The relationship between cocaine self-administration and actigraphy-based measures of sleep in adult rhesus monkeys.

abstract：:To test the Pavlovian conditioning model of alcohol tolerance, two groups of eight male social drinkers each received five administrations of alcohol and five administrations of an equal volume of tonic each, on an alternating basis, during the initial 10-session tolerance development phase of the study. Group 1 recei...

journal_title：Psychopharmacology

authors： Shapiro AP,Nathan PE

更新日期：1986-01-01 00:00:00

abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...

journal_title：Psychopharmacology

authors： Rowlett JK,Woolverton WL

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...

journal_title：Psychopharmacology

authors： Roberts AJ,Casal L,Huitron-Resendiz S,Thompson T,Tarantino LM

更新日期：2018-04-01 00:00:00

abstract：RATIONALE:Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes in the central nervous system. Disturbed information processing as seen...

journal_title：Psychopharmacology

authors： Brosda J,Becker T,Richter M,Jakobs M,Hörbelt T,Bendix I,Lückemann L,Schedlowski M,Hadamitzky M

更新日期：2020-12-21 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00

abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...

journal_title：Psychopharmacology

authors： Kusumi I,Koyama T,Yamashita I

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

journal_title：Psychopharmacology

authors： Cardoso C,Ellenbogen MA,Linnen AM

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...

journal_title：Psychopharmacology

authors： Hart CL,Jatlow P,Sevarino KA,McCance-Katz EF

更新日期：2000-04-01 00:00:00

abstract：:The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Eth...

journal_title：Psychopharmacology

authors： You C,Vandegrift B,Brodie MS

更新日期：2018-06-01 00:00:00

abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...

journal_title：Psychopharmacology

authors： Duxon MS,Stretton J,Starr K,Jones DN,Holland V,Riley G,Jerman J,Brough S,Smart D,Johns A,Chan W,Porter RA,Upton N

更新日期：2001-01-01 00:00:00

abstract：:Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...

journal_title：Psychopharmacology

authors： Sanger DJ,Joly D,Zivkovic B

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is speculated that repeated exposure may produce drug dependence. OBJECTIVE:To investigate the effects of repe...

journal_title：Psychopharmacology

authors： dela Peña I,Yoon SY,Lee JC,dela Peña JB,Sohn AR,Ryu JH,Shin CY,Cheong JH

更新日期：2012-05-01 00:00:00

abstract：:Dose-related effects of ethanol (placebo, 0.30, and 0.60 g/kg) on behavioral and event-related brain potential (ERP) indices of involuntary attention shifting of audition were investigated. ERPs were recorded from 11 healthy social drinkers during a forced-choice reaction-time (RT) task. Subjects were presented with 1...

journal_title：Psychopharmacology

authors： Jääskeläinen IP,Schröger E,Näätänen R

更新日期：1999-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Addiction to psychostimulant methamphetamine (METH) remains a major public health problem in the world. Animal models that use METH self-administration incorporate many features of human drug-taking behavior and are very helpful in elucidating mechanisms underlying METH addiction. These models ...

journal_title：Psychopharmacology

authors： Krasnova IN,Justinova Z,Cadet JL

更新日期：2016-05-01 00:00:00

abstract：:m-Chlorophenylpiperazine (mCPP), a major metabolite of the atypical antidepressant trazadone, has been observed to produce marked physiological and behavioral effects in both humans and animals. These effects have been attributed to the interaction of mCPP with serotonergic receptors. The present study was designed to...

journal_title：Psychopharmacology

authors： Fiorella D,Rabin RA,Winter JC

更新日期：1995-05-01 00:00:00

abstract：:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...

journal_title：Psychopharmacology

authors： Jerussi TP,Glick SD

更新日期：1976-06-23 00:00:00

abstract：RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...

journal_title：Psychopharmacology

authors： Pritchard WS,Houlihan ME,Guy TD,Robinson JH

更新日期：1999-04-01 00:00:00

abstract：:Aggressive rats could be differentiated from non-aggressive rats on a lower rate of rearing reactions in the open-field activity, as well as on a weaker aptitude for learning, increasing with the complication of the test. The two groups of rats had comparable activity, and a comparable response to pain. Apomorphine de...

journal_title：Psychopharmacology

authors： Senault B

更新日期：1976-07-09 00:00:00

abstract：:Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulat...

journal_title：Psychopharmacology

authors： Meltzer HY,Kolakowska T,Robertson A,Tricou BJ

更新日期：1983-01-01 00:00:00

abstract：:Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). H...

journal_title：Psychopharmacology

authors： Cross AJ,Misra A,Sandilands A,Taylor MJ,Green AR

更新日期：1993-01-01 00:00:00

abstract：:Recent studies indicate that some aspects of memory can be enhanced by the administration of oxygen or glucose. Considering the dependency of glucose metabolism upon oxygen supply, the present study predicted that administering a combination of 100% oxygen with glucose would have greater memory-enhancing effects than ...

journal_title：Psychopharmacology

authors： Winder R,Borrill J

更新日期：1998-04-01 00:00:00

abstract：:An experiment was carried out in the pigeon to assess the effects of sodium amylobarbitone (SAB) on memory, using a delayed pair comparison task. Performance was disrupted at all delays by doses of 10 and 20 mg/kg SAB and it was concluded that this effect was not due to perceptual impairment or stereotyped responding,...

journal_title：Psychopharmacology

authors： Hulme M,Sahgal A,Iversen SD

更新日期：1979-03-29 00:00:00

abstract：RATIONALE:Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive deficits and negative symptoms. Dopamine D3 receptors are hi...

journal_title：Psychopharmacology

authors： Girgis RR,Slifstein M,D'Souza D,Lee Y,Periclou A,Ghahramani P,Laszlovszky I,Durgam S,Adham N,Nabulsi N,Huang Y,Carson RE,Kiss B,Kapás M,Abi-Dargham A,Rakhit A

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...

journal_title：Psychopharmacology

authors： Porter RJ,Gallagher P,Watson S,Smith MS,Young AH

更新日期：2003-08-01 00:00:00

abstract：:Pigs trained to avoid shocks by crossing a barrier in a shuttle-box according to a continuous avoidance procedure were submitted to a Pavlovian discriminative fear-conditioning procedure in which a tone was always followed by unavoidable shock (CS+) and another tone never followed by shock (CS-). The presentation of t...

journal_title：Psychopharmacology

authors： Dantzer R,Mormede P

更新日期：1976-08-26 00:00:00

abstract：RATIONALE:Carbon monoxide synthetized by inducible heme oxygenase (HO-1) exerts potent anti-inflammatory and antinociceptive effects during acute and neuropathic pain, but its role in the modulation of chronic inflammatory pain and the possible involvement of nitric oxide in this action remain unknown. OBJECTIVES AND ...

journal_title：Psychopharmacology

authors： Negrete R,Hervera A,Leánez S,Pol O

更新日期：2014-03-01 00:00:00

abstract：:The effect of postethanol treatment with L-Dopa, aminophylline and/or ephedrine was investigated. In one experiment, healthy, male, moderate drinkers ingested ethanol (0.8 g/kg) and then either L-Dopa (1.5 g), or placebo. In a second experiment, subjects ingested ethanol followed by aminophylline (200 mg), ephedrine (...

journal_title：Psychopharmacology

authors： Alkana RL,Parker ES,Cohen HB,Birch H,Noble EP

更新日期：1977-12-28 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：:The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...

journal_title：Psychopharmacology

authors： Härtter S,Arand M,Oesch F,Hiemke C

更新日期：1995-01-01 00:00:00

abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...

journal_title：Psychopharmacology

authors： Krafft K,Cleary J,Poling A

更新日期：1983-01-01 00:00:00