Abstract：
:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was completely blocked by the selective dopamine D2 receptor antagonist, pimozide (0.5 mg/kg) but not by selective dopamine D1 receptor antagonist, SCH 23390 (0.5 and 1 mg/kg). Unlike olanzapine, the selective dopamine D2 receptor antagonists such as haloperidol (0.25 and 0.5 mg/kg) and pimozide (0.5 and 1 mg/kg), the selective 5-HT2A receptor antagonist, ritanserin (0.5 and 1 mg/kg) or the antimuscarinic agent scopolamine (0.5 and 1 mg/kg) failed to produce any locomotor stimulant effect. Olanzapine (1 and 2 mg/kg) and SCH 23390 (0.5 and 1 mg/kg) blocked hyperlocomotion and stereotypy induced by the selective dopamine D1 receptor agonist, SKF 38393 (10 and 25 mg/kg). Olanzapine (1 and 2 mg/kg) blocked hyperlocomotion and stereotypy induced by B-HT 920 (1 and 2 mg/kg), a selective dopamine D2 receptor agonist, whereas it blocked the hyperlocomotion but not stereotypy induced by the non-selective dopamine receptor agonist, apomorphine (0.5 and 1 mg/kg). The higher dose (4 mg/kg) of olanzapine blocked both stereotypy and hyperlocomotion induced by apomorphine. Olanzapine, in mice depleted of their dopamine stores, exhibited properties consistent with those of a D2 partial agonist having strong D1 antagonist property. The atypical nature of its clinical effect may be explained by a dual effect, partial agonistic-like action at D2 receptors and antagonist-like activity at D1 receptors, respectively.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ninan I,Kulkarni SKdoi
10.1007/s002130050877subject
Has Abstractpub_date
1999-02-01 00:00:00pages
175-81issue
2eissn
0033-3158issn
1432-2072journal_volume
142pub_type
杂志文章abstract：:Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days...
journal_title：Psychopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2010-04-01 00:00:00
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journal_title：Psychopharmacology
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1981-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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更新日期：2010-01-01 00:00:00
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更新日期：2020-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00431782
更新日期：1985-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0969-7
更新日期：2008-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432374
更新日期：1980-01-01 00:00:00
abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02245204
更新日期：1994-01-01 00:00:00
abstract：:The noradrenergic system has repeatedly been implicated in the mediation of attentional processes. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 micrograms/kg and 2.5 micrograms/kg) of the alpha 2 adrenoceptor agonist clonidine (CLO) on performance of...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02311180
更新日期：1995-08-01 00:00:00
abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427885
更新日期：1980-01-01 00:00:00
abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00310523
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:The present series of experiments was conducted in order to assess the nature of dopaminergic modulation of the acoustic startle response using agonists and antagonists specific for dopamine D1 and D2 receptors. OBJECTIVES:The objective of the present study was to demonstrate an enhancement of the acoustic s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051020
更新日期：1999-06-01 00:00:00
