期：2020-01-01 00:00:00

abstract：:Three new acetylated C-glycosylflavones, 3″,6″-di-O-acetylswertiajaponin (1), 4″,6″-di-O-acetylswertiajaponin (2), and 6″-O-acetylswertiajaponin (3), together with six known compounds were isolated from the whole herb of Swertia mileensis. Their structures were elucidated on extensive NMR experiments and mass spectrom...

journal_title：Journal of natural medicines

authors： Liu X,Shi Y,Hu H,Li J,Li C,Yang L,Wang Z

更新日期：2018-09-01 00:00:00

abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...

journal_title：Journal of natural medicines

authors： Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki T

更新日期：2011-07-01 00:00:00

abstract：:Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...

journal_title：Journal of natural medicines

authors： Yang D,Li L,Qian S,Liu L

更新日期：2018-01-01 00:00:00

abstract：:Rosae fructus is a traditional Chinese crude drug, used for purgative purposes. It is included in the Japanese Pharmacopoeia XV, in which its origin is stated to be Rosa multiflora Thunberg. These days, some imported Rosae fructus are on the market and the pharmacological activity of the imported product is in questio...

journal_title：Journal of natural medicines

authors： Kawakami S,Matsunami K,Otsuka H,Kawahata M,Yamaguchi K

更新日期：2009-01-01 00:00:00