Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man.

abstract：RATIONALE:Schizophrenia is characterized by a large variety of cognitive symptoms, among which information processing deficits have been extensively studied. So far, these aspects have been found to be remarkably stable and effective treatment is still lacking. Traditionally, information processing is subdivided into p...

journal_title：Psychopharmacology

authors： Ellenbroek BA

更新日期：2004-06-01 00:00:00

abstract：:In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...

journal_title：Psychopharmacology

authors： Pedersen OL,Kragh-Sørensen P,Bjerre M,Overø KF,Gram LF

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...

journal_title：Psychopharmacology

authors： Frye CA,Rhodes ME,Raol YH,Brooks-Kayal AR

更新日期：2006-06-01 00:00:00

abstract：:2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...

journal_title：Psychopharmacology

authors： Birmingham AM,Nader SH,Grant KA,Davies HM,Nader MA

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...

journal_title：Psychopharmacology

authors： Hearn AJ,Gallagher P,Owen BM,Smith MS,Watson S,Young AH

更新日期：2004-02-01 00:00:00

abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1977-03-16 00:00:00

abstract：RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...

journal_title：Psychopharmacology

authors： Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid N

更新日期：2011-09-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...

journal_title：Psychopharmacology

authors： Nakamura A,Narita M,Miyoshi K,Shindo K,Okutsu D,Suzuki M,Higashiyama K,Suzuki T

更新日期：2008-10-01 00:00:00

abstract：RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...

journal_title：Psychopharmacology

authors： Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

journal_title：Psychopharmacology

authors： Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...

journal_title：Psychopharmacology

authors： Olivier JD,Jans LA,Korte-Bouws GA,Korte SM,Deen PM,Cools AR,Ellenbroek BA,Blokland A

更新日期：2008-10-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson's disease (PD). These paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the baseline dopamine l...

journal_title：Psychopharmacology

authors： Vo A,Seergobin KN,Morrow SA,MacDonald PA

更新日期：2016-07-01 00:00:00

abstract：:Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...

journal_title：Psychopharmacology

authors： Krystal JH,Webb E,Grillon C,Cooney N,Casal L,Morgan CA 3rd,Southwick SM,Davis M,Charney DS

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Cortical gamma-aminobutyric acid (GABA)ergic neurons contribute to the orchestration of pyramidal neuron population firing as follows: (1) by releasing GABA on GABA(A) and GABA(B) receptors, (2) by releasing reelin in the proximity of integrin receptors located on cortical pyramidal neuron dendritic spines, a...

journal_title：Psychopharmacology

authors： Guidotti A,Auta J,Davis JM,Dong E,Grayson DR,Veldic M,Zhang X,Costa E

更新日期：2005-07-01 00:00:00

abstract：:This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the...

journal_title：Psychopharmacology

authors： Harvey JA,Welsh SE,Hood H,Romano AG

更新日期：1999-01-01 00:00:00

abstract：:Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with alpha-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training. CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pret...

journal_title：Psychopharmacology

authors： Sansone M,Renzi P

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...

journal_title：Psychopharmacology

authors： Bressan RA,Erlandsson K,Spencer EP,Ell PJ,Pilowsky LS

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...

journal_title：Psychopharmacology

authors： Suhara T,Okauchi T,Sudo Y,Takano A,Kawabe K,Maeda J,Kapur S

更新日期：2002-02-01 00:00:00

abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...

journal_title：Psychopharmacology

authors： Robinson OJ,Sahakian BJ

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...

journal_title：Psychopharmacology

authors： Cui X,Lefevre E,Turner KM,Coelho CM,Alexander S,Burne TH,Eyles DW

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

journal_title：Psychopharmacology

authors： Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...

journal_title：Psychopharmacology

authors： Cervo L,Cocco A,Carnovali F

更新日期：2004-04-01 00:00:00

abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...

journal_title：Psychopharmacology

authors： Stiles MF,Campbell LR,Graff DW,Jones BA,Fant RV,Henningfield JE

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:Batteries of tests that are thought to measure different aspects of anxiety-related behaviour are used to characterise mice after genetic or pharmacological manipulation. However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time,...

journal_title：Psychopharmacology

authors： Fraser LM,Brown RE,Hussin A,Fontana M,Whittaker A,O'Leary TP,Lederle L,Holmes A,Ramos A

更新日期：2010-07-01 00:00:00

abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

journal_title：Psychopharmacology

authors： Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...

journal_title：Psychopharmacology

authors： Gunes A,Scordo MG,Jaanson P,Dahl ML

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals. Pharmacologic inhibition leads to a delay of the oscillations with the magnitude of this effect dep...

journal_title：Psychopharmacology

authors： Sprouse J,Reynolds L,Kleiman R,Tate B,Swanson TA,Pickard GE

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00