Abstract:
RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacquisition of oxycodone seeking. METHODS:One hundred thirty-two male Sprague-Dawley rats underwent place conditioning with oxycodone (2 mg/kg, SC; ×6 days), extinction (vehicle × 6 days), and reconditioning with 0, 0.25, 2, or 5 mg/kg oxycodone (2 days). Yohimbine (0, 2.5, or 5 mg/kg, IP) was administered 30 min prior to reconditioning. RESULTS:Pretreatment with 2.5 mg/kg yohimbine increased, while 5 mg/kg yohimbine decreased, reacquisition of oxycodone-induced place preference. A follow-up study (n = 30) further indicated that the effect of yohimbine was specific to reacquisition. CONCLUSION:The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Campbell AT,Kwiatkowski D,Boughner E,Leri Fdoi
10.1007/s00213-012-2640-1subject
Has Abstractpub_date
2012-07-01 00:00:00pages
247-55issue
2eissn
0033-3158issn
1432-2072journal_volume
222pub_type
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更新日期:2005-05-01 00:00:00
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