Abstract:
:Four new cucurbitane-type triterpenes were isolated from the fruit of Momordica charantia L. The structures of the new compounds were identified based on HR-ESI-MS and 1D- and 2D-NMR spectroscopic methods. The cytotoxicity of the isolated compounds was evaluated using three human cancer cell lines, HeLa, Caco2, and U87. Compound 3 exhibited significant cytotoxic activity against HeLa cells with an IC50 value of 11.18 μM. Additionally, the cytoprotective activity of these compounds was determined in vitro against H2O2-induced pancreatic injury. The results revealed that all the compounds obtained possess cytoprotective effects against H2O2-induced injury in MIN6 β-cells at a concentration of 10 μM.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Yue J,Sun Y,Xu J,Zhang X,Zhao Ydoi
10.1007/s11418-019-01336-1subject
Has Abstractpub_date
2020-01-01 00:00:00pages
34-40issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-019-01336-1journal_volume
74pub_type
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