Abstract：
:In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral abnormalities. Since sansoninto (SAT) extract exerted stronger effects than the other candidates tested, we investigated whether its oral administration ameliorates the pathologies of some mouse models of behavioral impairments. The results obtained suggested that SAT extract exerted anti-depression-like effects in the forced swim test, which may be mediated by the up-regulated expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. They may also be mediated by the enhanced phosphorylation of the cAMP response element-binding protein (CREB) via the mitogen-activated protein kinase (MAPK) cascade and Ca2+/calmodulin-dependent protein kinase II (CaMK II) cascade, a downstream signaling cascade of the N-methyl-D-aspartate (NMDA) receptor. These results indicate that the extract of SAT has potential as a new remedial medicine in the treatment of depression-like behavior.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Sawamoto A,Okuyama S,Amakura Y,Yamada R,Yoshimura M,Nakajima M,Furukawa Ydoi
10.1007/s11418-017-1119-0subject
Has Abstractpub_date
2018-01-01 00:00:00pages
118-126issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-017-1119-0journal_volume
72pub_type
杂志文章abstract：:The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharm...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1190-1
更新日期：2018-06-01 00:00:00
abstract：:From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0282-8
更新日期：2009-01-01 00:00:00
abstract：:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01368-7
更新日期：2020-01-01 00:00:00
abstract：:A new diterpenoid was isolated from the leaves of Clerodendron trichotomumThunb. (Verbenaceae) along with one each of a known diterpenoid, phenylethanoid glycoside, and sterol and two known flavonoids. Their chemical structures were characterized on the basis of spectroscopic data and X-ray analysis. In addition, thei...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0690-7
更新日期：2013-04-01 00:00:00
abstract：:Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihyd...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1125-2
更新日期：2018-01-01 00:00:00
abstract：:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01289-5
更新日期：2019-06-01 00:00:00
abstract：:The binding properties of recombinant antibody fragments, such as affinity and specificity, determine their usefulness for therapeutic and analytical applications. Anti-paclitaxel single-chain variable fragment clone 1C2 (anti-PT scFv1C2) was expressed using Escherichia coli cell and Bombyx mori larvae expression syst...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1136-z
更新日期：2018-01-01 00:00:00
abstract：:A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenet...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-020-01457-y
更新日期：2021-01-01 00:00:00
abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. H...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0484-8
更新日期：2011-04-01 00:00:00
abstract：:In recent years, Spirulina has gained more and more attention from medical scientists as a nutraceutical and a source of potential pharmaceuticals. The present study was conducted to elucidate the immunomodulatory effect of Spirulina fusiformis (a cyanobacterium of the family Oscillatoriaceae) in vivo and in vitro. Th...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0308-2
更新日期：2009-04-01 00:00:00
abstract：:Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as r...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0998-9
更新日期：2016-07-01 00:00:00
abstract：:Four hydrolyzable tannins [oenothein B (1), eugeniflorin D(2) (2), and tellimagrandins I (3) and II (4)], two related polyphenolic compounds [gallic acid (5) and quinic acid 3,5-di-O-gallate (6)], and four myricetin glycosides [myricetins 3-O-beta-D-xyloside (7), 3-O-beta-D-galactoside (8), 3-O-beta-D-galactoside 6''-...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0251-2
更新日期：2008-07-01 00:00:00
abstract：:This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory a...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0224-x
更新日期：2008-04-01 00:00:00
abstract：:It has been found by ribosomal DNA analysis that the endophytic filamentous fungi isolated from the tea plant Camellia sinensis (Theaceae) are composed of six groups; one Fusarium sp., one Penicillium sp., two Schizophyllum sp., and two Diaporthe sp.. ...
journal_title：Journal of natural medicines
pub_type： 社论
doi：10.1007/s11418-006-0038-2
更新日期：2006-07-01 00:00:00
abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0795-7
更新日期：2014-04-01 00:00:00
abstract：:A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falcip...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0574-2
更新日期：2012-04-01 00:00:00
abstract：:Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eigh...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0287-3
更新日期：2009-01-01 00:00:00
abstract：:Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-01279-z
更新日期：2019-06-01 00:00:00
abstract：:Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a basta...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-006-0045-3
更新日期：2006-07-01 00:00:00
abstract：:An acyclic diterpene (plaunotol; 1) and two furanoditerpenes (plaunolide, 2 and plaunol E, 3), were isolated from Croton stellatopilosus leaves, and assessed for their inhibitory activity on nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 cells. Plaunotol, plaunolide and plaunol E exhibited i...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0668-5
更新日期：2013-01-01 00:00:00
abstract：:Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0605-z
更新日期：2012-04-01 00:00:00
abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0996-y
更新日期：2016-07-01 00:00:00
abstract：:Two novel monoterpenes, sibiscolacton (1) and sibiraic acid (2), were isolated from the aerial part of Sibiraea angustata RCHD: . along with seven known compounds, namely three phenylpropanoids (3-5), two flavonoids (6,7), one glucityl ferulate (8, sibirate), and a monoterpene glucoside (9, sibiskoside). The structure...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0362-4
更新日期：2010-01-01 00:00:00
abstract：:Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0677-4
更新日期：2013-04-01 00:00:00
abstract：:Three new acetylated C-glycosylflavones, 3″,6″-di-O-acetylswertiajaponin (1), 4″,6″-di-O-acetylswertiajaponin (2), and 6″-O-acetylswertiajaponin (3), together with six known compounds were isolated from the whole herb of Swertia mileensis. Their structures were elucidated on extensive NMR experiments and mass spectrom...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1225-7
更新日期：2018-09-01 00:00:00
abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0177-0
更新日期：2008-01-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0885-9
更新日期：2015-07-01 00:00:00
abstract：:Six cycloartane glycosides, named tareciliosides N-S, and a known iridoid glucoside, ixoroside, were isolated in further extensive studies on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Tarenna gracilipes. From the EtOAc-soluble fraction, three known triterpenes were isolated. Their toxicities towar...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0707-2
更新日期：2013-07-01 00:00:00
abstract：:Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xant...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01376-7
更新日期：2020-03-01 00:00:00
abstract：:Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-1055-4
更新日期：2017-01-01 00:00:00
