A reliable method to study cue-, priming-, and stress-induced reinstatement of cocaine self-administration in mice.

abstract：:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...

journal_title：Psychopharmacology

authors： Broadbent J,Grahame NJ,Cunningham CL

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...

journal_title：Psychopharmacology

authors： Childs E,Shoaib M,Stolerman IP

更新日期：2006-06-01 00:00:00

abstract：:Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only...

journal_title：Psychopharmacology

authors： Hienz RD,Spear DJ,Pyle DA,Brady JV

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:A previous study found that a 10-min bout of moderate intensity exercise reduced cigarette withdrawal symptoms and desire to smoke in sedentary smokers but the effect may have been due to participants focusing attention on physical activity rather than the activity itself. OBJECTIVES:This study examined the ...

journal_title：Psychopharmacology

authors： Daniel J,Cropley M,Ussher M,West R

更新日期：2004-07-01 00:00:00

abstract：RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...

journal_title：Psychopharmacology

authors： Cepeda-Benito A,Tiffany ST,Cox LS

更新日期：1999-08-01 00:00:00

abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...

journal_title：Psychopharmacology

authors： Corona GL,Cucchi ML,Frattini P,Santagostino G,Schinelli S,Zerbi F,Savoldi F

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...

journal_title：Psychopharmacology

authors： Zhang Y,Liang Y,Levran O,Randesi M,Yuferov V,Zhao C,Kreek MJ

更新日期：2017-08-01 00:00:00

abstract：RATIONALE:Catecholamine transmission modulates numerous cognitive and reward-related processes that can subserve more complex functions such as cost/benefit decision making. Dopamine has been shown to play an integral role in decisions involving reward uncertainty, yet there is a paucity of research investigating the c...

journal_title：Psychopharmacology

authors： Montes DR,Stopper CM,Floresco SB

更新日期：2015-08-01 00:00:00

abstract：RATIONALE/OBJECTIVES:Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies. Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system ha...

journal_title：Psychopharmacology

authors： Domschke K,Klauke B,Winter B,Gajewska A,Herrmann MJ,Warrings B,Mühlberger A,Wosnitza K,Dlugos A,Naunin S,Nienhaus K,Fobker M,Jacob C,Arolt V,Pauli P,Reif A,Zwanzger P,Deckert J

更新日期：2012-08-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...

journal_title：Psychopharmacology

authors： Lê AD,Khanna JM,Kalant H,LeBlanc AE

更新日期：1980-02-01 00:00:00

abstract：:Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...

journal_title：Psychopharmacology

authors： Rothenberg SJ,Selkoe D

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of dr...

journal_title：Psychopharmacology

authors： Bell SM,Reynolds JG,Thiele TE,Gan J,Figlewicz DP,Woods SC

更新日期：1998-09-01 00:00:00

abstract：:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...

journal_title：Psychopharmacology

authors： Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman ME

更新日期：1994-04-01 00:00:00

abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

journal_title：Psychopharmacology

authors： Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：:Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...

journal_title：Psychopharmacology

authors： Pettit HO,Mueller K

更新日期：1989-01-01 00:00:00

abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...

journal_title：Psychopharmacology

authors： Blander A,Hunt T,Blair R,Amit Z

更新日期：1984-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...

journal_title：Psychopharmacology

authors： Tani Y,Saito K,Tsuneyoshi A,Imoto M,Ohno T

更新日期：1997-02-01 00:00:00

abstract：:Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...

journal_title：Psychopharmacology

authors： Rumbold GR,White JM

更新日期：1987-01-01 00:00:00

abstract：:Previous work in this and another laboratory has shown that nicotine tablets improve the performance of a rapid information processing task and reduce the Stroop effect, whereas scopolamine has the opposite effects. The purpose of this study was to extend these previous findings by determining whether, when administer...

journal_title：Psychopharmacology

authors： Wesnes K,Revell A

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Greater incidence of anxiety and depressive disorders of women compared to men may be due in part to progesterone (P) and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acting in limbic regions, such as the amygdala. OBJECTIVE:If P's metabolism via 5alpha-reduction to 3alpha...

journal_title：Psychopharmacology

authors： Walf AA,Sumida K,Frye CA

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...

journal_title：Psychopharmacology

authors： Thiel KJ,Sanabria F,Neisewander JL

更新日期：2009-06-01 00:00:00

abstract：:Ro 15-4513, a partial inverse agonist at the benzodiazepine (BZ) receptor site was labelled with 11C and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (PET) on Cynomolgus monkeys. The total radiochemical yield of [11C]Ro 15-4513 was 30-40% with an overall sy...

journal_title：Psychopharmacology

authors： Halldin C,Farde L,Litton JE,Hall H,Sedvall G

更新日期：1992-01-01 00:00:00

abstract：:Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...

journal_title：Psychopharmacology

authors： Millan MJ,Girardon S,Dekeyne A

更新日期：1999-03-01 00:00:00

abstract：RATIONALE:Recent research highlights the need to extend our understanding of how exercise may aid smoking cessation, through exploration of different modes, intensity and duration of exercise. OBJECTIVES:The purpose of the study was to examine the effects of a 1-mile self-paced walk on different measures of urges to s...

journal_title：Psychopharmacology

authors： Taylor AH,Katomeri M,Ussher M

更新日期：2005-08-01 00:00:00

abstract：RATIONALE:Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the fo...

journal_title：Psychopharmacology

authors： Estrada-Camarena E,Rivera NM,Berlanga C,Fernández-Guasti A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:The behavioral effects of racemic zopiclone are similar to those of benzodiazepines that positively modulate GABA at the GABA(A) receptor complex; however, it is not clear how enantiomers or metabolites of zopiclone contribute to the benzodiazepine-like behavioral effects of racemic zopiclone. OBJECTIVES:Rac...

journal_title：Psychopharmacology

authors： McMahon LR,Jerussi TP,France CP

更新日期：2003-01-01 00:00:00

abstract：:These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue pro...

journal_title：Psychopharmacology

authors： Salamone JD,Johnson CJ,McCullough LD,Steinpreis RE

更新日期：1990-01-01 00:00:00

abstract：:The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P les...

journal_title：Psychopharmacology

authors： Hawkins R,Kripke DF,Janowsky DS

更新日期：1978-01-31 00:00:00