Abstract：
:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet young animals have been typically returned to the home cage immediately post-injection. To determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings, Sprague-Dawley rats were injected daily from P14 to P20 with 0, 5, 15, or 30 mg/kg cocaine HCl and placed for 30 min in either the experimental chamber or home cage. On P21 (test day), subjects were challenged with either 15 mg/kg cocaine or saline prior to placement in the experimental chamber. Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber, but not when these same doses were given in the home cage. Less consistent evidence for cocaine-induced sensitization was seen when examining locomotion, although trends for sensitization of this behavior were seen in animals chronically injected in either the test chamber or home cage. Thus, preweanlings can exhibit cocaine sensitization, particularly in terms of stereotypy, when tested shortly after the chronic exposure period, with expression of this sensitization being facilitated by pairing the chronic injections with the test context.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LPdoi
10.1007/s002130050653subject
Has Abstractpub_date
1998-07-01 00:00:00pages
114-23issue
2eissn
0033-3158issn
1432-2072journal_volume
138pub_type
杂志文章abstract：RATIONAL:Prefrontal cortex (PFC) and dorsal striatum are part of the neural circuit critical for executive attention. The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2581-0
更新日期：2012-01-01 00:00:00
abstract：RATIONALE:Preclinical evidence suggests that non-cannabinoid neurotransmitter systems are involved in the behavioral and physiological effects of cannabinoids, but relatively little research has been conducted in humans. OBJECTIVES:The aims of this study were to assess whether oral Delta(9)-tetrahydrocannabinol (Delta...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1393-3
更新日期：2009-04-01 00:00:00
abstract：:The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245133
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2322-4
更新日期：2011-11-01 00:00:00
abstract：:Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246018
更新日期：1996-06-01 00:00:00
abstract：:Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-015-3968-0
更新日期：2015-11-01 00:00:00
abstract：RATIONALE:Threatening social stimuli were used in this study as aversive conditions to test anxiety in lactating female mice. The odors of potential infanticidal males or the "stress odor" left by restrained mice represented two aversive conditions that have been suggested to modulate the time spent by the mothers to r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051120
更新日期：1999-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0346-y
更新日期：2006-05-01 00:00:00
abstract：:Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426773
更新日期：1977-10-20 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000637
更新日期：2001-03-01 00:00:00
abstract：:The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP injection of 1.8 g/kg ethanol was quantified after various intervals in separate groups of animals. Lower impairme...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244833
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How re...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4676-8
更新日期：2017-09-01 00:00:00
abstract：:The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246054
更新日期：1995-05-01 00:00:00
abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100686
更新日期：2001-04-01 00:00:00
abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1201-0
更新日期：2008-10-01 00:00:00
abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433021
更新日期：1983-01-01 00:00:00
abstract：:The daily fluid intake of male Wistar rats with simultaneous access to 6% ethanol and water was determined during a baseline period (1 week), following adrenalectomy (1 week) and for 3 weeks following SC implantation of hormone pellets containing corticosterone (CORT) or dexamethasone (DEX). Ethanol consumption droppe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245190
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-009-1533-4
更新日期：2009-08-01 00:00:00
abstract：RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-016-4324-8
更新日期：2016-07-01 00:00:00
abstract：:The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310526
更新日期：1986-01-01 00:00:00
abstract：:Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4906-8
更新日期：2018-07-01 00:00:00
abstract：RATIONALE:(+/-)-3,4-methylenedioxymethamphet-amine (MDMA; 'ecstasy'), a commonly used recreational drug, has typically been found to be related to poor cognitive function in humans. However, cannabis consumption may not have been adequately controlled for in these studies. OBJECTIVE:The present study was designed to f...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000591
更新日期：2001-01-01 00:00:00
abstract：:5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431969
更新日期：1980-02-01 00:00:00
abstract：RATIONALE:The amygdala and insular cortex are integral to the processing of emotionally salient stimuli. We have shown in healthy volunteers that an anxiolytic agent, lorazepam, dose-dependently attenuates activation of limbic structures. OBJECTIVE:The current study investigated whether administration of a selective s...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-007-1004-8
更新日期：2008-03-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1296-7
更新日期：2003-02-01 00:00:00
abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000630
更新日期：2001-03-01 00:00:00
abstract：:The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidanc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00176480
更新日期：1987-01-01 00:00:00
abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051029
更新日期：1999-07-01 00:00:00
abstract：RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-014-3467-8
更新日期：2014-08-01 00:00:00
abstract：RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1259-8
更新日期：2009-04-01 00:00:00
