Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. acuta.

abstract：:From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...

journal_title：Journal of natural medicines

authors： Qu Y,Xu F,Nakamura S,Matsuda H,Pongpiriyadacha Y,Wu L,Yoshikawa M

更新日期：2009-01-01 00:00:00

abstract：:Autophagy is a catabolic process for degradation of intracellular components and plays an important role in the development and growth of cancer. Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the proliferation of HepG2 hepatocellular carcinoma cells and inhi...

journal_title：Journal of natural medicines

authors： Okubo S,Ohta T,Fujita H,Shoyama Y,Uto T

更新日期：2021-01-01 00:00:00

abstract：:A new aromatic derivative, 5-(3,4-dihydroxyphenyl)-3-methylcyclohex-2-enone (1), and three known compounds, peltigerine, solorinine, and phenyl butanoid, were isolated from the MeOH extract of the lichen Peltigera dolichorrhiza (Peltigeraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance a...

journal_title：Journal of natural medicines

authors： Yoshikawa K,Kunioka E,Kokudo N,Hashimoto T

更新日期：2010-07-01 00:00:00

abstract：:We screened water and methanol extracts of 28 Indonesian medicinal plants for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Nine water extracts, i.e., Alstonia scholaris leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Sy...

journal_title：Journal of natural medicines

authors： Saifudin A,Kadota S,Tezuka Y

更新日期：2013-04-01 00:00:00

abstract：:(E)-methyl-4-hydroxy-3,5-dimethoxycinnamate, (E)-methyl-4-hydroxy-3-methoxycinnamate, (E)-methyl-4-hydroxycinnamate, (Z)-methyl-4-hydroxycinnamate, calycanthine, ursolic acid, 2-hydroxy-3-methylanthraquinone, 4-methoxybenzoic acid, 3,4,5-trimethoxybenzoic acid, methyl 4-hydroxybenzoate and allantoin were isolated from...

journal_title：Journal of natural medicines

authors： da Silva VC,de Carvalho MG,Alves AN

更新日期：2008-07-01 00:00:00

abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...

journal_title：Journal of natural medicines

authors： Ma NT,Zhou R,Chang RY,Hao YJ,Ma L,Jin SJ,Du J,Zheng J,Zhao CJ,Niu Y,Sun T,Li W,Koike K,Yu JQ,Li YX

更新日期：2015-10-01 00:00:00

abstract：:The effects on guinea-pig heart muscle of extracts of Apocynum venetum L. leaf, root, stem, old stem and Venetron--a polyphenol-rich extract of leaves--were studied by recording the mechanical activity and heart rate of isolated right atria. Cymarin--a cardiac glycoside--was also determined in A. venetum extracts by L...

journal_title：Journal of natural medicines

authors： Irie K,Sato T,Tanaka I,Nakajima J,Kawaguchi M,Himi T

更新日期：2009-04-01 00:00:00

abstract：:A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolu...

journal_title：Journal of natural medicines

authors： Wu C,He L,Yi X,Qin J,Li Y,Zhang Y,Wang G

更新日期：2019-06-01 00:00:00

abstract：:This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...

journal_title：Journal of natural medicines

authors： Ebrahim AM,Eltayeb MH,Khalid H,Mohamed H,Abdalla W,Grill P,Michalke B

更新日期：2012-10-01 00:00:00

abstract：:Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and behavioral analysis,...

journal_title：Journal of natural medicines

authors： Iwaoka E,Wang S,Matsuyoshi N,Kogure Y,Aoki S,Yamamoto S,Noguchi K,Dai Y

更新日期：2016-01-01 00:00:00

abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...

journal_title：Journal of natural medicines

authors： Xiong H,Zhao F,Bi J,Zhang Y,Zhao G,Chen X,Li Y,Yan R,Zhao Q,Qiao H,Zhang G

更新日期：2016-07-01 00:00:00

abstract：:Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring c...

journal_title：Journal of natural medicines

authors： Makihara H,Shimada T,Machida E,Oota M,Nagamine R,Tsubata M,Kinoshita K,Takahashi K,Aburada M

更新日期：2012-07-01 00:00:00

abstract：:Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5 beta-tirucall-9(11),25-dien-3-one (1), squalene and a mixture of the phytosterols stigmasterol and beta-sitosterol. Micropl...

journal_title：Journal of natural medicines

authors： Tan MA,Takayama H,Aimi N,Kitajima M,Franzblau SG,Nonato MG

更新日期：2008-04-01 00:00:00

abstract：:In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral...

journal_title：Journal of natural medicines

authors： Sawamoto A,Okuyama S,Amakura Y,Yamada R,Yoshimura M,Nakajima M,Furukawa Y

更新日期：2018-01-01 00:00:00

abstract：:A novel, efficient, and accurate fingerprinting method using high performance liquid chromatography-photodiode array detection has been developed and optimized for the investigation and demonstration of the variance in chemical properties among Siraitia grosvenorii fruits from different origins. The effects of growth ...

journal_title：Journal of natural medicines

authors： Lu F,Li D,Fu C,Liu J,Huang Y,Chen Y,Wen Y,Nohara T

更新日期：2012-01-01 00:00:00

abstract：:Four hydrolyzable tannins [oenothein B (1), eugeniflorin D(2) (2), and tellimagrandins I (3) and II (4)], two related polyphenolic compounds [gallic acid (5) and quinic acid 3,5-di-O-gallate (6)], and four myricetin glycosides [myricetins 3-O-beta-D-xyloside (7), 3-O-beta-D-galactoside (8), 3-O-beta-D-galactoside 6''-...

journal_title：Journal of natural medicines

authors： Yoshimura M,Amakura Y,Tokuhara M,Yoshida T

更新日期：2008-07-01 00:00:00

abstract：:Isoorientin (ISO), a natural flavonoid compound, has been identified in several plants and its biological activity is determined and the study on lowering uric acid has not been reported. In view of the current status of treatment of hyperuricemia, we evaluated the hypouricemic effects of ISO in vivo and in vitro, and...

journal_title：Journal of natural medicines

authors： An MF,Wang MY,Shen C,Sun ZR,Zhao YL,Wang XJ,Sheng J

更新日期：2021-01-01 00:00:00

abstract：:An acyclic diterpene (plaunotol; 1) and two furanoditerpenes (plaunolide, 2 and plaunol E, 3), were isolated from Croton stellatopilosus leaves, and assessed for their inhibitory activity on nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 cells. Plaunotol, plaunolide and plaunol E exhibited i...

journal_title：Journal of natural medicines

authors： Premprasert C,Tewtrakul S,Plubrukarn A,Wungsintaweekul J

更新日期：2013-01-01 00:00:00

abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...

journal_title：Journal of natural medicines

authors： Shimada K,Nakamura Y,Kawase M,Komatsu K,Saito T,Takahashi K

更新日期：2014-04-01 00:00:00

abstract：:The article Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, written by Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma and Takashi Hakamatsuka, was originally published Online First with...

journal_title：Journal of natural medicines

authors： Nose M,Tada M,Kojima R,Nagata K,Hisaka S,Masada S,Homma M,Hakamatsuka T

更新日期：2018-03-01 00:00:00

abstract：:Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eigh...

journal_title：Journal of natural medicines

authors： Rahman AK,Chowdhury AK,Ali HA,Raihan SZ,Ali MS,Nahar L,Sarker SD

更新日期：2009-01-01 00:00:00

abstract：:Four new Amaryllidaceae alkaloids (1-4) possessing a homolycorine-type or a crinine-type skeleton have been isolated from the aerial part of Zephyranthes candida, and their structures were elucidated on the basis of spectroscopic data. The stereochemistry was elucidated by combination of NOESY correlations and CD anal...

journal_title：Journal of natural medicines

authors： Shitara N,Hirasawa Y,Hasumi S,Sasaki T,Matsumoto M,Wong CP,Kaneda T,Asakawa Y,Morita H

更新日期：2014-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...

journal_title：Journal of natural medicines

authors： Hisayoshi T,Shinomura M,Yokokawa K,Kuze I,Konishi A,Kawaji K,Kodama EN,Hata K,Takahashi S,Nirasawa S,Sakuda S,Yasukawa K

更新日期：2015-07-01 00:00:00

abstract：:Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with...

journal_title：Journal of natural medicines

authors： Jiang W,Shan TZ,Xu JJ,Chen WJ,Miao L,Lv MY,Tao L,Liu YQ

更新日期：2019-09-01 00:00:00

abstract：:This experiment's with aim was to study the pharmacokinetics of asperosaponin VI and its three metabolites (cauloside A, HN saponin F and hederagenin) via a sensitive high performance liquid chromatography connected with electrospray ionization triple quadrupole mass spectrum (HPLC-ESI-MS/MS). Chromatographic separati...

journal_title：Journal of natural medicines

authors： Liu EW,Wang JL,Han LF,Chang YX,Wang T,Huo Y,Wang L,Gao XM

更新日期：2014-07-01 00:00:00

abstract：:Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect ...

journal_title：Journal of natural medicines

authors： Morihara N,Hino A

更新日期：2017-01-01 00:00:00

abstract：:Alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction of the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennat and Q. coccinea, gave three new glycosidic acids (maltifidinic acids C, D, and E) along with three known glycosidic acids (quamocli...

journal_title：Journal of natural medicines

authors： Ono M,Kishida M,Ikegami Y,Takaki Y,Okawa M,Kinjo J,Yoshimitsu H,Nohara T,Miyahara K

更新日期：2011-01-01 00:00:00

abstract：:Chresta martii (Asteraceae) is a plant found in the Xingó region (semi-arid area) in Northeastearn Brazil, and is recognized by the local population as a traditional herb used to treat gastric diseases. This is the first report of the chemical composition, acute toxicity, and gastroprotective effect in mice of the hyd...

journal_title：Journal of natural medicines

authors： Silva AA,Bezerra MM,Chaves HV,Pereira KM,Aguiar JA,Pinto VP,Abbet C,Simões-Pires CA,Franco ES,Henriques AT,Hostettmann K,Maia MB

更新日期：2013-01-01 00:00:00

abstract：:Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced produ...

journal_title：Journal of natural medicines

authors： Inaba K,Murata K,Naruto S,Matsuda H

更新日期：2010-04-01 00:00:00

abstract：:The present study aimed at investigating the effect of carvacrol on hepatic mitochondrial enzyme activities and DNA damage in D: -galactosamine (D: -GalN)-induced hepatotoxicity in male albino Wistar rats. The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, ...

journal_title：Journal of natural medicines

authors： Aristatile B,Al-Numair KS,Al-Assaf AH,Pugalendi KV

更新日期：2011-07-01 00:00:00