Abstract:
:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval, retrieval latency, inter-retrieval interval, number of pup retrieved and number of corners to which they were retrieved, time nest building, number of paper strips used, nursing time, time in motion, and number of squares entered. Disruption was dose-dependent for all the preceding except number of corners and time nest building. Amphetamine had no effect on the rate of maternal locomotion. The impact of amphetamine on nursing was significantly greater at pup ages of 3-4 days than at 10-11 days. Drug-induced augmentation of arousal exceeding optimal levels for adequate care-giving and locomotor stimulation incompatible with elements of maternal behavior may account for dose-dependent impairment in the range of 0.25 to 1.50 mg/kg d-amphetamine.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BAdoi
10.1007/BF00435314subject
Has Abstractpub_date
1980-01-01 00:00:00pages
195-9issue
2eissn
0033-3158issn
1432-2072journal_volume
70pub_type
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更新日期:1977-03-23 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-01-01 00:00:00
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更新日期:1979-10-01 00:00:00
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更新日期:1988-01-01 00:00:00
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更新日期:2008-05-01 00:00:00
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更新日期:1979-03-22 00:00:00
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journal_title:Psychopharmacology
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更新日期:2009-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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更新日期:2009-08-01 00:00:00