Abstract:
:Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect of AGE on the functional property of platelet by administering AGE to rats and evaluating the platelet aggregation in response to collagen in vitro. We found that AGE treatment significantly reduced the ability of platelet to aggregate and this effect of AGE was manifested on the 14 day, but not 7 day of treatment. In addition, AGE treatment produced platelets that responded to collagen by significantly increasing the amount of both the extracellular ATP and the extra- and intracellular TXB2. AGE treatment also dose-dependently suppressed the phosphorylation of collagen-induced ERK, p38 and JNK. However, AGE administration did not affect the bleeding time. These findings suggest that AGE treatment results in suppression of platelet aggregation by changing the functional property of platelets to respond to collagen.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Morihara N,Hino Adoi
10.1007/s11418-016-1055-4subject
Has Abstractpub_date
2017-01-01 00:00:00pages
249-256issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-016-1055-4journal_volume
71pub_type
杂志文章abstract::This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...
journal_title:Journal of natural medicines
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doi:10.1007/s11418-012-0630-6
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-016-0991-3
更新日期:2016-07-01 00:00:00
abstract::The purpose of the present study was to investigate the protective effects of combined therapy of garlic homogenate and hydrochlorothiazide (HCTZ) in animals with hypertension and myocardial damage. Three weeks of high fructose (10% w/v) in fluid to albino rats resulted in hypertension. They were subsequently administ...
journal_title:Journal of natural medicines
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doi:10.1007/s11418-010-0467-9
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abstract::Poria, a dried sclerotium of Wolfiporia cocos Ryvarden et Gilbertson (Polyporaceae) has been used as a crude drug in both Chinese and Japanese (Kampo) traditional medicines. Recently, cultivated products of Chinese Poria strains have accounted for most of the market, while the cultivation of Ja...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章,评审
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-011-0508-z
更新日期:2011-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-010-0458-x
更新日期:2011-01-01 00:00:00
abstract::The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...
journal_title:Journal of natural medicines
pub_type: 信件
doi:10.1007/s11418-009-0318-8
更新日期:2009-07-01 00:00:00
abstract::Euphorbia hirta L. has been widely used in India and Chinese society. The molecular pharmacology basis of its anti-inflammatory effect is revealed in this work. The ethanol extract of Euphorbia hirta L. (Eh) and its active component were studied in lipopolysaccharide (LPS)-activated macrophage cells (RAW 264.7) as an ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-010-0417-6
更新日期:2010-07-01 00:00:00