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Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.

Abstract：

:A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compounds were evaluated against human colorectal carcinoma (HCT-116, Caco-2), human liver carcinoma (HepG2), and human cervical carcinoma (HeLa) cell lines using WST-1 reagent. Selectivity was evaluated using normal human fibroblast cells (TIG-1 and HF19). Among the compounds, lucidumol C showed potent selective cytotoxicity against HCT-116 cells with an IC50 value of 7.86 ± 4.56 µM and selectivity index (SI) >10 with remarkable cytotoxic activities against Caco-2, HepG2 and HeLa cell lines.

journal_name

J Nat Med

journal_title

Journal of natural medicines

authors

Amen YM,Zhu Q,Tran HB,Afifi MS,Halim AF,Ashour A,Mira A,Shimizu K

doi

10.1007/s11418-016-0976-2

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

661-6

issue

3

eissn

1340-3443

issn

1861-0293

pii

10.1007/s11418-016-0976-2

journal_volume

70

pub_type

杂志文章

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