Protective effects of aloperine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion.

abstract：:The binding properties of recombinant antibody fragments, such as affinity and specificity, determine their usefulness for therapeutic and analytical applications. Anti-paclitaxel single-chain variable fragment clone 1C2 (anti-PT scFv1C2) was expressed using Escherichia coli cell and Bombyx mori larvae expression syst...

journal_title：Journal of natural medicines

authors： Yusakul G,Sakamoto S,Nuntawong P,Tanaka H,Morimoto S

更新日期：2018-01-01 00:00:00

abstract：:Ephedra Herb is a crude drug defined as the terrestrial stem of Ephedra sinica, E. intermedia, or E. equisetina. It is often used to treat headaches, bronchial asthma, nasal inflammation, and the common cold. In this study, we isolated characteristic non-alkaloidal constituents from the extracts and identified them in...

journal_title：Journal of natural medicines

authors： Oshima N,Yamashita T,Uchiyama N,Hyuga S,Hyuga M,Yang J,Hakamatsuka T,Hanawa T,Goda Y

更新日期：2019-01-01 00:00:00

abstract：:Aconitum vilmorinianum Komarov is a local medicinal plant used in many well-known clinical preparations to treat rheumatism and pains in Yunnan Province, China. Phytochemical examination of the roots of A. vilmorinianum led to the isolation of three novel imine-type norditerpenoid alkaloids named vilmorrianines E-G (1...

journal_title：Journal of natural medicines

authors： Chen CL,Tan WH,Wang Y,Xue ZG,Wan CP,Yang ZY,Zhou ZH,Ma XX

更新日期：2015-10-01 00:00:00

abstract：:A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compo...

journal_title：Journal of natural medicines

authors： Amen YM,Zhu Q,Tran HB,Afifi MS,Halim AF,Ashour A,Mira A,Shimizu K

更新日期：2016-07-01 00:00:00

abstract：:Activity-guided isolation of the n-butanol fraction of Chamaerhodos erecta and water soluble fraction of C. altaica resulted in the isolation of 39 compounds, including new compounds identified as 4,5-dihydroxybenzaldehyde-3-O-β-D-glucopyranoside (1) from C. erecta and quercetin-3-O-β-D-glucuronopyranosyl-4'-O-β-D-glu...

journal_title：Journal of natural medicines

authors： Selenge E,Odontuya G,Murata T,Sasaki K,Kobayashi K,Batkhuu J,Yoshizaki F

更新日期：2013-10-01 00:00:00

abstract：:Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eigh...

journal_title：Journal of natural medicines

authors： Rahman AK,Chowdhury AK,Ali HA,Raihan SZ,Ali MS,Nahar L,Sarker SD

更新日期：2009-01-01 00:00:00

abstract：:A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...

journal_title：Journal of natural medicines

authors： Sugimoto S,Yamano Y,Khalil HE,Otsuka H,Kamel MS,Matsunami K

更新日期：2017-07-01 00:00:00

abstract：:A new diterpenoid was isolated from the leaves of Clerodendron trichotomumThunb. (Verbenaceae) along with one each of a known diterpenoid, phenylethanoid glycoside, and sterol and two known flavonoids. Their chemical structures were characterized on the basis of spectroscopic data and X-ray analysis. In addition, thei...

journal_title：Journal of natural medicines

authors： Ono M,Furusawa C,Matsumura K,Noguchi S,Yasuda S,Okawa M,Kinjo J,Eto M,Yamaguchi K,Yoshimitsu H,Nohara T

更新日期：2013-04-01 00:00:00

abstract：:A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolu...

journal_title：Journal of natural medicines

authors： Wu C,He L,Yi X,Qin J,Li Y,Zhang Y,Wang G

更新日期：2019-06-01 00:00:00

abstract：:Since prostate growth is governed by the androgen signaling pathway, blockade of the pathway is regarded as an appropriate strategy for the treatment of benign prostatic hyperplasia (BPH). Panax ginseng is known to have various pharmacological activities. Of several products of its root, red ginseng, having many bioac...

journal_title：Journal of natural medicines

authors： Bae JS,Park HS,Park JW,Li SH,Chun YS

更新日期：2012-07-01 00:00:00

abstract：:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...

journal_title：Journal of natural medicines

authors： Yamaguchi I,Matsuda H,Zhang H,Hamao M,Yamashita C,Kogami Y,Kon'I H,Murata M,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...

journal_title：Journal of natural medicines

authors： Takemoto H,Ito M,Shiraki T,Yagura T,Honda G

更新日期：2008-01-01 00:00:00

abstract：:From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...

journal_title：Journal of natural medicines

authors： Qu Y,Xu F,Nakamura S,Matsuda H,Pongpiriyadacha Y,Wu L,Yoshikawa M

更新日期：2009-01-01 00:00:00

abstract：:Acanthopanax senticosus HARMS (AS) is used as a Chinese herbal medicine and as a health supplement in Japan. However, little is known about the interaction between AS and other drugs. In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporte...

journal_title：Journal of natural medicines

authors： Takahashi T,Kaku T,Sato T,Watanabe K,Sato J

更新日期：2010-01-01 00:00:00

abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. H...

journal_title：Journal of natural medicines

authors： Cai WH,Matsunami K,Otsuka H,Shinzato T,Takeda Y

更新日期：2011-04-01 00:00:00

abstract：:(E)-methyl-4-hydroxy-3,5-dimethoxycinnamate, (E)-methyl-4-hydroxy-3-methoxycinnamate, (E)-methyl-4-hydroxycinnamate, (Z)-methyl-4-hydroxycinnamate, calycanthine, ursolic acid, 2-hydroxy-3-methylanthraquinone, 4-methoxybenzoic acid, 3,4,5-trimethoxybenzoic acid, methyl 4-hydroxybenzoate and allantoin were isolated from...

journal_title：Journal of natural medicines

authors： da Silva VC,de Carvalho MG,Alves AN

更新日期：2008-07-01 00:00:00

abstract：:Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (4-25) were obtained from the 70% ethanol-water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods. Among the known compounds, 14, 15, 17 and 23 were firstly obtained from ...

journal_title：Journal of natural medicines

authors： Zhang Y,Huang P,He W,Sakah KJ,Ruan J,Li Z,Wang T

更新日期：2019-01-01 00:00:00

abstract：:Five polyphenolic compounds were identified from the diethyl ether and ethyl acetate extracts of the herb of ragged robin, Lychnis flos-cuculi L. (Caryophyllaceae). The identified and isolated compounds were established as a caffeic acid, luteolin, apigenin, apigenin 8-C-beta-D-glucopyranoside (vitexin) and luteolin 8...

journal_title：Journal of natural medicines

authors： Tomczyk M

更新日期：2008-10-01 00:00:00

abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...

journal_title：Journal of natural medicines

authors： Shimada K,Nakamura Y,Kawase M,Komatsu K,Saito T,Takahashi K

更新日期：2014-04-01 00:00:00

abstract：:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...

journal_title：Journal of natural medicines

authors： Yano M,Nakashima S,Oda Y,Nakamura S,Matsuda H

更新日期：2020-01-01 00:00:00

abstract：:Five new coumarins, (+)-peujaponisin (1) and multivittans A-D (2-5), were isolated from the roots of Ligusticum multivittatum Franch., and their structures were established by spectral means. ...

journal_title：Journal of natural medicines

authors： Kondo T,Taniguchi M,Shibano M,Wang NH,Baba K

更新日期：2008-01-01 00:00:00

abstract：:A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenet...

journal_title：Journal of natural medicines

authors： Hara Y,Totsugi Y,Ichikawa H,Harada S,Fujii K,Ahmed F,Sadhu SK,Arai MA,Ishibashi M

更新日期：2021-01-01 00:00:00

abstract：:It is generally accepted that fungi have a number of dormant gene clusters for the synthesis of secondary metabolites, and the activation of these gene clusters can expand the diversity of secondary metabolites in culture. Recent studies have revealed that the mycolic acid-containing bacterium Tsukamurella pulmonis ac...

journal_title：Journal of natural medicines

authors： Jomori T,Hara Y,Sasaoka M,Harada K,Setiawan A,Hirata K,Kimishima A,Arai M

更新日期：2020-01-01 00:00:00

abstract：:Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the ...

journal_title：Journal of natural medicines

authors： Ham YM,Song HS,Kwon JE,Jeon H,Baek HJ,Kim CW,Yoon WJ,Choung ES,Kang SC

更新日期：2019-01-01 00:00:00

abstract：:The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring m...

journal_title：Journal of natural medicines

authors： Kasamatsu S,Hachiya A,Shimotoyodome Y,Kameyama A,Miyauchi Y,Higuchi K,Fujimori T,Ohuchi A,Shibuya Y,Kitahara T

更新日期：2014-07-01 00:00:00

abstract：:We screened water and methanol extracts of 28 Indonesian medicinal plants for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Nine water extracts, i.e., Alstonia scholaris leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Sy...

journal_title：Journal of natural medicines

authors： Saifudin A,Kadota S,Tezuka Y

更新日期：2013-04-01 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy (CIPN) manifests as mechanical allodynia and hyperalgesia, and is one of the main adverse effects of chemotherapeutic agents. Currently available therapeutic drugs are not sufficiently effective for the management of this adverse effect in the clinic. Therefore, the developme...

journal_title：Journal of natural medicines

authors： Yu H,Toume K,Kurokawa Y,Andoh T,Komatsu K

更新日期：2021-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...

journal_title：Journal of natural medicines

authors： Hisayoshi T,Shinomura M,Yokokawa K,Kuze I,Konishi A,Kawaji K,Kodama EN,Hata K,Takahashi S,Nirasawa S,Sakuda S,Yasukawa K

更新日期：2015-07-01 00:00:00

abstract：:In recent years, Spirulina has gained more and more attention from medical scientists as a nutraceutical and a source of potential pharmaceuticals. The present study was conducted to elucidate the immunomodulatory effect of Spirulina fusiformis (a cyanobacterium of the family Oscillatoriaceae) in vivo and in vitro. Th...

journal_title：Journal of natural medicines

authors： Rasool M,Sabina EP

更新日期：2009-04-01 00:00:00

abstract：:A methanolic extract of Argusia (or Messerschmidia or Tournefortia) argentea (Boraginaceae) significantly inhibited hemorrhage induced by crude venom of Trimeresurus flavoviridis. The extract was then separated according to antivenom activity by using silica gel column chromatography and HPLC equipped with an octadecy...

journal_title：Journal of natural medicines

authors： Aung HT,Nikai T,Niwa M,Takaya Y

更新日期：2010-10-01 00:00:00