Pre-attentive processing and schizophrenia: animal studies.

abstract：RATIONALE:Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. OBJECTIVES:The pre...

journal_title：Psychopharmacology

authors： Swalve N,Smethells JR,Carroll ME

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Attentional bias for alcohol-related cues is associated with the motivation to drink alcohol, possibly because attentional bias increases craving. OBJECTIVES:We examined whether an experimentally induced attentional bias would influence subjective and behavioural indices of the motivation to drink. METHODS:...

journal_title：Psychopharmacology

authors： Field M,Eastwood B

更新日期：2005-12-01 00:00:00

abstract：:Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...

journal_title：Psychopharmacology

authors： Willner P,McGuirk J,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...

journal_title：Psychopharmacology

authors： Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid...

journal_title：Psychopharmacology

authors： Lafleur DL,Pittenger C,Kelmendi B,Gardner T,Wasylink S,Malison RT,Sanacora G,Krystal JH,Coric V

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...

journal_title：Psychopharmacology

authors： Russig H,Murphy CA,Feldon J

更新日期：2003-09-01 00:00:00

abstract：:Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...

journal_title：Psychopharmacology

authors： Blozovski D,Hennocq N

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...

journal_title：Psychopharmacology

authors： Olivier JD,Jans LA,Korte-Bouws GA,Korte SM,Deen PM,Cools AR,Ellenbroek BA,Blokland A

更新日期：2008-10-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...

journal_title：Psychopharmacology

authors： Yang F,Wang K,Du X,Deng H,Wu HE,Yin G,Ning Y,Huang X,Teixeira AL,de Quevedo J,Soares JC,Li X,Lang X,Zhang XY

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. OBJECTIVES:To revie...

journal_title：Psychopharmacology

authors： Vitiello B

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...

journal_title：Psychopharmacology

authors： Flood DG,Zuvich E,Marino MJ,Gasior M

更新日期：2011-06-01 00:00:00

abstract：:Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each do...

journal_title：Psychopharmacology

authors： Turkkan JS,Hienz RD

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Animal models aimed to mimic mania have in common the lack of genuine affective parameters. Although rodent amphetamine-induced hyperlocomotion is a frequently used behavioral model of mania, locomotor activity is a rather unspecific target for developing new pharmacological therapies, and does not necessaril...

journal_title：Psychopharmacology

authors： Pereira M,Andreatini R,Schwarting RK,Brenes JC

更新日期：2014-07-01 00:00:00

abstract：:The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the t...

journal_title：Psychopharmacology

authors： Eschalier A,Aumaître O,Decamps A,Dordain G

更新日期：1983-01-01 00:00:00

abstract：:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...

journal_title：Psychopharmacology

authors： Myers RD,Swartzwelder HS,Dyer RS

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...

journal_title：Psychopharmacology

authors： Halberstadt AL,Brandt SD,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：RATIONALE:The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endogenous GABAergic neuroactive steroid levels and beh...

journal_title：Psychopharmacology

authors： Snelling C,Tanchuck-Nipper MA,Ford MM,Jensen JP,Cozzoli DK,Ramaker MJ,Helms M,Crabbe JC,Rossi DJ,Finn DA

更新日期：2014-09-01 00:00:00

abstract：:The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...

journal_title：Psychopharmacology

authors： Marder SR,Hubbard JW,Van Putten T,Midha KK

更新日期：1989-01-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：:Rats exhibit profound individual differences in their propensity to ingest sugar and in their locomotor response to AMP. Intrinsic variation in the responsiveness of mesolimbic dopamine mechanisms has been suggested to account for these individual differences. In light of this overlap, it might be expected that indivi...

journal_title：Psychopharmacology

authors： Sills TL,Vaccarino FJ

更新日期：1994-09-01 00:00:00

abstract：RATIONALE:Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of ...

journal_title：Psychopharmacology

authors： Fattore L,Piva A,Zanda MT,Fumagalli G,Chiamulera C

更新日期：2018-02-01 00:00:00

abstract：:Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...

journal_title：Psychopharmacology

authors： Bourson A,Moser PC

更新日期：1990-01-01 00:00:00

abstract：AIM:Excess consumption of alcohol leads to impaired cognition and decision making; hence, alcohol-containing products and advertising contain warning messages about the adverse effects of excess drinking. However, there is a need to understand how alcohol influences the processing of advisory messages. METHOD:The curr...

journal_title：Psychopharmacology

authors： Phillips JG,Ogeil RP

更新日期：2010-03-01 00:00:00

abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

journal_title：Psychopharmacology

authors： Cardoso C,Ellenbogen MA,Linnen AM

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:Preclinical evidence suggests that non-cannabinoid neurotransmitter systems are involved in the behavioral and physiological effects of cannabinoids, but relatively little research has been conducted in humans. OBJECTIVES:The aims of this study were to assess whether oral Delta(9)-tetrahydrocannabinol (Delta...

journal_title：Psychopharmacology

authors： Lile JA,Kelly TH,Pinsky DJ,Hays LR

更新日期：2009-04-01 00:00:00

abstract：:There is little evidence concerning the effects of caffeine in doses typical of one cup of tea. The present study investigated the effect of 60 mg caffeine, consumed in either tea or hot water, on performance on a subset of the CANTAB test battery. Eight males participated in a practice session and four test sessions....

journal_title：Psychopharmacology

authors： Durlach PJ

更新日期：1998-11-01 00:00:00

abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...

journal_title：Psychopharmacology

authors： Malison RT,McCance E,Carpenter LL,Baldwin RM,Seibyl JP,Price LH,Kosten TR,Innis RB

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...

journal_title：Psychopharmacology

authors： Tracy ME,Banks ML,Shelton KL

更新日期：2016-02-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00

abstract：:The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...

journal_title：Psychopharmacology

authors： Johnson PL,Stellar JR

更新日期：1994-05-01 00:00:00