Abstract：
RATIONALE:Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact. OBJECTIVES:We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alcohol and examining the way in which this affected the recollection and familiarity components of recognition memory in comparison to a placebo group. METHODS:A double-blind independent design was used, and participants received either alcohol (0.4, 0.6 or 0.8 g/kg) or a placebo drink. Participants encoded word pairs with depth of processing manipulated under generate and read conditions. Recognition memory was assessed and recollective awareness was examined through use of the remember-know procedure. RESULTS:Alcohol produced a dose-dependent reduction in recognition memory associated with recollection, evidenced by decreases in the number of correctly recognised items with 'remember' responses compared to placebo. Recognition based on a familiarity, evidenced by 'know' responses, showed no differences between groups or pattern of reduction compared to the placebo group. However, a negative correlation was found between recognition based on familiarity and levels of intoxication. CONCLUSIONS:Alcohol-induced impairments in recognition memory occur in a dose-dependent manner, specifically driven by reductions in recognition associated with conscious awareness.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bisby JA,Leitz JR,Morgan CJ,Curran HVdoi
10.1007/s00213-009-1709-ysubject
Has Abstractpub_date
2010-01-01 00:00:00pages
67-74issue
1eissn
0033-3158issn
1432-2072journal_volume
208pub_type
杂志文章,随机对照试验abstract：:The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...
journal_title：Psychopharmacology
pub_type： 杂志文章
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 杂志文章
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journal_title：Psychopharmacology
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更新日期：2013-01-01 00:00:00
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更新日期：2016-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 已发布勘误
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更新日期：2019-11-01 00:00:00
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journal_title：Psychopharmacology
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更新日期：1998-12-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2006-08-01 00:00:00
