当前位置： SCI文献检索 > Journal of Natural Medicines期刊下所有文献 > The inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit expression.

The inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit expression.

Abstract：

:The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring melanocytes via their Kit receptors. In order to identify effective skin-lightening materials, we screened botanical extracts to determine their abilities to diminish Kit expression in melanocytes. A Platycodon root extract was consequently found to have a remarkable inhibitory activity on Kit expression. When the extract was applied to three-dimensional human skin substitutes in vitro and to human skin in vivo after UVB irradiation, their pigmentation was significantly reduced, confirming the substantial contribution of the suppression of SCF/Kit signaling to preventing or inhibiting melanin synthesis. These data demonstrate that a Platycodon root extract is a promising material for a skin-lightening product to improve pigmentation-related diseases.

journal_name

J Nat Med

journal_title

Journal of natural medicines

authors

Kasamatsu S,Hachiya A,Shimotoyodome Y,Kameyama A,Miyauchi Y,Higuchi K,Fujimori T,Ohuchi A,Shibuya Y,Kitahara T

doi

10.1007/s11418-014-0836-x

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

643-6

issue

3

eissn

1340-3443

issn

1861-0293

journal_volume

68

pub_type

杂志文章

相关文献

Journal of Natural Medicines文献大全
  • A glycerol α-D-glucuronide and a megastigmane glycoside from the leaves of Guettarda speciosa L.

    abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. H...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-010-0484-8

    authors： Cai WH,Matsunami K,Otsuka H,Shinzato T,Takeda Y

    更新日期：2011-04-01 00:00:00

  • A new arylbenzofuran from the aerial parts of alfalfa.

    abstract：:A new arylbenzofuran, 4-hydroxy-2-(4'-hydroxy-2'-methoxyphenyl)-6-methoxybenzofu-ran-3-carbaldehyde (1), was isolated from the aerial parts of alfalfa (Medicago sativa L.), together with three known compounds. The structure of the new compound (1) was determined by spectroscopic methods. ...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-008-0297-1

    authors： Wang S,Zhang G,Guan J,Zhu L,Chen L,Pan C,Li P,Li L

    更新日期：2009-04-01 00:00:00

  • The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock.

    abstract：:Nardostachys jatamansi (NJ) has been used in the treatment of inflammatory diseases. However, it is not clear how NJ produces anti-inflammatory effects. In the present study, using an experimental model of lipopolysaccharide (LPS)-induced endotoxin shock, the protective effects and mechanisms of action of NJ were inve...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-010-0458-x

    authors： Bae GS,Seo SW,Kim MS,Park KC,Koo BS,Jung WS,Cho GH,Oh HC,Yun SW,Kim JJ,Kim SG,Hwang SY,Song HJ,Park SJ

    更新日期：2011-01-01 00:00:00

  • Two new compounds from the roots of Ilex pubescens and their cytotoxic activity.

    abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-016-0996-y

    authors： Xiong H,Zhao F,Bi J,Zhang Y,Zhao G,Chen X,Li Y,Yan R,Zhao Q,Qiao H,Zhang G

    更新日期：2016-07-01 00:00:00

  • Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells.

    abstract：:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-019-01289-5

    authors： Okamoto T,Akita N,Terasawa M,Hayashi T,Suzuki K

    更新日期：2019-06-01 00:00:00

  • Establishment of a methodology for identifying Paeoniae Radix based on metallomic analysis.

    abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-013-0795-7

    authors： Shimada K,Nakamura Y,Kawase M,Komatsu K,Saito T,Takahashi K

    更新日期：2014-04-01 00:00:00

  • Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.

    abstract：:Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and behavioral analysis,...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-015-0929-1

    authors： Iwaoka E,Wang S,Matsuyoshi N,Kogure Y,Aoki S,Yamamoto S,Noguchi K,Dai Y

    更新日期：2016-01-01 00:00:00

  • Non-alkaloidal composition of Ephedra Herb is influenced by differences in habitats.

    abstract：:Ephedra Herb is a crude drug defined as the terrestrial stem of Ephedra sinica, E. intermedia, or E. equisetina. It is often used to treat headaches, bronchial asthma, nasal inflammation, and the common cold. In this study, we isolated characteristic non-alkaloidal constituents from the extracts and identified them in...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-018-1265-z

    authors： Oshima N,Yamashita T,Uchiyama N,Hyuga S,Hyuga M,Yang J,Hakamatsuka T,Hanawa T,Goda Y

    更新日期：2019-01-01 00:00:00

  • Furostanol glycosides from the rhizomes of Helleborus orientalis.

    abstract：:Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-010-0432-7

    authors： Mimaki Y,Matsuo Y,Watanabe K,Sakagami H

    更新日期：2010-10-01 00:00:00

  • Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.

    abstract：:Cosmetic industries focus on developing materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic extract of the leaves of Callicarpa longissima inhibits melanin production in B16F10 mouse melanoma cells by s...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-015-0933-5

    authors： Yamahara M,Sugimura K,Kumagai A,Fuchino H,Kuroi A,Kagawa M,Itoh Y,Kawahara H,Nagaoka Y,Iida O,Kawahara N,Takemori H,Watanabe H

    更新日期：2016-01-01 00:00:00

  • Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.

    abstract：:The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-019-01357-w

    authors： Tang R,Kimishima A,Ishida R,Setiawan A,Arai M

    更新日期：2020-01-01 00:00:00

  • Sedative effects of vapor inhalation of agarwood oil and spikenard extract and identification of their active components.

    abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-007-0177-0

    authors： Takemoto H,Ito M,Shiraki T,Yagura T,Honda G

    更新日期：2008-01-01 00:00:00

  • Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells.

    abstract：:Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a basta...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-006-0045-3

    authors： Aoki S,Cho SH,Hiramatsu A,Kotoku N,Kobayashi M

    更新日期：2006-07-01 00:00:00

  • New depsidone and dichromone from the stems of Garcinia paucinervis with antiproliferative activity.

    abstract：:A new depsidone, paucinervin Q (1), a new dichromone, paucinervin R (2), and a known compound, paucinervin B (3), were isolated from the stems of Garcinia paucinervis by various chromatographic methods. Their structures were determined by analysis of spectroscopic data. The isolates were evaluated for their antiprolif...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-018-1247-1

    authors： Jia C,Xue J,Li X,Li D,Li Z,Hua H

    更新日期：2019-01-01 00:00:00

  • Composition of the endophytic filamentous fungi isolated from the tea plant Camellia sinensis.

    abstract：:It has been found by ribosomal DNA analysis that the endophytic filamentous fungi isolated from the tea plant Camellia sinensis (Theaceae) are composed of six groups; one Fusarium sp., one Penicillium sp., two Schizophyllum sp., and two Diaporthe sp.. ...

    journal_title：Journal of natural medicines

    pub_type： 社论

    doi：10.1007/s11418-006-0038-2

    authors： Agusta A,Ohashi K,Shibuya H

    更新日期：2006-07-01 00:00:00

  • Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives.

    abstract：:Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous studies with β-PGG revealed a wide variety of biological activities, such as anti-microbial and an...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1007/s11418-014-0823-2

    authors： Cao Y,Himmeldirk KB,Qian Y,Ren Y,Malki A,Chen X

    更新日期：2014-07-01 00:00:00

  • Effect of altitude on picroside content in core collections of Picrorhiza kurrooa from the north western Himalayas.

    abstract：:Picrorhiza kurrooa Royle ex Benth (Scrophulariaceae), commonly known as Kutki, is a major ingredient of many ayurvedic preparations prescribed in the treatment of various diseases. Picrosides I and II are the active agents responsible for the medicinal effects of Kutki, and the variation in content of these compounds ...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-010-0491-9

    authors： Katoch M,Fazli IS,Suri KA,Ahuja A,Qazi GN

    更新日期：2011-07-01 00:00:00

  • Tetrandrine triggers apoptosis and cell cycle arrest in human renal cell carcinoma cells.

    abstract：:Tetrandrine is a cytotoxic compound capable of exerting remarkable antitumor activity against many cancer cells in vitro and in vivo. However, little is known about its effect on human renal cell carcinoma (RCC). In the present study, using RCC 786-O, 769-P and ACHN cell lines as the model system, we demonstrated the ...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-013-0765-0

    authors： Chen T,Ji B,Chen Y

    更新日期：2014-01-01 00:00:00

  • Two new diterpenoids from Leonotis leonurus R. Br.

    abstract：:Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the ...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-014-0868-2

    authors： Narukawa Y,Komori M,Niimura A,Noguchi H,Kiuchi F

    更新日期：2015-01-01 00:00:00

  • Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders.

    abstract：:Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-011-0605-z

    authors： Khan M,Khan AU,Najeeb-ur-Rehman,Gilani AH

    更新日期：2012-04-01 00:00:00

  • Rigenolides D-H, norsecoiridoid and secoiridoids from Gentiana rigescens Franch.

    abstract：:Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dieno...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-018-1181-2

    authors： Suyama Y,Tanaka N,Kawazoe K,Murakami K,Li SL,Sun HD,Kashiwada Y

    更新日期：2018-03-01 00:00:00

  • Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model.

    abstract：:In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF)...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-018-1175-0

    authors： Yamauchi K,Mitsunaga T

    更新日期：2018-03-01 00:00:00

  • Difference of ITS sequences of Akebia plants growing in various parts of Japan.

    abstract：:The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...

    journal_title：Journal of natural medicines

    pub_type： 信件

    doi：10.1007/s11418-009-0318-8

    authors： Kitaoka F,Kakiuchi N,Long C,Itoga M,Yoshimatsu H,Mitsue A,Atsumi T,Mouri C,Mikage M

    更新日期：2009-07-01 00:00:00

  • Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models.

    abstract：:This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory a...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-007-0224-x

    authors： Zakaria ZA,Ghani ZD,Nor RN,Gopalan HK,Sulaiman MR,Jais AM,Somchit MN,Kader AA,Ripin J

    更新日期：2008-04-01 00:00:00

  • What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?

    abstract：:Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is commonly used as a tocolytic agent. In this study, the components of AMR that are responsible for its expect...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-015-0934-4

    authors： Wang X,Li L,Ran X,Dou D,Li B,Yang B,Li W,Koike K,Kuang H

    更新日期：2016-01-01 00:00:00

  • Magnolol inhibits myotube atrophy induced by cancer cachexia through myostatin signaling pathway in vitro.

    abstract：:Cancer cachexia is a complex and multifactorial syndrome that influences about 50-80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal m...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-020-01428-3

    authors： Ge Z,Liu D,Shang Y,Li Y,Chen SZ

    更新日期：2020-09-01 00:00:00

  • Resveratrol oligomer structure in Dipterocarpaceaeous plants.

    abstract：:Oligostilbenoids are a group of natural products derived from the oxidative coupling of C6-C2-C6 units found in some plant families. A structurally diverse chemical pool is produced after the successive regioselective and stereoselective oligomerization of resveratrol. This review describes the current status and know...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1007/s11418-020-01412-x

    authors： Ito T

    更新日期：2020-09-01 00:00:00

  • Antithrombosis activity of protocatechuic and shikimic acids from functional plant Pinus densiflora Sieb. et Zucc needles.

    abstract：:Pine needle extract (PE) and fermented pine needle extract (FPE) have been reported to show various biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, gastrointestinal motility control, and fibrinolytic effect. The aims of our research were to isolate fi...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-015-0956-y

    authors： Park J,Lee B,Choi H,Kim W,Kim HJ,Cheong H

    更新日期：2016-07-01 00:00:00

  • Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan.

    abstract：:This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...

    journal_title：Journal of natural medicines

    pub_type： 信件

    doi：10.1007/s11418-012-0630-6

    authors： Ebrahim AM,Eltayeb MH,Khalid H,Mohamed H,Abdalla W,Grill P,Michalke B

    更新日期：2012-10-01 00:00:00

  • Chemical constituents from leaves of Palicourea coriacea (Rubiaceae).

    abstract：:(E)-methyl-4-hydroxy-3,5-dimethoxycinnamate, (E)-methyl-4-hydroxy-3-methoxycinnamate, (E)-methyl-4-hydroxycinnamate, (Z)-methyl-4-hydroxycinnamate, calycanthine, ursolic acid, 2-hydroxy-3-methylanthraquinone, 4-methoxybenzoic acid, 3,4,5-trimethoxybenzoic acid, methyl 4-hydroxybenzoate and allantoin were isolated from...

    journal_title：Journal of natural medicines

    pub_type： 杂志文章

    doi：10.1007/s11418-008-0227-2

    authors： da Silva VC,de Carvalho MG,Alves AN

    更新日期：2008-07-01 00:00:00