当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > The transcriptome of the adenovirus infected cell.

The transcriptome of the adenovirus infected cell.

Abstract：

:Alternations of cellular gene expression following an adenovirus type 2 infection of human primary cells were studied by using superior sensitive cDNA sequencing. In total, 3791 cellular genes were identified as differentially expressed more than 2-fold. Genes involved in DNA replication, RNA transcription and cell cycle regulation were very abundant among the up-regulated genes. On the other hand, genes involved in various signaling pathways including TGF-β, Rho, G-protein, Map kinase, STAT and NF-κB stood out among the down-regulated genes. Binding sites for E2F, ATF/CREB and AP2 were prevalent in the up-regulated genes, whereas binding sites for SRF and NF-κB were dominant among the down-regulated genes. It is evident that the adenovirus has gained a control of the host cell cycle, growth, immune response and apoptosis at 24 h after infection. However, efforts from host cell to block the cell cycle progression and activate an antiviral response were also observed.

journal_name

Virology

journal_title

Virology

authors

Zhao H,Dahlö M,Isaksson A,Syvänen AC,Pettersson U

doi

10.1016/j.virol.2011.12.006

subject

Has Abstract

pub_date

2012-03-15 00:00:00

pages

115-28

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(11)00564-2

journal_volume

424

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Sequences of the N and M genes of the sigma virus of Drosophila and evolutionary comparison.

    abstract：:The genome of the sigma rhabdovirus of Drosophila melanogaster consists of six genes in the order 3' N-2-3-4-G-L 5'. The nucleotide sequences of the N and of the fourth genes were determined from cDNA clones. Each gene contained a single long open reading frame encoding polypeptides with predicted MW of 50 and 25 kDa,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1177

    authors： Bras F,Teninges D,Dezelee S

    更新日期：1994-04-01 00:00:00

  • The neutralizing antibody response against West Nile virus in naturally infected horses.

    abstract：:A major neutralizing epitope (here referred to as the T332 epitope) located on the lateral surface of domain III (DIII) of the West Nile virus (WNV) envelope protein has been identified based on the analysis of murine monoclonal antibodies. However, little is known about the humoral immune response against WNV in a na...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.08.047

    authors： Sánchez MD,Pierson TC,Degrace MM,Mattei LM,Hanna SL,Del Piero F,Doms RW

    更新日期：2007-03-15 00:00:00

  • The antimicrobial peptide HS-1 inhibits dengue virus infection.

    abstract：:Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, deri...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.11.009

    authors： Monteiro JMC,Oliveira MD,Dias RS,Nacif-Marçal L,Feio RN,Ferreira SO,Oliveira LL,Silva CC,Paula SO

    更新日期：2018-01-15 00:00:00

  • Zoonotic potential of highly pathogenic avian H7N3 influenza viruses from Pakistan.

    abstract：:H5 and H7 avian influenza viruses can become highly pathogenic in chickens after interspecies transmission. These viruses have transmitted directly to humans from birds in Eurasia and Africa (H5N1), the Netherlands (H7N7), and Canada (H7N3). Here we report antigenic, sequence, and phylogenetic analyses of H7N3 viruses...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.05.008

    authors： Aamir UB,Naeem K,Ahmed Z,Obert CA,Franks J,Krauss S,Seiler P,Webster RG

    更新日期：2009-08-01 00:00:00

  • Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice.

    abstract：:Fixed rabies virus strains (ERA and CVS) produce a fatal paralytic disease in mice after intracerebral or intramuscular injection. Some antigenic mutants of both CVS and ERA viruses with a substitution in position 333 of the glycoprotein (arginine is replaced either by a glutamine, a glycine, or an isoleucine) are tot...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90122-0

    authors： Tuffereau C,Leblois H,Bénéjean J,Coulon P,Lafay F,Flamand A

    更新日期：1989-09-01 00:00:00

  • Structural characterization of the PCV2d virus-like particle at 3.3 Å resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes.

    abstract：:Porcine circovirus 2 (PCV2) has a major impact on the swine industry. Eight PCV2 genotypes (a-h) have been identified using capsid sequence analysis. PCV2d has been designated as the emerging genotype. The cryo-electron microscopy molecular envelope of PCV2d virus-like particles identifies differences between PCV2a, b...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.09.001

    authors： Khayat R,Wen K,Alimova A,Gavrilov B,Katz A,Galarza JM,Gottlieb P

    更新日期：2019-11-01 00:00:00

  • The inhibitory effect of RANTES on the infection of primary macrophages by R5 human immunodeficiency virus type-1 depends on the macrophage activation state.

    abstract：:We investigated whether culture conditions could affect the RANTES antiviral effect on human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages. Monocyte-derived macrophages (MDM) were obtained either as (1) the adherent cells of 5-day cultures of blood mononuclear cells (PBMC), followed by 2 days ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9452

    authors： Amzazi S,Ylisastigui L,Bakri Y,Rabehi L,Gattegno L,Parmentier M,Gluckman JC,Benjouad A

    更新日期：1998-12-05 00:00:00

  • Mutations in a satellite RNA of turnip crinkle virus result in addition of poly(U) in vivo.

    abstract：:Turnip crinkle virus (TCV) is associated with many subviral RNAs including satellite (sat-) RNAs which require a helper virus for infectivity. When plants were inoculated with TCV and transcripts of TCV sat-RNA C containing deletions of 3 to 8 nucleotides beginning at position 100 and extending toward the 5' end, some...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90988-n

    authors： Carpenter CD,Cascone PJ,Simon AE

    更新日期：1991-08-01 00:00:00

  • Adaptation of measles virus to polarized epithelial cells: alterations in virus entry and release.

    abstract：:We have previously shown that the Edmonston strain of measles virus enters and is released preferentially at the apical surfaces of polarized epithelial cells. Small amounts of virus were found to be released at the basal surface. In the present study, we passaged the virus in polarized cells and characterized the pas...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8520

    authors： Blau DM,Compans RW

    更新日期：1997-05-12 00:00:00

  • Phosphorylated proteins in cauliflower mosaic virus.

    abstract：:Autoradiography of dodecyl sulfate-impregnated polyacrylamide gels after electrophoresis of the proteins from 32P-labeled cauliflower mosaic virus (CaMV) showed that two of the structural proteins were phosphorylated. These two proteins of 44 and 58 kilodaltons (kd) occur as minor components with some strains of the v...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(80)90294-9

    authors： Hahn P,Shepherd RJ

    更新日期：1980-11-01 00:00:00

  • Formation of phage T1 concatemers by the RecE recombination pathway of Escherichia coli.

    abstract：:Infections of nonpermissive ( sup0 ) Escherichia coli by T1 phage with amber mutations in either gene 3.5 or gene 4 exhibit a variety of defective phenotypes, including premature arrest of T1 DNA synthesis, failure to make concatemeric DNA, formation of an abnormal DNA replication intermediate, failure to package phag...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90130-2

    authors： Pugh JC,Ritchie DA

    更新日期：1984-05-01 00:00:00

  • Myb protein binds to multiple sites in the human T cell lymphotropic virus type 1 long terminal repeat and transactivates LTR-mediated expression.

    abstract：:The members of the c-myb proto-oncogene family encode sequence-specific transcriptional activators. In T cells, expression of c-myb and the related B-myb gene is induced following mitogenic stimulation. Using a purified recombinant protein, we report here that the human T cell lymphotropic virus type 1 (HTLV-1) LTR c...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90044-p

    authors： Bosselut R,Lim F,Romond PC,Frampton J,Brady J,Ghysdael J

    更新日期：1992-02-01 00:00:00

  • Cellular basis of potato spindle tuber viroid systemic movement.

    abstract：:Viroids are small, nontranslatable pathogenic RNAs that replicate autonomously and traffic systemically in their host plants. We have used in situ hybridization to analyze the trafficking pattern of Potato spindle tuber viroid (PSTVd) in tomato and Nicotiana benthamiana. When PSTVd was inoculated onto the stem of a pl...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0724

    authors： Zhu Y,Green L,Woo YM,Owens R,Ding B

    更新日期：2001-01-05 00:00:00

  • Primary structure of brome mosaic virus coat protein.

    abstract：:The amino acid sequence of BMV (brome mosaic virus) coat protein is presented and compared with the sequence derived from RNA structure. Apart from removal of the N-terminal methionine residue and acetylation of the following serine residue, no post-translational modifications occur. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90193-9

    authors： Moosic JP,McKean DJ,Shih DS,Kaesberg P

    更新日期：1983-09-01 00:00:00

  • Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation.

    abstract：:Plasmids containing the E1 region of Ad12 DNA can transform certain rodent cells into oncogenic cells. To study the role of the E1a subregion in the process of oncogenic transformation, Ad12 region E1 mutants carrying deletions in the E1a region were constructed. Deletion mutants pR7 and pR8 affect only the 13 S mRNA ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90178-2

    authors： Bos JL,Jochemsen AG,Bernards R,Schrier PI,van Ormondt H,van der Eb AJ

    更新日期：1983-09-01 00:00:00

  • Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N.

    abstract：:Porcine epidemic diarrhea virus (PEDV) is a causative agent of porcine epidemic diarrhea (PED). PED, characterized by acute diarrhea, vomiting, dehydration, has caused serious economic losses in pig industry worldwide. Here, we demonstrate that activation of a disintergrin and metalloprotease 17 (ADAM17) induced the d...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.02.001

    authors： Zhang J,Guo L,Yang L,Xu J,Zhang L,Feng L,Chen H,Wang Y

    更新日期：2018-04-01 00:00:00

  • Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.

    abstract：:The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rH...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.011

    authors： Schaap-Nutt A,D'Angelo C,Amaro-Carambot E,Nolan SM,Davis S,Wise SM,Higgins C,Bradley K,Kim O,Mayor R,Skiadopoulos MH,Collins PL,Murphy BR,Schmidt AC

    更新日期：2010-10-10 00:00:00

  • Characterization of a MH2 mutant lacking the v-myc oncogene.

    abstract：:We have previously reported that a virus, MH2-PA200, lacking the ability to transform quail embryo cells, could be isolated from wild type (wt) MH2 stocks passaged on chicken neuroretina cells. We report here the molecular cloning and extensive characterization of this MH2-PA200 provirus. Molecularly cloned MH2-PA200 ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90030-9

    authors： Martin P,Henry C,Denhez F,Amouyel P,Bechade C,Calothy G,Debuire B,Stehelin D,Saule S

    更新日期：1986-09-01 00:00:00

  • Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation.

    abstract：:The influenza virus mRNAs are structurally similar to cellular mRNAs nevertheless; the virus promotes selective translation of viral mRNAs despite the inhibition of host cell protein synthesis. The infection proceeds normally upon functional impairment of eIF4E cap-binding protein, but requires functional eIF4A helica...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.10.028

    authors： Yángüez E,Rodriguez P,Goodfellow I,Nieto A

    更新日期：2012-01-20 00:00:00

  • Identification of a Hyphantria cunea nucleopolyhedrovirus (NPV) gene that is involved in global protein synthesis shutdown and restricted Bombyx mori NPV multiplication in a B. mori cell line.

    abstract：:We previously demonstrated that Bombyx mori nucleopolyhedrovirus (BmNPV) multiplication is restricted in permissive BmN-4 cells upon coinfection with Hyphantria cunea NPV (HycuNPV). Here, we show that HycuNPV-encoded hycu-ep32 gene is responsible for the restricted BmNPV multiplication in HycuNPV-coinfected BmN-4 cell...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.11.049

    authors： Shirata N,Ikeda M,Kobayashi M

    更新日期：2010-03-15 00:00:00

  • Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells.

    abstract：:Epstein-Barr virus (EBV) is a herpesvirus that transforms B-cells (B-LCL) and has undergone intense scrutiny owing to its association with Burkitt's lymphoma, nasopharyngeal carcinoma, and immunoblastic lymphomas. B-LCL have also proven useful in the study of human immunology. We describe a novel system for inducing e...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1069

    authors： Curiel TJ,Cook DR,Bogedain C,Jilg W,Harrison GS,Cotten M,Curiel DT,Wagner E

    更新日期：1994-02-01 00:00:00

  • Baculoviruses deficient in ie1 gene function abrogate viral gene expression in transduced mammalian cells.

    abstract：:One of the newest niches for baculoviruses-based technologies is their use as vectors for mammalian cell transduction and gene therapy applications. However, an outstanding safety issue related to such use is the residual expression of viral genes in infected mammalian cells. Here we show that infectious baculoviruses...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.020

    authors： Efrose R,Swevers L,Iatrou K

    更新日期：2010-10-25 00:00:00

  • Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage.

    abstract：:Endogenous feline leukemia viruses (enFeLVs) occur in the germ lines of the domestic cat and related wild species (genus Felis). We sequenced the long terminal repeats and part of the env region of enFeLVs in domestic cats and five wild species. A total of 305 enFeLV sequences were generated across 17 individuals, dem...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.06.010

    authors： Polani S,Roca AL,Rosensteel BB,Kolokotronis SO,Bar-Gal GK

    更新日期：2010-09-30 00:00:00

  • Emergence of influenza A H1N2 reassortant viruses in the human population during 2001.

    abstract：:Influenza A H1N2 viruses, which emerged during 2001, are genetic reassortants between H1N1 and H3N2 subtype viruses which have cocirculated in the human population since 1977. They possess a H1 hemagglutinin antigenically and genetically similar to contemporary A/New Caledonia/20/99 (H1N1)-like viruses and seven genes...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1513

    authors： Gregory V,Bennett M,Orkhan MH,Al Hajjar S,Varsano N,Mendelson E,Zambon M,Ellis J,Hay A,Lin YP

    更新日期：2002-08-15 00:00:00

  • The secretory cells of mouse salivary glands are nonpermissive for polyomavirus replication.

    abstract：:Parotid tumor agent was an early name for polyomavirus due to its ability to induce tumors (myoepitheliomas originating from the myoepithelial glandular tissues) in mice inoculated with polyomavirus (Py) as neonates. It has long been thought that these tumors directly follow productive infection by Py in epithelial ce...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1254

    authors： Atencio IA,Meraz A,Villarreal LP

    更新日期：1994-05-01 00:00:00

  • Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.

    abstract：:Treatment with HIV attachment inhibitors (AIs) can select for escape mutants throughout the viral envelope. We report on three such mutations: F423Y (gp120 CD4 binding pocket) and I595F and K655E (gp41 ectodomain). Each displayed decreased sensitivity to the AI BMS-488043 and earlier generation AIs, along with increas...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.03.033

    authors： Zhou N,Fan L,Ho HT,Nowicka-Sans B,Sun Y,Zhu Y,Hu Y,McAuliffe B,Rose B,Fang H,Wang T,Kadow J,Krystal M,Alexander L,Colonno R,Lin PF

    更新日期：2010-07-05 00:00:00

  • Analysis of the role of the amino-terminal peptide of vaccinia virus structural protein precursors during proteolytic processing.

    abstract：:Several VV structural proteins are produced by the removal of amino-terminal peptides from their cognate precursors. In the experiments reported here, directed genetic approaches were used to investigate the possible role of these terminal peptides in protein processing. As a model system, the FLAG epitope-tagged P25K...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1069

    authors： Lee P,Hruby DE

    更新日期：1995-02-20 00:00:00

  • Conserved amino acids of the human immunodeficiency virus type 2 Vpx nuclear localization signal are critical for nuclear targeting of the viral preintegration complex in non-dividing cells.

    abstract：:The HIV-2 viral accessory protein Vpx is related to, but distinct from the Vpr protein of HIV-1. Vpx is packaged into virions and as a component of the viral preintegration complex (PIC) is required for efficient virus replication in non-dividing cells. We have previously reported that the minimal transferable region ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.10.036

    authors： Belshan M,Mahnke LA,Ratner L

    更新日期：2006-03-01 00:00:00

  • Cross-clade neutralizing antibodies against HIV-1 induced in rabbits by focusing the immune response on a neutralizing epitope.

    abstract：:Studies were performed to induce cross-clade neutralizing antibodies (Abs) by testing various combinations of prime and boost constructs that focus the immune response on structurally-conserved epitopes in the V3 loop of HIV-1 gp120. Rabbits were immunized with gp120 DNA containing a V3 loop characterized by the GPGR ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.05.039

    authors： Zolla-Pazner S,Cohen S,Pinter A,Krachmarov C,Wrin T,Wang S,Lu S

    更新日期：2009-09-15 00:00:00

  • The hypervariable region 1 protein of hepatitis C virus broadly reactive with sera of patients with chronic hepatitis C has a similar amino acid sequence with the consensus sequence.

    abstract：:Hypervariable region 1 (HVR1) proteins of hepatitis C virus (HCV) have been reported to react broadly with sera of patients with HCV infection. However, the variability of the broad reactivity of individual HVR1 proteins has not been elucidated. We assessed the reactivity of 25 different HVR1 proteins (genotype 1b) wi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0004

    authors： Watanabe K,Yoshioka K,Ito H,Ishigami M,Takagi K,Utsunomiya S,Kobayashi M,Kishimoto H,Yano M,Kakumu S

    更新日期：1999-11-10 00:00:00