C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity.

Abstract:

:Twenty-three new C21 steroidal glycosides, marstenacissides C1-C10 (1-10), D1-D7 (11-17) and E1-E6 (18-23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), were isolated from the Dai herbal medicine Dai-Bai-Jie, derived from the roots of Marsdenia tenacissima. The chemical structures of all compounds were established by spectroscopic techniques, including high-resolution mass spectrometry and NMR spectroscopy, as well as by comparison with reported spectral data. The anti-HIV activities of these compounds were screened, and the compounds obtained displayed inhibitory effects against HIV-1 with inhibition rates of 36.4-81.3% at 30 μM.

journal_name

J Nat Med

authors

Pang X,Kang LP,Fang XM,Yu HS,Han LF,Zhao Y,Zhang LX,Yu LY,Ma BP

doi

10.1007/s11418-017-1126-1

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

166-180

issue

1

eissn

1340-3443

issn

1861-0293

pii

10.1007/s11418-017-1126-1

journal_volume

72

pub_type

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