Abstract:
:Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1-2) with six known congeners (3-8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit through a dioxane bridge, respectively. Their structures were determined by comprehensive NMR spectroscopic data, the absolute configuration of new compounds were determined by comparing their experimental and calculated ECD for the first time. All the compounds were investigated contains two cancer cell lines (HI-60, THP-1). All the isolates showed cytotoxicity, especially compound 4 showed markedly cytotoxic activities against HI-60 and THP-1 cell lines with IC50 values of 11.96 and 8.92 μM.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Zhao GY,Deng BW,Zhang CY,Cui YD,Bi JY,Zhang GGdoi
10.1007/s11418-017-1141-2subject
Has Abstractpub_date
2018-01-01 00:00:00pages
246-251issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-017-1141-2journal_volume
72pub_type
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