The hypervariable region 1 protein of hepatitis C virus broadly reactive with sera of patients with chronic hepatitis C has a similar amino acid sequence with the consensus sequence.

abstract：:The proteins encoded by open reading frame 3 (ORF3) of the umbraviruses pea enation mosaic virus-2 and tobacco mottle virus, like that of groundnut rosette virus, mediated the movement of viral RNA through the phloem of infected Nicotiana benthamiana or N. clevelandii plants when they were expressed from chimeric toba...

journal_title：Virology

authors： Ryabov EV,Robinson DJ,Taliansky M

更新日期：2001-09-30 00:00:00

abstract：:Purification of the putative cowpea mosaic virus (CPMV) RNA replicase previously started with an RNA-dependent RNA polymerase activity which had been solubilized from a crude membrane fraction of CPMV-infected cowpea leaves by extraction with a Mg2+-deficient buffer. This led to the identification of a host-encoded, 1...

journal_title：Virology

authors： Dorssers L,van der Meer J,Van Kammen A,Zabel P

更新日期：1983-02-01 00:00:00

abstract：:We have previously reported that a virus, MH2-PA200, lacking the ability to transform quail embryo cells, could be isolated from wild type (wt) MH2 stocks passaged on chicken neuroretina cells. We report here the molecular cloning and extensive characterization of this MH2-PA200 provirus. Molecularly cloned MH2-PA200 ...

journal_title：Virology

authors： Martin P,Henry C,Denhez F,Amouyel P,Bechade C,Calothy G,Debuire B,Stehelin D,Saule S

更新日期：1986-09-01 00:00:00

abstract：:The genome of peanut clump pecluvirus (PCV) consists of two messenger RNA components which contain, respectively, three and five open reading frames (ORFs). Inoculation of transcripts from full-length cDNA clones derived from the PCV RNAs showed that RNA-1 is able to replicate in the absence of RNA-2 in protoplasts, b...

journal_title：Virology

authors： Herzog E,Hemmer O,Hauser S,Meyer G,Bouzoubaa S,Fritsch C

更新日期：1998-09-01 00:00:00

abstract：:The Rice stripe virus (RSV) pc4 has been determined as the viral movement protein (MP). In this study, the pc4 gene was cloned into a movement-deficient Tobacco mosaic virus (TMV). The resulting hybrid TMV-pc4, in addition to spreading cell to cell in Nicotiana tabacum, moved systemically and induced foliar necrosis i...

journal_title：Virology

authors： Zhang C,Pei X,Wang Z,Jia S,Guo S,Zhang Y,Li W

更新日期：2012-04-10 00:00:00

abstract：:The major late promoter (MLP) of the subgroup C human adenoviruses is a preeminent model for the study of the mechanisms of basal and activated transcription, both in vivo and in vitro. However, while the structure and function of the human virus MLP has been the subject of extensive investigation, the conservation of...

journal_title：Virology

authors： Song B,Hu SL,Darai G,Spindler KR,Young CS

更新日期：1996-06-15 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) UL37 open reading frame encodes a 120-kDa late (gamma 1) phosphoprotein in infected cells. Analysis of isolated mature HSV virions and light particles revealed that the UL37 protein is a component of the virion. Detergent solubilization and protease digestion experiments suggest...

journal_title：Virology

authors： Schmitz JB,Albright AG,Kinchington PR,Jenkins FJ

更新日期：1995-02-01 00:00:00

abstract：:Encephalomyocarditis virus (EMCV) is the prototype member of the cardiovirus genus of picornaviruses. For cardioviruses and the related aphthoviruses, the first protein segment translated from the plus-strand RNA genome is the Leader protein. The aphthovirus Leader (173-201 amino acids) is an autocatalytic papain-like...

journal_title：Virology

authors： Dvorak CM,Hall DJ,Hill M,Riddle M,Pranter A,Dillman J,Deibel M,Palmenberg AC

更新日期：2001-11-25 00:00:00

abstract：:Activation of the minute virus of mice (MVM) P4 promoter is a key step in the life cycle of the virus and is completely dependent on host transcription factors. Since transcription-factor composition varies widely in different cell types, there is the possibility that only some cell types in the host organism have the...

journal_title：Virology

authors： Davis C,Segev-Amzaleg N,Rotem I,Mincberg M,Amir N,Sivan S,Gitelman I,Tal J

更新日期：2003-02-15 00:00:00

abstract：:Equine herpesvirus 1 (EHV-1) recombinants that carry either a deletion of glycoprotein M (gM) or express mutant forms of gM were constructed. The recombinants were derived from strain Kentucky A (KyA), which also lacks genes encoding gE and gI. Plaques on RK13 cells induced by the gM-negative KyA were reduced in size ...

journal_title：Virology

authors： Seyboldt C,Granzow H,Osterrieder N

更新日期：2000-12-20 00:00:00

abstract：:In a previous paper (G. Winkler, V. B. Randolph, G. R. Cleaves, T. E. Ryan, and V. Stollar, 1988, Virology 162, 187-196) we showed that the newly synthesized dengue-2 virus nonstructural protein, NS1, exists briefly as a monomer and then undergoes dimerization. We demonstrate here that the dimerization of NS1 is assoc...

journal_title：Virology

authors： Winkler G,Maxwell SE,Ruemmler C,Stollar V

更新日期：1989-07-01 00:00:00

abstract：:Unusual Plum pox virus (PPV) isolates (named Tat isolates) were discovered on sour cherry (Prunus cerasus) in Russia. They failed to be recognized by RT-PCR using commonly employed primers specific to the strains C or CR (the only ones that proved able to infect sour cherry) as well as to the strains M and W. Some of ...

journal_title：Virology

authors： Chirkov S,Ivanov P,Sheveleva A,Zakubanskiy A,Osipov G

更新日期：2017-02-01 00:00:00

abstract：:The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potenc...

journal_title：Virology

authors： Bates JT,Keefer CJ,Slaughter JC,Kulp DW,Schief WR,Crowe JE Jr

更新日期：2014-04-01 00:00:00

abstract：:Oral transmission of human immunodeficiency virus (HIV) in adult populations is rare. However, HIV spread across fetal/neonatal oropharyngeal epithelia could be important in mother-to-child transmission. Analysis of HIV transmission across polarized adult and fetal oral epithelial cells revealed that HIV transmigrates...

journal_title：Virology

authors： Tugizov SM,Herrera R,Veluppillai P,Greenspan D,Soros V,Greene WC,Levy JA,Palefsky JM

更新日期：2011-01-20 00:00:00

abstract：:The bottom component B1a of TYMV with a buoyant density of 1.42-1.43 g/ml, is converted to a more dense particle B2a following CsCI density gradient centrifugation. This conversion is complete after a prior incubation of the virus in the CsCl solution at elevated temperatures. It is shown that the formation of B28 is ...

journal_title：Virology

authors： Noort A,van den Dries CL,Pleij CW,Jaspars EM,Bosch L

更新日期：1982-07-30 00:00:00

abstract：:The members of the c-myb proto-oncogene family encode sequence-specific transcriptional activators. In T cells, expression of c-myb and the related B-myb gene is induced following mitogenic stimulation. Using a purified recombinant protein, we report here that the human T cell lymphotropic virus type 1 (HTLV-1) LTR c...

journal_title：Virology

authors： Bosselut R,Lim F,Romond PC,Frampton J,Brady J,Ghysdael J

更新日期：1992-02-01 00:00:00

abstract：:Genome-length cDNA clones of turnip crinkle virus (TCV) were constructed with SmaI and XbaI restriction sites engineered at the 5' and 3' termini, respectively. The genome-length cDNAs were positioned downstream of modified lambda and T7 phage promoters such that in vitro transcription resulted in RNAs with 5 extra nu...

journal_title：Virology

authors： Heaton LA,Carrington JC,Morris TJ

更新日期：1989-05-01 00:00:00

abstract：:The nucleotide sequence of the portion of naturally occurring defective EBV (HR-1) DNA (designated het DNA) which is responsible for disruption of EBV latency has been determined and compared with the regions of the standard HR-1 viral genome from which it was derived. This rearranged 2.7-kbp DNA fragment represented ...

journal_title：Virology

authors： Jenson HB,Miller G

更新日期：1988-08-01 00:00:00

abstract：:Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated. We investigated the role of the intron within the Fr-MLV gene in Env expression using vectors with serially truncated introns. The up-regulatory regions, the 361-878 and the 5135-5399 ...

journal_title：Virology

authors： Yamamoto N,Takase-Yoden S

更新日期：2009-03-01 00:00:00

abstract：:The pathogenesis of two Californian strains of myxoma virus (MSW and MSD) was examined in European rabbits (Oryctolagus cuniculus) that were either susceptible to myxomatosis (laboratory rabbits) or had undergone natural selection for genetic resistance to myxomatosis (Australian wild rabbits). MSW was highly lethal f...

journal_title：Virology

authors： Silvers L,Inglis B,Labudovic A,Janssens PA,van Leeuwen BH,Kerr PJ

更新日期：2006-04-25 00:00:00

abstract：:Human noroviruses bind histo-blood group antigens (HBGAs) and this interaction is thought to be important for an infection. We identified two additional fucose-binding pockets (termed fucose-3/4 sites) on a genogroup II human (GII.10) norovirus-protruding (P) dimer using X-ray crystallography. Fucose-3/4 sites were lo...

journal_title：Virology

authors： Koromyslova AD,Leuthold MM,Bowler MW,Hansman GS

更新日期：2015-09-01 00:00:00

abstract：:We expressed the carboxy-terminal portion of the E2 open reading frame (ORF)-encoded protein of human papillomavirus type 16 (HPV-16) and purified it to near homogeneity. Using DNase I footprinting techniques, we show that like the homologous protein from bovine papillomavirus type 1 (BPV-1), HPV-18, HPV-11, it binds ...

journal_title：Virology

authors： Bedrosian CL,Bastia D

更新日期：1990-02-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV 16) is often found in cervical carcinomas, while HPV 6 is frequently associated with benign genital lesions. We have compared the abilities of the E7 transforming proteins of HPV 6 and 16 to transform various established and primary rodent cells by using the same heterologous promoter...

journal_title：Virology

authors： Takami Y,Sasagawa T,Sudiro TM,Yutsudo M,Hakura A

更新日期：1992-02-01 00:00:00

abstract：:Hepatitis B virus synthesizes multiple spliced RNAs that can be reverse transcribed into viral DNA. We thoroughly characterized the contribution of spliced RNAs to DNA synthesis in transfected cultures of Huh7 and HepG2 cells. We found that up to 50% of DNA within intracellular capsids is derived from five spliced RNA...

journal_title：Virology

authors： Abraham TM,Lewellyn EB,Haines KM,Loeb DD

更新日期：2008-09-15 00:00:00

abstract：:The Chlorella virus PBCV-1 genome is a linear nonpermuted 333-kbp dsDNA molecule with covalently closed hairpin termini. The termini (minus the hairpin) are identical inverted repeats of at least 2185 bases after which the sequence diverges. The inverted repeats contain two small potential open reading frames and seve...

journal_title：Virology

authors： Strasser P,Zhang YP,Rohozinski J,Van Etten JL

更新日期：1991-02-01 00:00:00

abstract：:Tick-borne flaviviruses are maintained in nature in an enzootic cycle involving a tick vector and a vertebrate host. Thus, the virus replicates in two disparate hosts, each providing selective pressures that can influence virus replication and pathogenicity. To identify viral determinants associated with replication i...

journal_title：Virology

authors： Mitzel DN,Best SM,Masnick MF,Porcella SF,Wolfinbarger JB,Bloom ME

更新日期：2008-11-25 00:00:00

abstract：:The red clover necrotic mosaic dianthovirus (RCNMV) genome is split between two single-stranded RNA species termed RNA-1 and RNA-2. RNA-2 is required for infection of whole plants but is dispensable for infection and virion formation in protoplasts. We have used full-length cDNA clones of RNA-1 and -2 from which infec...

journal_title：Virology

authors： Xiong Z,Kim KH,Giesman-Cookmeyer D,Lommel SA

更新日期：1993-01-01 00:00:00

abstract：:Naturally occurring mutations in Human T-cell Leukemia Virus Type 1 (HTLV-1) Tax protein lead to loss of recognition by cytotoxic T-lymphocytes. Most of these mutations also abolish or severely impair the transactivation function of Tax. Ninety percent of the rex gene, which encodes the viral regulator of mRNA splicin...

journal_title：Virology

authors： Smith RE,Niewiesk S,Booth S,Bangham CR,Daenke S

更新日期：1997-10-27 00:00:00

abstract：:From previously constructed genomic libraries of a Taiwan WSSV isolate, a putative WSSV tk-tmk gene was identified. Uniquely, the open reading frame (ORF) of this gene was predicted to encode a novel chimeric protein of 388 amino acids with significant homology to two proteins: thymidine kinase (TK) and thymidylate ki...

journal_title：Virology

authors： Tsai MF,Yu HT,Tzeng HF,Leu JH,Chou CM,Huang CJ,Wang CH,Lin JY,Kou GH,Lo CF

更新日期：2000-11-10 00:00:00

abstract：:We reported earlier that variable expression of the Epstein-Barr virus (EBV) encoded membrane protein LMP 1 in nasopharyngeal carcinoma and the host-cell-phenotype-dependent activity of the BCR2 promoter (one of the possible initiator sites for transcripts of Epstein-Barr nuclear antigens) in Burkitt's lymphoma (BL) l...

journal_title：Virology

authors： Minarovits J,Hu LF,Minarovits-Kormuta S,Klein G,Ernberg I

更新日期：1994-05-01 00:00:00