Abstract：
:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-h intervals), and 1 h after pretreatment with saline, 0.10 or 0.15 mg/kg haloperidol. During a subsequent test, mice showed locomotor sensitization despite blockade of ethanol stimulated activity by haloperidol on the first conditioning trial. Moreover, test session activity was reduced in subjects that had previously received haloperidol, even though haloperidol was not present during testing. The second experiment examined the nature of the latter finding by comparing subjects that received equal exposure to haloperidol but differed in the pairing of its administration with the activity chambers. After four conditioning trials, each group was tested in the absence of haloperidol. Mice that had previously received haloperidol paired with the activity chambers were less active than control groups, suggesting development of a conditioned suppression of activity. Overall, these results suggest a dissociation of the neurobiological mechanisms that mediate the acute locomotor stimulant effects of ethanol and those mediating sensitization. Further, these studies illustrate the importance of antagonist-alone control groups that assess the possible influence of associative learning induced by the antagonist itself.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Broadbent J,Grahame NJ,Cunningham CLdoi
10.1007/BF02245821subject
Has Abstractpub_date
1995-08-01 00:00:00pages
475-82issue
4eissn
0033-3158issn
1432-2072journal_volume
120pub_type
杂志文章abstract：:Pigs trained to avoid shocks by crossing a barrier in a shuttle-box according to a continuous avoidance procedure were submitted to a Pavlovian discriminative fear-conditioning procedure in which a tone was always followed by unavoidable shock (CS+) and another tone never followed by shock (CS-). The presentation of t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427473
更新日期：1976-08-26 00:00:00
abstract：:Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02316862
更新日期：1991-01-01 00:00:00
abstract：:The predatory behavior of ferrets (Putorius putorius furo L.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. For the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. Killing success decreases with a relat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427754
更新日期：1978-10-31 00:00:00
abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433261
更新日期：1980-01-01 00:00:00
abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174701
更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00422406
更新日期：1981-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00427446
更新日期：1984-01-01 00:00:00
abstract：:Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245247
更新日期：1995-03-01 00:00:00
abstract：RATIONALE:Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state dependency. OBJECTIVES:The current study investig...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2215-6
更新日期：2011-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000508
更新日期：2000-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-1063-x
更新日期：2008-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1758-6
更新日期：2004-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02251292
更新日期：1993-01-01 00:00:00
abstract：:Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174684
更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000477
更新日期：2000-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1093-3
更新日期：2002-07-01 00:00:00
abstract：RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0377-4
更新日期：2006-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050428
更新日期：1997-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2015-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245428
更新日期：1992-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1154-3
更新日期：2008-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-012-2684-2
更新日期：2012-09-01 00:00:00
abstract：:In the present pilot study, an attempt was made to shape and maintain cigarette smoking behavior in rhesus monkeys both with and without the simultaneous use of other reinforcers. Initially, 14 monkeys were trained to suck air and puff on cigarettes using sweetened liquid reinforcer. After smoking had been established...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431644
更新日期：1981-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0637-3
更新日期：2007-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05207-1
更新日期：2019-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1337-2
更新日期：2003-07-01 00:00:00
abstract：RATIONALE:Microinjections of ethanol and acetaldehyde into ventral tegmental area (VTA) produce locomotor activation in rats through mechanisms dependent on the mu-opioid receptors. However, it is not clear how these drugs can interact with these receptors. It has been hypothesized that salsolinol could be the responsi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1751-9
更新日期：2010-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244602
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Synthetic psychostimulant abuse, including cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV), continues to increase in many countries. Similar to cocaine but with greater potency, MDPV elicits a transient sympathomimetic response by blocking cellular uptake of dopamine (DA) and norepinephrine (NE)-admin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4709-3
更新日期：2017-11-01 00:00:00
abstract：:We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050409
更新日期：1997-10-01 00:00:00
