Abstract:
:Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A-M (8-20), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (2, IC50 = 11.2, 14.3, and 6.9 μM, respectively) showed relatively strong activities. The mechanism of action of 2 against HSC-2 was found to involve apoptotic cell death.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Ninomiya K,Motai C,Nishida E,Kitagawa N,Yoshihara K,Hayakawa T,Muraoka O,Li X,Nakamura S,Yoshikawa M,Matsuda H,Morikawa Tdoi
10.1007/s11418-016-0998-9subject
Has Abstractpub_date
2016-07-01 00:00:00pages
435-51issue
3eissn
1340-3443issn
1861-0293pii
10.1007/s11418-016-0998-9journal_volume
70pub_type
杂志文章abstract::An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Journal of natural medicines
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1190-1
更新日期:2018-06-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-008-0251-2
更新日期:2008-07-01 00:00:00