Abstract：
:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the second "consumption component" during which each response produced a 1-g food pellet. After a 10-min interval in which no response occurred, the consumption component was terminated. The effects of diazepam (DZP: 0.12-4.0 mg/kg) were determined by having the baboons drink a dose on Tuesdays and Fridays 45-60 min before the daily session. DZP produced dose-dependent increases in food intake in three of the four baboons. DZP increased the size of the first two meals and total duration of eating, but had no effect on eating rate or the number of meals within a session. The effect of DZP on the topography of feeding of baboons differs from previous reports on the effects of benzodiazepines on the topography of feeding in rodents. This suggests that species or procedural differences influence the effects of DZP on food intake.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Foltin RW,Fischman MW,Byrne MFdoi
10.1007/BF00439545subject
Has Abstractpub_date
1989-01-01 00:00:00pages
443-7issue
4eissn
0033-3158issn
1432-2072journal_volume
97pub_type
杂志文章abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a potent and selective serotonin neurotoxin whose use is growing among adolescents. Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence. OBJ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1679-4
更新日期：2004-05-01 00:00:00
abstract：RATIONALE:Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is ev...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
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更新日期：2000-05-01 00:00:00
abstract：:The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442252
更新日期：1989-01-01 00:00:00
abstract：:These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442007
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05758-8
更新日期：2021-01-29 00:00:00
abstract：RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0364-9
更新日期：2006-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00634456
更新日期：1989-01-01 00:00:00
abstract：:In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426661
更新日期：1979-02-28 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431969
更新日期：1980-02-01 00:00:00
abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
abstract：RATIONALE:Alzheimer's disease (AD) is characterized by memory loss and synaptic damage. Previous studies suggested that xanthoceraside decreases glutamate-induced PC12 cell death, ameliorates memory deficits, and increases the number of dendritic spines in AD mice. These results indicated that xanthoceraside might have...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4775-6
更新日期：2018-01-01 00:00:00
abstract：RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1583-y
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:The comparative effects of a newly described specific alpha7 nAChR partial agonist, S 24795, and a cholinesterase inhibitor, donepezil, currently used as a symptomatic Alzheimer's disease treatment were studied in two mouse models of aging-related memory deficits. MATERIALS AND METHODS:We employed radial ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-1063-x
更新日期：2008-04-01 00:00:00
abstract：:Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050811
更新日期：1999-01-01 00:00:00
abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-011-2341-1
更新日期：2011-11-01 00:00:00
abstract：:It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00464579
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100892
更新日期：2002-01-01 00:00:00
abstract：RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-013-3199-1
更新日期：2013-11-01 00:00:00
abstract：:The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174371
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Caffeine is commonly believed to offset the acute effects of alcohol, but some evidence suggests that cognitive processes remain impaired when caffeine and alcohol are coadministered. OBJECTIVES:No previous study has investigated the separate and joint effects of alcohol and caffeine on conflict monitoring a...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4208-y
更新日期：2016-04-01 00:00:00
abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050877
更新日期：1999-02-01 00:00:00
abstract：RATIONALE:Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function. OBJECTIVE:The aim of this study was to investigate these alterations during a perturbed homeostatic state. METHODS:Fifteen patients with schizophrenia and 13...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1890-y
更新日期：2004-11-01 00:00:00
abstract：RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1918-3
更新日期：2004-12-01 00:00:00
abstract：RATIONALE:Caffeine is present in many widely consumed drinks and some foods. In the fairly extensive literature on the psychostimulant effects of caffeine, there are few dose-response studies and even fewer studies of the effects of doses of caffeine lower than 50 mg (the range of the amounts of caffeine contained in, ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000506
更新日期：2000-10-01 00:00:00
abstract：:The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172869
更新日期：1986-01-01 00:00:00
abstract：INTRODUCTION:Genetic causes, or predisposition, are increasingly accepted to be part of the ethiopathogenesis of many neuropsychiatric diseases. While genes can be studied in any type of cells, their physiological function in human brain cells is difficult to evaluate, particularly in living subjects. METHODS:As a fir...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3384-2
更新日期：2014-03-01 00:00:00
abstract：:Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments. Measures of palmar sweating and subjective anxiety showed that anticipation of speaking in public increased anxiety relative to baseline and prestress conditions, a...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00436092
更新日期：1982-01-01 00:00:00
abstract：:Ro 15-4513, a partial inverse agonist at the benzodiazepine (BZ) receptor site was labelled with 11C and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (PET) on Cynomolgus monkeys. The total radiochemical yield of [11C]Ro 15-4513 was 30-40% with an overall sy...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245279
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05706-6
更新日期：2021-02-01 00:00:00
abstract：:Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine. This disruption is reversed by DA antagonists, leading to proposals that this approach may be a useful means to ident...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246437
更新日期：1995-11-01 00:00:00
