Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry.

abstract：:This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...

journal_title：Journal of natural medicines

authors： Ebrahim AM,Eltayeb MH,Khalid H,Mohamed H,Abdalla W,Grill P,Michalke B

更新日期：2012-10-01 00:00:00

abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of Euphorbia hirta, collected in the Okinawa islands, three new megastigmane glucoside gallates, named hirtionosides A-C, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside were isolated along with 15 known compounds. The structures of the new compounds...

journal_title：Journal of natural medicines

authors： Nomoto Y,Sugimoto S,Matsunami K,Otsuka H

更新日期：2013-04-01 00:00:00

abstract：:Near-infrared (NIR) spectroscopy combined with chemometrics has been utilized in predictions of natural medicine content without destroying samples. Suppositories (oren powdered extract content 0, 0.5, 1.0, 2.5, 10, 12.5, and 15%) were produced by mixing oren powdered extract with macrogol mixture consisting of 1 part...

journal_title：Journal of natural medicines

authors： Teraoka R,Abe H,Sugama T,Ito K,Aburada M,Otsuka M

更新日期：2012-04-01 00:00:00

abstract：:The aim of the study was to investigate the in vivo effect of the seashell protein Haishengsu (HSS) on Ehrlich ascites tumor. Mice were inoculated with Ehrlich ascites tumor cells and randomly divided into three HSS groups and a control group. The survival times in the three HSS-treated groups was longer than in the c...

journal_title：Journal of natural medicines

authors： Liu JZ,Chen SG,Bin Z,Wang CB,Li GY,Wang LX

更新日期：2009-10-01 00:00:00

abstract：:The known seco-cucurbitane triterpene, (24E)-3,4-seco-cucurbita-4,24-diene-3,26,29-trioic acid (1), has been isolated as a potent protein tyrosine phosphatase (PTP) 1B inhibitor together with a new analogue, (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid (2), from the fruiting bodies of Russula lepida....

journal_title：Journal of natural medicines

authors： Maarisit W,Yamazaki H,Kanno SI,Tomizawa A,Lee JS,Namikoshi M

更新日期：2017-01-01 00:00:00

abstract：:A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenet...

journal_title：Journal of natural medicines

authors： Hara Y,Totsugi Y,Ichikawa H,Harada S,Fujii K,Ahmed F,Sadhu SK,Arai MA,Ishibashi M

更新日期：2021-01-01 00:00:00

abstract：:The hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves was studied in Triton WR-1339- and high fat diet-induced hyperlipidemic rats. In Triton WR-1339-induced hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) exerted a significant (P < 0.01) lipid-lowering effect compared to ethyl acetate an...

journal_title：Journal of natural medicines

authors： Sunil C,Ignacimuthu S,Kumarappan C

更新日期：2012-01-01 00:00:00

abstract：:Alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction of the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennat and Q. coccinea, gave three new glycosidic acids (maltifidinic acids C, D, and E) along with three known glycosidic acids (quamocli...

journal_title：Journal of natural medicines

authors： Ono M,Kishida M,Ikegami Y,Takaki Y,Okawa M,Kinjo J,Yoshimitsu H,Nohara T,Miyahara K

更新日期：2011-01-01 00:00:00

abstract：:Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1-2) with six known congeners (3-8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit throu...

journal_title：Journal of natural medicines

authors： Zhao GY,Deng BW,Zhang CY,Cui YD,Bi JY,Zhang GG

更新日期：2018-01-01 00:00:00

abstract：:The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring m...

journal_title：Journal of natural medicines

authors： Kasamatsu S,Hachiya A,Shimotoyodome Y,Kameyama A,Miyauchi Y,Higuchi K,Fujimori T,Ohuchi A,Shibuya Y,Kitahara T

更新日期：2014-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...

journal_title：Journal of natural medicines

authors： Hisayoshi T,Shinomura M,Yokokawa K,Kuze I,Konishi A,Kawaji K,Kodama EN,Hata K,Takahashi S,Nirasawa S,Sakuda S,Yasukawa K

更新日期：2015-07-01 00:00:00

abstract：:The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...

journal_title：Journal of natural medicines

authors： Kitaoka F,Kakiuchi N,Long C,Itoga M,Yoshimatsu H,Mitsue A,Atsumi T,Mouri C,Mikage M

更新日期：2009-07-01 00:00:00

abstract：:The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...

journal_title：Journal of natural medicines

authors： Tang R,Kimishima A,Ishida R,Setiawan A,Arai M

更新日期：2020-01-01 00:00:00

abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...

journal_title：Journal of natural medicines

authors： Salla M,Fakhoury I,Saliba N,Darwiche N,Gali-Muhtasib H

更新日期：2013-07-01 00:00:00

abstract：:Five new coumarins, (+)-peujaponisin (1) and multivittans A-D (2-5), were isolated from the roots of Ligusticum multivittatum Franch., and their structures were established by spectral means. ...

journal_title：Journal of natural medicines

authors： Kondo T,Taniguchi M,Shibano M,Wang NH,Baba K

更新日期：2008-01-01 00:00:00

abstract：:Fufang Xueshuantong Capsule (FXST) can reduce urinary albumin and whole blood viscosity in early diabetic nephropathy (DN) patients. This research aimed to investigate the effect of FXST on kidney function in DN rats and to identify the underlying molecular mechanisms. We performed Illumina RatRef-12 Expression BeadCh...

journal_title：Journal of natural medicines

authors： Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

更新日期：2013-01-01 00:00:00

abstract：:This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory a...

journal_title：Journal of natural medicines

authors： Zakaria ZA,Ghani ZD,Nor RN,Gopalan HK,Sulaiman MR,Jais AM,Somchit MN,Kader AA,Ripin J

更新日期：2008-04-01 00:00:00

abstract：:Chresta martii (Asteraceae) is a plant found in the Xingó region (semi-arid area) in Northeastearn Brazil, and is recognized by the local population as a traditional herb used to treat gastric diseases. This is the first report of the chemical composition, acute toxicity, and gastroprotective effect in mice of the hyd...

journal_title：Journal of natural medicines

authors： Silva AA,Bezerra MM,Chaves HV,Pereira KM,Aguiar JA,Pinto VP,Abbet C,Simões-Pires CA,Franco ES,Henriques AT,Hostettmann K,Maia MB

更新日期：2013-01-01 00:00:00

abstract：:The hydroalcoholic extract of fruits of Ziziphus jujuba (ZJ) was investigated for its anti-inflammatory effect using acute and chronic models of inflammation in rat. Wistar albino rats of either sex were employed in the present study (n = 6). Acute inflammation was induced by subplantar administration of carrageenan (...

journal_title：Journal of natural medicines

authors： Goyal R,Sharma PL,Singh M

更新日期：2011-07-01 00:00:00

abstract：:Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous studies with β-PGG revealed a wide variety of biological activities, such as anti-microbial and an...

journal_title：Journal of natural medicines

authors： Cao Y,Himmeldirk KB,Qian Y,Ren Y,Malki A,Chen X

更新日期：2014-07-01 00:00:00

abstract：:Acanthopanax senticosus HARMS (AS) is used as a Chinese herbal medicine and as a health supplement in Japan. However, little is known about the interaction between AS and other drugs. In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporte...

journal_title：Journal of natural medicines

authors： Takahashi T,Kaku T,Sato T,Watanabe K,Sato J

更新日期：2010-01-01 00:00:00

abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...

journal_title：Journal of natural medicines

authors： Ma NT,Zhou R,Chang RY,Hao YJ,Ma L,Jin SJ,Du J,Zheng J,Zhao CJ,Niu Y,Sun T,Li W,Koike K,Yu JQ,Li YX

更新日期：2015-10-01 00:00:00

abstract：:Bioassay-guided fractionation led to the isolation of six new flavonol glycosides, floramanosides A (1), B (2), C (3), D (4), E (5), and F (6), from the flowers of Abelmouschus manihot. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D- and 2D-NMR). Activity screening res...

journal_title：Journal of natural medicines

authors： Zhang Y,He W,Li C,Chen Q,Han L,Liu E,Wang T

更新日期：2013-01-01 00:00:00

abstract：:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...

journal_title：Journal of natural medicines

authors： Yano M,Nakashima S,Oda Y,Nakamura S,Matsuda H

更新日期：2020-01-01 00:00:00

abstract：:Four hydrolyzable tannins [oenothein B (1), eugeniflorin D(2) (2), and tellimagrandins I (3) and II (4)], two related polyphenolic compounds [gallic acid (5) and quinic acid 3,5-di-O-gallate (6)], and four myricetin glycosides [myricetins 3-O-beta-D-xyloside (7), 3-O-beta-D-galactoside (8), 3-O-beta-D-galactoside 6''-...

journal_title：Journal of natural medicines

authors： Yoshimura M,Amakura Y,Tokuhara M,Yoshida T

更新日期：2008-07-01 00:00:00

abstract：:Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...

journal_title：Journal of natural medicines

authors： Prema,Wong CP,Nugroho AE,Awouafack MD,Win YY,Win NN,Ngwe H,Morita H,Morita H

更新日期：2019-06-01 00:00:00

abstract：:Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...

journal_title：Journal of natural medicines

authors： Mimaki Y,Matsuo Y,Watanabe K,Sakagami H

更新日期：2010-10-01 00:00:00

abstract：:Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic...

journal_title：Journal of natural medicines

authors： Kaur J,Sidhu S,Chopra K,Khan MU

更新日期：2016-07-01 00:00:00

abstract：:Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of the adipose tissue that leads to metabolic disorders, such as insulin resistance and type 2 diabetes mellitus. The regulation of immune cell infiltration into adipose tissue has prophylactic and t...

journal_title：Journal of natural medicines

authors： Tsuhako R,Yoshida H,Sugita C,Kurokawa M

更新日期：2020-01-01 00:00:00

abstract：:Activity-guided isolation of the n-butanol fraction of Chamaerhodos erecta and water soluble fraction of C. altaica resulted in the isolation of 39 compounds, including new compounds identified as 4,5-dihydroxybenzaldehyde-3-O-β-D-glucopyranoside (1) from C. erecta and quercetin-3-O-β-D-glucuronopyranosyl-4'-O-β-D-glu...

journal_title：Journal of natural medicines

authors： Selenge E,Odontuya G,Murata T,Sasaki K,Kobayashi K,Batkhuu J,Yoshizaki F

更新日期：2013-10-01 00:00:00