[Aggressive behaviour induced by apomorphine: relations with some elements of the behavioural profile and with the sensitivity to apomorphine (author's transl)].

abstract：RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...

journal_title：Psychopharmacology

authors： Tarland E,Franke RT,Fink H,Pertz HH,Brosda J

更新日期：2018-01-01 00:00:00

abstract：:Risperidone, a new antipsychotic agent, was studied for its effects on spontaneous motor activity in rats in comparison with haloperidol. Motor activity was recorded via the optical scanning technique (horizontal and vertical activity) and via a recently developed technique based on the piezo-electric principle which,...

journal_title：Psychopharmacology

authors： Megens AA,Awouters FH,Niemegeers CJ

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...

journal_title：Psychopharmacology

authors： Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...

journal_title：Psychopharmacology

authors： Atrens DM,Becker FT,Hunt GE

更新日期：1980-01-01 00:00:00

abstract：:DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing...

journal_title：Psychopharmacology

authors： Schmidt WJ

更新日期：1986-01-01 00:00:00

abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...

journal_title：Psychopharmacology

authors： Meller E

更新日期：1982-01-01 00:00:00

abstract：:Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...

journal_title：Psychopharmacology

authors： Parent MB,Habib MK,Baker GB

更新日期：1999-03-01 00:00:00

abstract：:Risperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed. Studies on the antagonism of the LSD-cue indicated that risperidone was able to completely block the discriminative stimulus properties of LSD wi...

journal_title：Psychopharmacology

authors： Meert TF,de Haes P,Janssen PA

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...

journal_title：Psychopharmacology

authors： Sukhtankar DD,Lee H,Rice KC,Ko MC

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Alcohol-associated cues elicit craving in human addicts but little is known about craving mechanisms. Current animal models focus on relapse and this may confound the effect of environmental cues. OBJECTIVES. To develop a model to study the effects of environmental cues on alcohol consumption in animals not e...

journal_title：Psychopharmacology

authors： Pickering C,Liljequist S

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:It has recently been reported that chronic nicotine administration at subconvulsive doses causes seizures, a phenomenon referred to as kindling. Evidence points to the involvement of oxidative stress in pharmacological and electrical kindling, sex is known to influence the brain's response to nicotine. OBJEC...

journal_title：Psychopharmacology

authors： Gomes PX,de Oliveira GV,de Araújo FY,de Barros Viana GS,de Sousa FC,Hyphantis TN,Grunberg NE,Carvalho AF,Macêdo DS

更新日期：2013-01-01 00:00:00

abstract：:Most post-mortem autoradiographic studies have described striatal dopamine D(2) receptor up-regulation due to chronic neuroleptic exposure. The aim of our study was to compare in-vivo striatal D(2) receptor density in neuroleptic-naive and neuroleptic-free schizophrenic patients. We included 28 young (mean age: 28+/-8...

journal_title：Psychopharmacology

authors： Lomeña F,Catafau AM,Parellada E,Bernardo M,Font M,Gutiérrez F,Pavía J

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. OBJECTIVE:We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regul...

journal_title：Psychopharmacology

authors： Takahashi A,Quadros IM,de Almeida RM,Miczek KA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Caveolin-1 (CAV1) is a structural protein critical for spatial organization of neuronal signaling molecules. Whether CAV1 is required for long-lasting neuronal plasticity remains unknown. OBJECTIVE AND METHODS:We sought to examine the effects of CAV1 knockout (KO) on functional plasticity and hypothesized th...

journal_title：Psychopharmacology

authors： Eisinger KRT,Chapp AD,Swanson SP,Tam D,Lopresti NM,Larson EB,Thomas MJ,Lanier LM,Mermelstein PG

更新日期：2020-09-01 00:00:00

abstract：:Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). H...

journal_title：Psychopharmacology

authors： Cross AJ,Misra A,Sandilands A,Taylor MJ,Green AR

更新日期：1993-01-01 00:00:00

abstract：:There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...

journal_title：Psychopharmacology

authors： File SE,Greenblatt DJ,Martin IL,Brown C

更新日期：1985-01-01 00:00:00

abstract：:Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...

journal_title：Psychopharmacology

authors： Yamamoto J

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...

journal_title：Psychopharmacology

authors： Lew R,Constantinescu CC,Holden D,Carson RE,Carroll V,Galluppi G,Koblan KS,Hopkins SC

更新日期：2020-11-01 00:00:00

abstract：:Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...

journal_title：Psychopharmacology

authors： Weingartner H,Rudorfer MV,Linnoila M

更新日期：1985-01-01 00:00:00

abstract：:Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity ...

journal_title：Psychopharmacology

authors： Kantak KM,Hegstrand LR,Eichelman B

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. OBJECTIVES:The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) r...

journal_title：Psychopharmacology

authors： McRae-Clark AL,Carter RE,Price KL,Baker NL,Thomas S,Saladin ME,Giarla K,Nicholas K,Brady KT

更新日期：2011-11-01 00:00:00

abstract：:A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...

journal_title：Psychopharmacology

authors： Sutton MA,Beninger RJ

更新日期：1999-05-01 00:00:00

abstract：:Intraperitoneal (IP) administration of the acetylcholinesterase inhibitor, soman (10-40 micrograms/kg), suppressed in a dose-related manner response rates in rats maintained under a multiple fixed-interval 50-s fixed-ratio 25 schedule of food delivery. Chronic administration of soman at weekly intervals resulted in to...

journal_title：Psychopharmacology

authors： Hymowitz N,Brezenoff HE,McGee J,Campbell K,Knight V

更新日期：1985-01-01 00:00:00

abstract：:The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...

journal_title：Psychopharmacology

authors： Jewett DC,Mosberg HI,Woods JH

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are gut derived hormones. GLP-1 and GLP-2 were shown to have pleiotropic effects in intestinal and pancreatic diseases. OBJECTIVE:We aimed to investigate the activities of GLP-1 and GLP-2 on nociception and inflammation in mice, involving th...

journal_title：Psychopharmacology

authors： Aykan DA,Kesim M,Ayan B,Kurt A

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：:It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...

journal_title：Psychopharmacology

authors： Welsch-Kunze S,Kuschinsky K

更新日期：1990-01-01 00:00:00

abstract：:Nicotine (0.16--0.50 mg/kg, SC) was found to exert a potent antinociceptive action on thermal stimuli as measured by the tail-flick test. This antinociceptive action of nicotine could be blocked by centrally active nicotinic or muscarinic blockers implicating both classes of cholinergic receptors in this effect. Quate...

journal_title：Psychopharmacology

authors： Sahley TL,Berntson GG

更新日期：1979-11-01 00:00:00

abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...

journal_title：Psychopharmacology

authors： Wu IT,Tang TH,Ko MC,Chiu CY,Lu KT

更新日期：2015-10-01 00:00:00

abstract：:Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...

journal_title：Psychopharmacology

authors： Tye NC,Horsman L,Wright FC,Pullar IA

更新日期：1979-05-15 00:00:00