Rosmarinic acid in Argusia argentea inhibits snake venom-induced hemorrhage.

abstract：:Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect ...

journal_title：Journal of natural medicines

authors： Morihara N,Hino A

更新日期：2017-01-01 00:00:00

abstract：:Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. O...

journal_title：Journal of natural medicines

authors： Pan Y,Tiong KH,Abd-Rashid BA,Ismail Z,Ismail R,Mak JW,Ong CE

更新日期：2014-04-01 00:00:00

abstract：:A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolu...

journal_title：Journal of natural medicines

authors： Wu C,He L,Yi X,Qin J,Li Y,Zhang Y,Wang G

更新日期：2019-06-01 00:00:00

abstract：:Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...

journal_title：Journal of natural medicines

authors： Yang D,Li L,Qian S,Liu L

更新日期：2018-01-01 00:00:00

abstract：:A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falcip...

journal_title：Journal of natural medicines

authors： Nugroho AE,Hirasawa Y,Piow WC,Kaneda T,Hadi AH,Shirota O,Ekasari W,Widyawaruyanti A,Morita H

更新日期：2012-04-01 00:00:00

abstract：:Several studies have indicated the involvement of oxidative stress and high glucose-induced cell death in the development of diabetic neuropathy. Satureja khuzestanica has been recommended in the literature as a remedy for the treatment of diabetes, and also contains antioxidant agents. Here, we investigated the possi...

journal_title：Journal of natural medicines

authors： Kaeidi A,Esmaeili-Mahani S,Abbasnejad M,Sheibani V,Rasoulian B,Hajializadeh Z,Pasban-Aliabadi H

更新日期：2013-01-01 00:00:00

abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...

journal_title：Journal of natural medicines

authors： Salla M,Fakhoury I,Saliba N,Darwiche N,Gali-Muhtasib H

更新日期：2013-07-01 00:00:00

abstract：:Species of genus Ocimum (Lamiaceae) are economically important due to their essential oils and utilization as medicine for many disorders, including the central nervous system. A previous study showed seasonal variations in chemical profile and in central nervous system activities of essential oil from Ocimum gratissi...

journal_title：Journal of natural medicines

authors： Galindo LA,Pultrini Ade M,Costa M

更新日期：2010-10-01 00:00:00

abstract：:To date, there are very few effective drugs for liver fibrosis treatment; therefore, it is urgent to develop novel therapeutic targets and approaches. In the present research, we sought to study the protective effect of sweroside contained in Lonicera japonica or blue honeysuckle berries in a mouse model of liver fibr...

journal_title：Journal of natural medicines

authors： Gong J,Yang F,Yang Q,Tang X,Shu F,Xu L,Wang Z,Yang L

更新日期：2020-01-01 00:00:00

abstract：:Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in...

journal_title：Journal of natural medicines

authors： Nagakura Y,Nugroho AE,Hirasawa Y,Hosoya T,Rahman A,Kusumawati I,Zaini NC,Morita H

更新日期：2013-04-01 00:00:00

abstract：:Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eigh...

journal_title：Journal of natural medicines

authors： Rahman AK,Chowdhury AK,Ali HA,Raihan SZ,Ali MS,Nahar L,Sarker SD

更新日期：2009-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...

journal_title：Journal of natural medicines

authors： Hisayoshi T,Shinomura M,Yokokawa K,Kuze I,Konishi A,Kawaji K,Kodama EN,Hata K,Takahashi S,Nirasawa S,Sakuda S,Yasukawa K

更新日期：2015-07-01 00:00:00

abstract：:In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components. ...

journal_title：Journal of natural medicines

authors： Hosoi S,Shimizu E,Arimori K,Okumura M,Hidaka M,Yamada M,Sakushima A

更新日期：2008-07-01 00:00:00

abstract：:An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...

journal_title：Journal of natural medicines

authors： Hasuda T,Hitotsuyanagi Y,Takeya K

更新日期：2011-07-01 00:00:00

abstract：:Four new Amaryllidaceae alkaloids (1-4) possessing a homolycorine-type or a crinine-type skeleton have been isolated from the aerial part of Zephyranthes candida, and their structures were elucidated on the basis of spectroscopic data. The stereochemistry was elucidated by combination of NOESY correlations and CD anal...

journal_title：Journal of natural medicines

authors： Shitara N,Hirasawa Y,Hasumi S,Sasaki T,Matsumoto M,Wong CP,Kaneda T,Asakawa Y,Morita H

更新日期：2014-07-01 00:00:00

abstract：:This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory a...

journal_title：Journal of natural medicines

authors： Zakaria ZA,Ghani ZD,Nor RN,Gopalan HK,Sulaiman MR,Jais AM,Somchit MN,Kader AA,Ripin J

更新日期：2008-04-01 00:00:00

abstract：:Taxol is produced by a few microorganisms and plants such as yew (Taxus sp.). Recent researches have shown that hazel (Corylus avellana L.) is also able to produce Taxol. In the present study, effects of different concentrations of phenylalanine (Phe) on the production of Taxol, antioxidant activity, and cytotoxic eff...

journal_title：Journal of natural medicines

authors： Bemani E,Ghanati F,Rezaei A,Jamshidi M

更新日期：2013-07-01 00:00:00

abstract：:Oligostilbenoids are a group of natural products derived from the oxidative coupling of C6-C2-C6 units found in some plant families. A structurally diverse chemical pool is produced after the successive regioselective and stereoselective oligomerization of resveratrol. This review describes the current status and know...

journal_title：Journal of natural medicines

authors： Ito T

更新日期：2020-09-01 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy (CIPN) manifests as mechanical allodynia and hyperalgesia, and is one of the main adverse effects of chemotherapeutic agents. Currently available therapeutic drugs are not sufficiently effective for the management of this adverse effect in the clinic. Therefore, the developme...

journal_title：Journal of natural medicines

authors： Yu H,Toume K,Kurokawa Y,Andoh T,Komatsu K

更新日期：2021-01-01 00:00:00

abstract：:The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ...

journal_title：Journal of natural medicines

authors： Chen H,Olatunji OJ,Zhou Y

更新日期：2016-07-01 00:00:00

abstract：:Aconitum vilmorinianum Komarov is a local medicinal plant used in many well-known clinical preparations to treat rheumatism and pains in Yunnan Province, China. Phytochemical examination of the roots of A. vilmorinianum led to the isolation of three novel imine-type norditerpenoid alkaloids named vilmorrianines E-G (1...

journal_title：Journal of natural medicines

authors： Chen CL,Tan WH,Wang Y,Xue ZG,Wan CP,Yang ZY,Zhou ZH,Ma XX

更新日期：2015-10-01 00:00:00

abstract：:Three new acetylated C-glycosylflavones, 3″,6″-di-O-acetylswertiajaponin (1), 4″,6″-di-O-acetylswertiajaponin (2), and 6″-O-acetylswertiajaponin (3), together with six known compounds were isolated from the whole herb of Swertia mileensis. Their structures were elucidated on extensive NMR experiments and mass spectrom...

journal_title：Journal of natural medicines

authors： Liu X,Shi Y,Hu H,Li J,Li C,Yang L,Wang Z

更新日期：2018-09-01 00:00:00

abstract：:This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...

journal_title：Journal of natural medicines

authors： Ebrahim AM,Eltayeb MH,Khalid H,Mohamed H,Abdalla W,Grill P,Michalke B

更新日期：2012-10-01 00:00:00

abstract：:Five new coumarins, (+)-peujaponisin (1) and multivittans A-D (2-5), were isolated from the roots of Ligusticum multivittatum Franch., and their structures were established by spectral means. ...

journal_title：Journal of natural medicines

authors： Kondo T,Taniguchi M,Shibano M,Wang NH,Baba K

更新日期：2008-01-01 00:00:00

abstract：:Acanthopanax senticosus HARMS (AS) is used as a Chinese herbal medicine and as a health supplement in Japan. However, little is known about the interaction between AS and other drugs. In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporte...

journal_title：Journal of natural medicines

authors： Takahashi T,Kaku T,Sato T,Watanabe K,Sato J

更新日期：2010-01-01 00:00:00

abstract：:Pine needle extract (PE) and fermented pine needle extract (FPE) have been reported to show various biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, gastrointestinal motility control, and fibrinolytic effect. The aims of our research were to isolate fi...

journal_title：Journal of natural medicines

authors： Park J,Lee B,Choi H,Kim W,Kim HJ,Cheong H

更新日期：2016-07-01 00:00:00

abstract：:Near-infrared (NIR) spectroscopy combined with chemometrics has been utilized in predictions of natural medicine content without destroying samples. Suppositories (oren powdered extract content 0, 0.5, 1.0, 2.5, 10, 12.5, and 15%) were produced by mixing oren powdered extract with macrogol mixture consisting of 1 part...

journal_title：Journal of natural medicines

authors： Teraoka R,Abe H,Sugama T,Ito K,Aburada M,Otsuka M

更新日期：2012-04-01 00:00:00

abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...

journal_title：Journal of natural medicines

authors： Xiong H,Zhao F,Bi J,Zhang Y,Zhao G,Chen X,Li Y,Yan R,Zhao Q,Qiao H,Zhang G

更新日期：2016-07-01 00:00:00

abstract：:The aim of the study was to investigate the in vivo effect of the seashell protein Haishengsu (HSS) on Ehrlich ascites tumor. Mice were inoculated with Ehrlich ascites tumor cells and randomly divided into three HSS groups and a control group. The survival times in the three HSS-treated groups was longer than in the c...

journal_title：Journal of natural medicines

authors： Liu JZ,Chen SG,Bin Z,Wang CB,Li GY,Wang LX

更新日期：2009-10-01 00:00:00

abstract：:Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as r...

journal_title：Journal of natural medicines

authors： Ninomiya K,Motai C,Nishida E,Kitagawa N,Yoshihara K,Hayakawa T,Muraoka O,Li X,Nakamura S,Yoshikawa M,Matsuda H,Morikawa T

更新日期：2016-07-01 00:00:00