Two new diterpenoids from Leonotis leonurus R. Br.

abstract：:It has been found by ribosomal DNA analysis that the endophytic filamentous fungi isolated from the tea plant Camellia sinensis (Theaceae) are composed of six groups; one Fusarium sp., one Penicillium sp., two Schizophyllum sp., and two Diaporthe sp.. ...

journal_title：Journal of natural medicines

authors： Agusta A,Ohashi K,Shibuya H

更新日期：2006-07-01 00:00:00

abstract：:Curcuma comosa is widely used as a traditional herbal medicine for gynecological diseases in South East Asia. Previous studies reported that it has phytoestrogenic activity, and several diarylheptanoids were found to be the active constituents. In this study, the pharmacokinetics profile and organ distribution of thre...

journal_title：Journal of natural medicines

authors： Su J,Sripanidkulchai K,Suksamrarn A,Hu Y,Piyachuturawat P,Sripanidkulchai B

更新日期：2012-07-01 00:00:00

abstract：:This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine coronary arterial rings, suspended in tissue baths filled with K...

journal_title：Journal of natural medicines

authors： Shah AJ,Gilani AH

更新日期：2012-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...

journal_title：Journal of natural medicines

authors： Hisayoshi T,Shinomura M,Yokokawa K,Kuze I,Konishi A,Kawaji K,Kodama EN,Hata K,Takahashi S,Nirasawa S,Sakuda S,Yasukawa K

更新日期：2015-07-01 00:00:00

abstract：:Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dieno...

journal_title：Journal of natural medicines

authors： Suyama Y,Tanaka N,Kawazoe K,Murakami K,Li SL,Sun HD,Kashiwada Y

更新日期：2018-03-01 00:00:00

abstract：:Acanthopanax senticosus HARMS (AS) is used as a Chinese herbal medicine and as a health supplement in Japan. However, little is known about the interaction between AS and other drugs. In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporte...

journal_title：Journal of natural medicines

authors： Takahashi T,Kaku T,Sato T,Watanabe K,Sato J

更新日期：2010-01-01 00:00:00

abstract：:The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...

journal_title：Journal of natural medicines

authors： Tang R,Kimishima A,Ishida R,Setiawan A,Arai M

更新日期：2020-01-01 00:00:00

abstract：:Species of genus Ocimum (Lamiaceae) are economically important due to their essential oils and utilization as medicine for many disorders, including the central nervous system. A previous study showed seasonal variations in chemical profile and in central nervous system activities of essential oil from Ocimum gratissi...

journal_title：Journal of natural medicines

authors： Galindo LA,Pultrini Ade M,Costa M

更新日期：2010-10-01 00:00:00

abstract：:An acyclic diterpene (plaunotol; 1) and two furanoditerpenes (plaunolide, 2 and plaunol E, 3), were isolated from Croton stellatopilosus leaves, and assessed for their inhibitory activity on nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 cells. Plaunotol, plaunolide and plaunol E exhibited i...

journal_title：Journal of natural medicines

authors： Premprasert C,Tewtrakul S,Plubrukarn A,Wungsintaweekul J

更新日期：2013-01-01 00:00:00

abstract：:The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...

journal_title：Journal of natural medicines

authors： Kitaoka F,Kakiuchi N,Long C,Itoga M,Yoshimatsu H,Mitsue A,Atsumi T,Mouri C,Mikage M

更新日期：2009-07-01 00:00:00

abstract：:The present study was designed to determine the protective effects of Yucca schidigera (Ys) against oxidative damage induced by acute nitrite intoxication as well as the histopathological evaluation of Ys in rats. The rats were divided into three groups each containing 12 rats: control (C); nitrite intoxication (N); Y...

journal_title：Journal of natural medicines

authors： Cigerci IH,Fidan AF,Konuk M,Yuksel H,Kucukkurt I,Eryavuz A,Sozbilir NB

更新日期：2009-07-01 00:00:00

abstract：:In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components. ...

journal_title：Journal of natural medicines

authors： Hosoi S,Shimizu E,Arimori K,Okumura M,Hidaka M,Yamada M,Sakushima A

更新日期：2008-07-01 00:00:00

abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...

journal_title：Journal of natural medicines

authors： Ma NT,Zhou R,Chang RY,Hao YJ,Ma L,Jin SJ,Du J,Zheng J,Zhao CJ,Niu Y,Sun T,Li W,Koike K,Yu JQ,Li YX

更新日期：2015-10-01 00:00:00

abstract：:Although Radix Angelicae dahuricae (Angelica) has been traditionally used in patients with rheumatism arthralgia, its bioactive ingredients remain to be determined. In this study, the essential oil extract of Radix Angelicae dahuricae (EOAD) was assessed for its anti-inflammatory activities against xylene-induced acut...

journal_title：Journal of natural medicines

authors： Wang C,Sun J,Li H,Yang X,Liu H,Chen J

更新日期：2016-07-01 00:00:00

abstract：:Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced produ...

journal_title：Journal of natural medicines

authors： Inaba K,Murata K,Naruto S,Matsuda H

更新日期：2010-04-01 00:00:00

abstract：:In recent years, Spirulina has gained more and more attention from medical scientists as a nutraceutical and a source of potential pharmaceuticals. The present study was conducted to elucidate the immunomodulatory effect of Spirulina fusiformis (a cyanobacterium of the family Oscillatoriaceae) in vivo and in vitro. Th...

journal_title：Journal of natural medicines

authors： Rasool M,Sabina EP

更新日期：2009-04-01 00:00:00

abstract：:A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...

journal_title：Journal of natural medicines

authors： Sugimoto S,Yamano Y,Khalil HE,Otsuka H,Kamel MS,Matsunami K

更新日期：2017-07-01 00:00:00

abstract：:Chresta martii (Asteraceae) is a plant found in the Xingó region (semi-arid area) in Northeastearn Brazil, and is recognized by the local population as a traditional herb used to treat gastric diseases. This is the first report of the chemical composition, acute toxicity, and gastroprotective effect in mice of the hyd...

journal_title：Journal of natural medicines

authors： Silva AA,Bezerra MM,Chaves HV,Pereira KM,Aguiar JA,Pinto VP,Abbet C,Simões-Pires CA,Franco ES,Henriques AT,Hostettmann K,Maia MB

更新日期：2013-01-01 00:00:00

abstract：:A new aromatic derivative, 5-(3,4-dihydroxyphenyl)-3-methylcyclohex-2-enone (1), and three known compounds, peltigerine, solorinine, and phenyl butanoid, were isolated from the MeOH extract of the lichen Peltigera dolichorrhiza (Peltigeraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance a...

journal_title：Journal of natural medicines

authors： Yoshikawa K,Kunioka E,Kokudo N,Hashimoto T

更新日期：2010-07-01 00:00:00

abstract：:The purpose of the study was to evaluate the suppressive effect of TJ-68 on duodenal spasms during endoscopic retrograde cholangiopancreatography (ERCP). At the point when the duodenal papilla was confirmed after insertion of the endoscope during ERCP, 5.0 g TJ-68 (Tsumura Co., Tokyo, Japan) was dissolved in 50 ml of ...

journal_title：Journal of natural medicines

authors： Sakai Y,Tsuyuguchi T,Ishihara T,Kato K,Tsuboi M,Ooka Y,Katsuura K,Ohara T,Takayama S,Kimura M,Kasanuki J,Ai M,Yokosuka O

更新日期：2009-04-01 00:00:00

abstract：:The binding properties of recombinant antibody fragments, such as affinity and specificity, determine their usefulness for therapeutic and analytical applications. Anti-paclitaxel single-chain variable fragment clone 1C2 (anti-PT scFv1C2) was expressed using Escherichia coli cell and Bombyx mori larvae expression syst...

journal_title：Journal of natural medicines

authors： Yusakul G,Sakamoto S,Nuntawong P,Tanaka H,Morimoto S

更新日期：2018-01-01 00:00:00

abstract：:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...

journal_title：Journal of natural medicines

authors： Okamoto T,Akita N,Terasawa M,Hayashi T,Suzuki K

更新日期：2019-06-01 00:00:00

abstract：:This experiment's with aim was to study the pharmacokinetics of asperosaponin VI and its three metabolites (cauloside A, HN saponin F and hederagenin) via a sensitive high performance liquid chromatography connected with electrospray ionization triple quadrupole mass spectrum (HPLC-ESI-MS/MS). Chromatographic separati...

journal_title：Journal of natural medicines

authors： Liu EW,Wang JL,Han LF,Chang YX,Wang T,Huo Y,Wang L,Gao XM

更新日期：2014-07-01 00:00:00

abstract：:The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ...

journal_title：Journal of natural medicines

authors： Chen H,Olatunji OJ,Zhou Y

更新日期：2016-07-01 00:00:00

abstract：:The aim of the study was to investigate the in vivo effect of the seashell protein Haishengsu (HSS) on Ehrlich ascites tumor. Mice were inoculated with Ehrlich ascites tumor cells and randomly divided into three HSS groups and a control group. The survival times in the three HSS-treated groups was longer than in the c...

journal_title：Journal of natural medicines

authors： Liu JZ,Chen SG,Bin Z,Wang CB,Li GY,Wang LX

更新日期：2009-10-01 00:00:00

abstract：:Cancer cachexia is a complex and multifactorial syndrome that influences about 50-80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal m...

journal_title：Journal of natural medicines

authors： Ge Z,Liu D,Shang Y,Li Y,Chen SZ

更新日期：2020-09-01 00:00:00

abstract：:Cosmetic industries focus on developing materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic extract of the leaves of Callicarpa longissima inhibits melanin production in B16F10 mouse melanoma cells by s...

journal_title：Journal of natural medicines

authors： Yamahara M,Sugimura K,Kumagai A,Fuchino H,Kuroi A,Kagawa M,Itoh Y,Kawahara H,Nagaoka Y,Iida O,Kawahara N,Takemori H,Watanabe H

更新日期：2016-01-01 00:00:00

abstract：:The present study aimed at investigating the effect of carvacrol on hepatic mitochondrial enzyme activities and DNA damage in D: -galactosamine (D: -GalN)-induced hepatotoxicity in male albino Wistar rats. The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, ...

journal_title：Journal of natural medicines

authors： Aristatile B,Al-Numair KS,Al-Assaf AH,Pugalendi KV

更新日期：2011-07-01 00:00:00

abstract：:An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...

journal_title：Journal of natural medicines

authors： Hasuda T,Hitotsuyanagi Y,Takeya K

更新日期：2011-07-01 00:00:00

abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...

journal_title：Journal of natural medicines

authors： Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki T

更新日期：2011-07-01 00:00:00