Abstract:
:Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most frequently at shorter intervals after the last morphine injection; teeth chattering, wet dog shakes, ptosis, diarrhea, penile ejaculation, and hypothermia, at longer intervals. Others, including hostility, rhinnorhea and lacrimation did not change in frequency over the intervals measured. This order closely resembled that in which symptoms occurred as a result of withdrawal abstinence alone, though they were somewhat advanced in time. The results were discussed in relation to previously reported observations of naloxone-precipitated withdrawal, and in terms of their implications for a general theory of morphine withdrawal.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Linseman MAdoi
10.1007/BF00426773subject
Has Abstractpub_date
1977-10-20 00:00:00pages
159-64issue
2eissn
0033-3158issn
1432-2072journal_volume
54pub_type
杂志文章abstract::Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeuti...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00429689
更新日期:1979-05-25 00:00:00
abstract:RATIONALE:Cocaine addiction is a relapsing psychiatric disorder with a high prevalence in developed countries. To date, the reinstatement model has been difficult to implement in mice. The design of an appropriate reinstatement model in mice is required in order to use genetically modified animals with the aim of clari...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1184-x
更新日期:2008-09-01 00:00:00
abstract::Twenty-one (three groups of seven), men and women, 25-50 years of age were studied to determine whether or not rebound insomnia would increase the likelihood of self administering a benzodiazepine (triazolam 0.25 mg) hypnotic. The groups compared were patients with insomnia and disturbed sleep, insomnia and normal sle...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245259
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The positive modulation of gamma-aminobutyric acid type-A (GABAA) receptors is a putative mechanism via which alcohol escalates aggressive behavior. Broad-spectrum benzodiazepine antagonists block alcohol-heightened aggression in rats and monkeys. However, the degree to which GABAA subunit composition plays a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1661-1
更新日期:2004-03-01 00:00:00
abstract::In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05353-6
更新日期:2020-01-01 00:00:00
abstract::The effects of flumazenil, a benzodiazepine receptor antagonist, on triazolam- and zolpidem-induced memory impairment were investigated. Sixty subjects received oral triazolam 0.5 mg, zolpidem 20.0 mg, or placebo at 10 a.m. (n = 20 per drug). Ninety minutes later, half of the subjects (n = 10) in each oral drug group ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245635
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2168-8
更新日期:2005-07-01 00:00:00
abstract::In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle, pretreatment with the D1 DA antagonists, SCH 23390 (7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepin e) and A66359 (1- 2-bromo-4,5-dimethoxybenzyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 tetrahydroisoquinol...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246211
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A(2A) receptor stimulation exerts a functional antagonism at postsynaptic D(2) receptors. Data from animal models relevant to schizophrenia support a therapeutic effect of modulating adenosiner...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2315-3
更新日期:2011-11-01 00:00:00
abstract::Effects of chlordiazepoxide (CDP) and ethanolamine-O-sulphate (EOS) alone and in combination were tested on the acquisition and performance of continuous reinforcement - time out (CR-TO) and variable interval reinforcement - time out (VI-TO) operant discriminations in rats. CDP disrupted acquisition of CR-TO discrimin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310620
更新日期:1986-01-01 00:00:00
abstract::Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429014
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Alcohol and nicotine addiction are prevalent conditions that co-occur. Despite the prevalence of co-use, factors that influence the suppression and enhancement of concurrent alcohol and nicotine intake are largely unknown. OBJECTIVES:Our goals were to assess how nicotine abstinence and availability influence...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05426-6
更新日期:2020-04-01 00:00:00
abstract::The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02251292
更新日期:1993-01-01 00:00:00
abstract::The study compares the behavioral profiles induced in rats (N = 118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high do...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244813
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1027-0
更新日期:2002-05-01 00:00:00
abstract::Sixteen healthy volunteers were administered midazolam followed by placebo or the benzodiazepine antagonist, flumazenil, in a double-blind, cross-over study. Flumazenil reversed midazolam-induced sedation on the subjective, psychophysiological and motor indices used. In contrast, there was little evidence of any rever...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244252
更新日期:1991-01-01 00:00:00
abstract::The effect of the selective noradrenaline neurotoxin DSP4 on steady-state operant behaviour was examined using a quantitative behavioural paradigm based on Herrnstein's (1970) equation, which defines a hyperbolic relationship between steady-state response rate and reinforcement frequency in variable-interval schedules...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180039
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Impulsivity has been strongly linked to addictive behaviors, but can be operationalized in a number of ways that vary considerably in overlap, suggesting multidimensionality. OBJECTIVE:This study tested the hypothesis that the latent structure among multiple measures of impulsivity would reflect the followin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4372-0
更新日期:2016-09-01 00:00:00
abstract:RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1991-8
更新日期:2011-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5107-1
更新日期:2019-02-01 00:00:00
abstract::The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244300
更新日期:1991-01-01 00:00:00
abstract::A combined analysis of data from 11 controlled studies of loxapine versus either chlorpromazine or trifluoperazine in acute schizophrenia (5 studies) and chronic schizophrenia (6 studies) showed statistically significant superiority of loxapine on several items and factors of standardized psychiatric rating scales. Up...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431725
更新日期:1977-01-31 00:00:00
abstract:RATIONALE:Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs. OBJECTIVE:To compare the effects of carbamazepine, remacemide, and placebo on actual driving performance during a 12-day i...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100898
更新日期:2002-01-01 00:00:00
abstract:RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3829-2
更新日期:2015-06-01 00:00:00
abstract::Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00589905
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Repeated high doses of morphine in the rat cause stereotypic gnawing behavior that can be re-expressed by a low dose of morphine weeks and even months after the initial treatment. The determination of the role of serotonin in this sensitized morphine-induced behavior has both empirical and theoretical relevan...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051083
更新日期:1999-09-01 00:00:00
abstract:RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1259-8
更新日期:2009-04-01 00:00:00
abstract:RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3161-2
更新日期:2013-12-01 00:00:00
abstract:RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05418-6
更新日期:2020-03-01 00:00:00
abstract::Rats may produce ultrasonic vocalizations (USV) in threatening situations. USV of adult male rats in association with aversive stimulation was evaluated as a screening method for anxiolytic drugs. The triazolobenzodiazepine alprazolam, the 5-HT uptake inhibitors fluvoxamine and clomipramine, the mixed 5-HT/NA uptake i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245095
更新日期:1995-01-01 00:00:00