Abstract:
RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be one mechanism by which oxytocin promotes prosocial behavior. METHOD:In a between-subject, randomized, and double-blind experiment, 100 university students received a 24 I.U. dose of intranasal oxytocin or placebo, and then completed the Revised NEO Personality Inventory (NEO-PI-R) and other self-report measures 90 min later. RESULTS:Intranasal oxytocin increased ratings of NEO-PI-R extraversion and openness to experiences [F(1,98) = 4.910, p = .025, partial η (2) = .05; F(1,98) = 6.021, p = .016, partial η (2) = .06], particularly for the following facets: positive emotions (d = 0.48, p < .05), warmth (d = 0.47, p < .05), openness to values (d = 0.45, p < .05) and ideas (d = 0.40, p < .05), trust (d = 0.44, p < .05), and altruism (d = 0.40, p < .05). Oxytocin had no influence on ratings of negative emotionality, conscientiousness, rejection sensitivity, depression, worry, self-esteem, and perceived social support. CONCLUSION:The administration of oxytocin improved participants' self-perceptions of their personality, at least for certain traits important for social affiliation. Increased positive self-referential processing may be one mechanism by which oxytocin promotes positive social behaviors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cardoso C,Ellenbogen MA,Linnen AMdoi
10.1007/s00213-011-2527-6subject
Has Abstractpub_date
2012-04-01 00:00:00pages
741-9issue
4eissn
0033-3158issn
1432-2072journal_volume
220pub_type
杂志文章,随机对照试验abstract::An experiment was conducted to test whether centrally acting drugs could act as conditioned stimuli (CS) in a classical conditioning paradigm in which electric shock acted as the unconditioned stimulus (US) and suppression of drinking was used as an indicator of a conditioned response (CR). Thirsty rats were allowed t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244921
更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245478
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abstract::Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,已发布勘误
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050992
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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abstract:RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2014-12-01 00:00:00
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更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased ...
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更新日期:2014-08-01 00:00:00