Abstract:
:Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive symptoms was created with PCP. MAP caused a prolonged decrease in the cortical EEG power spectra, cocaine caused a marked decrease for a short time, and PCP produced no significant changes. In the hippocampal spectra, MAP induced a marked increase in the T2(6.0-7.9 Hz)/ T1(4.0-5.9 Hz) ratio, PCP caused a decrease of this ratio after an initial increase, and cocaine produced no significant change. (An increase in the T2/T1 ratio represents a shift of theta waves to higher frequencies.) Since apomorphine (a DA agonist) and MK-801 (an NMDA antagonist) caused the T2/T1 ratio to increase, positive schizophrenic symptoms caused by MAP may be related to the DA and NMDA systems. 3-PPP (a sigma agonist) caused biphasic changes similar to those induced by PCP. Haloperidol and chlorpromazine caused a decrease of the T2/T1 ratio. These results indicate that cortical and hippocampal EEG power spectra (especially the hippocampal T2/T1 ratio) can be used to characterize both qualitatively and quantitatively models of schizophrenia.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Yamamoto Jdoi
10.1007/s002130050306subject
Has Abstractpub_date
1997-06-01 00:00:00pages
379-87issue
4eissn
0033-3158issn
1432-2072journal_volume
131pub_type
杂志文章abstract::The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050536
更新日期:1998-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244368
更新日期:1991-01-01 00:00:00
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更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1978-04-14 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427352
更新日期:1979-06-28 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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更新日期:1983-01-01 00:00:00
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00429212
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179186
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-02-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-04-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2010-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244285
更新日期:1991-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2016-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00571418
更新日期:1978-01-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00