Savoxepine fails to selectively influence glucose metabolism in the rat limbic system.

abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...

journal_title：Psychopharmacology

authors： Yisak W,Farde L,von Bahr C,Nilsson LB,Fredriksson G,Ogenstad S

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Selective attention deficit, characterised by the inability to differentiate relevant from irrelevant information, is considered to underlie many cognitive deficits of schizophrenia, and appears to be only marginally responsive to treatment with current antipsychotics. OBJECTIVES:We compared the activity of ...

journal_title：Psychopharmacology

authors： Terranova JP,Chabot C,Barnouin MC,Perrault G,Depoortere R,Griebel G,Scatton B

更新日期：2005-08-01 00:00:00

abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...

journal_title：Psychopharmacology

authors： Meller E

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the fo...

journal_title：Psychopharmacology

authors： Estrada-Camarena E,Rivera NM,Berlanga C,Fernández-Guasti A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...

journal_title：Psychopharmacology

authors： Fisk JE,Montgomery C,Wareing M,Murphy PN

更新日期：2005-09-01 00:00:00

abstract：:Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...

journal_title：Psychopharmacology

authors： Syme GJ,Syme LA

更新日期：1979-03-22 00:00:00

abstract：:Changes in smooth pursuit eye tracking of targets moving sinusoidally in horizontal and vertical planes before and after up to 10 mg oral methadone were measured electrooculographically in nontolerant nondependent humans. Methadone depressed the gain of horizontal tracking movements at most frequencies tested (0.2 - 1...

journal_title：Psychopharmacology

authors： Rothenberg S,Schottenfeld S,Selkoe D,Gross K

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...

journal_title：Psychopharmacology

authors： Hajek P,Przulj D,Phillips A,Anderson R,McRobbie H

更新日期：2017-03-01 00:00:00

abstract：:The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedul...

journal_title：Psychopharmacology

authors： Carroll ME,Lac ST

更新日期：1998-05-01 00:00:00

abstract：:Two methods were used to assess nicotine-induced antinociception: tail withdrawal from a hot water bath and hind paw withdrawal from a hotplate. Nicotine doses which produced 75-80% maximum response were 0.75 mg/kg (free base) for tail withdrawal and 0.35 mg/kg for paw withdrawal. The peripheral blocker chlorisondamin...

journal_title：Psychopharmacology

authors： Caggiula AR,Epstein LH,Perkins KA,Saylor S

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...

journal_title：Psychopharmacology

authors： Bressan RA,Erlandsson K,Spencer EP,Ell PJ,Pilowsky LS

更新日期：2004-09-01 00:00:00

abstract：:The tricyclic anticonvulsant carbamazepine (CBZ) is effective in pain and affective disorder, but the mechanism of action for this drug has not been defined. Recently it was reported that CBZ had interaction with adenosine receptor, which is related to the inhibition of release of neurotransmitter. In the present stud...

journal_title：Psychopharmacology

authors： Fujiwara Y,Sato M,Otsuki S

更新日期：1986-01-01 00:00:00

abstract：:Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine. This disruption is reversed by DA antagonists, leading to proposals that this approach may be a useful means to ident...

journal_title：Psychopharmacology

authors： Varty GB,Higgins GA

更新日期：1995-11-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...

journal_title：Psychopharmacology

authors： Foltin RW,Fischman MW,Byrne MF

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...

journal_title：Psychopharmacology

authors： Duxon MS,Stretton J,Starr K,Jones DN,Holland V,Riley G,Jerman J,Brough S,Smart D,Johns A,Chan W,Porter RA,Upton N

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...

journal_title：Psychopharmacology

authors： Le Merrer J,Faget L,Matifas A,Kieffer BL

更新日期：2012-09-01 00:00:00

abstract：:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...

journal_title：Psychopharmacology

authors： Sargent P,Williamson DJ,Pearson G,Odontiadis J,Cowen PJ

更新日期：1997-08-01 00:00:00

abstract：:Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four...

journal_title：Psychopharmacology

authors： Levin ED,Gunne LM

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...

journal_title：Psychopharmacology

authors： Dvorkin A,Culver KE,Szechtman H

更新日期：2006-07-01 00:00:00

abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...

journal_title：Psychopharmacology

authors： Broadbear JH,Winger G,Rice KC,Woods JH

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...

journal_title：Psychopharmacology

authors： Flood DG,Zuvich E,Marino MJ,Gasior M

更新日期：2011-06-01 00:00:00

abstract：:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...

journal_title：Psychopharmacology

authors： Strain EC,Stitzer ML,Liebson IA,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...

journal_title：Psychopharmacology

authors： Ferland CL,Reichel CM,McGinty JF

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Impulsive behaviour is a component of psychiatric disorders such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), or personality disorders. Most experimental studies on impulsive behaviour punish impulsive choices by loss or delay of reward. In the present study, impulsive behaviour was p...

journal_title：Psychopharmacology

authors： Evenden J,Ko T

更新日期：2005-07-01 00:00:00

abstract：:The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...

journal_title：Psychopharmacology

authors： Serra G,Collu M,Gessa GL

更新日期：1987-01-01 00:00:00

abstract：:The effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )IPS) has been studied in adolescent baboons, Papio papio, from Senegal. Ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the EEG, and abolished myoclonic response...

journal_title：Psychopharmacology

authors： Anlezark G,Meldrum B

更新日期：1978-04-14 00:00:00

abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...

journal_title：Psychopharmacology

authors： Mumenthaler MS,Taylor JL,O'Hara R,Yesavage JA

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Environmental stimuli associated with drugs of abuse are believed to play a major role in the motivation to take drugs, drug dependence, and relapse. Previous work from this laboratory demonstrated that the response-contingent presentation of drug-related, visual cues was at least as important as nicotine in ...

journal_title：Psychopharmacology

authors： Caggiula AR,Donny EC,White AR,Chaudhri N,Booth S,Gharib MA,Hoffman A,Perkins KA,Sved AF

更新日期：2002-09-01 00:00:00

abstract：RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...

journal_title：Psychopharmacology

authors： Porter RJ,Gallagher P,Watson S,Smith MS,Young AH

更新日期：2003-08-01 00:00:00