Abstract：
:Ceramicines are a series of limonoids which were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and show various biological activities. Ceramicine B, in particular, has been reported to show a strong lipid droplet accumulation (LDA) inhibitory activity on a mouse pre-adipocyte cell line (MC3T3-G2/PA6). With the purpose of discovering compounds with stronger activity than ceramicine B, we further investigated the constituents of C. ceramicus. As a result, from the bark of C. ceramicus four new ceramicines (ceramicines M-P, 1-4) were isolated, and their structures were determined on the basis of NMR and mass spectroscopic analyses in combination with NMR chemical shift calculations. LDA inhibitory activity of 1-4 was evaluated. Compounds 1-3 showed LDA inhibitory activity, and 3 showed better selectivity than ceramicine B while showing activity at the same order of magnitude as ceramicine B. Since 3, which possess a carbonyl group at C-7, showed better selectivity than 5, which possess a 7α-OH group, while showing activity at the same order of magnitude as 5, we also investigated the effect of the substituent at C-7 by synthesizing several derivatives and evaluating their LDA inhibitory activity. Accordingly, we confirmed the importance of the presence of a 7α-OH group to the LDA inhibitory activity.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Nugroho AE,Hashimoto A,Wong CP,Yokoe H,Tsubuki M,Kaneda T,Hadi AHA,Morita Hdoi
10.1007/s11418-017-1109-2subject
Has Abstractpub_date
2018-01-01 00:00:00pages
64-72issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-017-1109-2journal_volume
72pub_type
杂志文章abstract：:The purpose of the study was to evaluate the suppressive effect of TJ-68 on duodenal spasms during endoscopic retrograde cholangiopancreatography (ERCP). At the point when the duodenal papilla was confirmed after insertion of the endoscope during ERCP, 5.0 g TJ-68 (Tsumura Co., Tokyo, Japan) was dissolved in 50 ml of ...
journal_title：Journal of natural medicines
pub_type： 临床试验,杂志文章
doi：10.1007/s11418-008-0304-6
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abstract：:The known seco-cucurbitane triterpene, (24E)-3,4-seco-cucurbita-4,24-diene-3,26,29-trioic acid (1), has been isolated as a potent protein tyrosine phosphatase (PTP) 1B inhibitor together with a new analogue, (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid (2), from the fruiting bodies of Russula lepida....
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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pub_type： 杂志文章
doi：10.1007/s11418-018-1175-0
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0193-0
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journal_title：Journal of natural medicines
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0491-9
更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0297-1
更新日期：2009-04-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2006-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0703-6
更新日期：2013-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01332-5
更新日期：2020-01-01 00:00:00
