Effects of mianserin in neuroleptic-induced parkinsonism.

abstract：RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...

journal_title：Psychopharmacology

authors： Shahan TA

更新日期：2003-05-01 00:00:00

abstract：:The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 day...

journal_title：Psychopharmacology

authors： Shaham Y

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...

journal_title：Psychopharmacology

authors： Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

更新日期：2020-12-01 00:00:00

abstract：RATIONALE:Nicotine improves cognitive function in a number of animal models including rats, mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and ease in discovering mechanisms of cognitive improvement. MATERIALS AND METHODS:To further characterize the neural bases of nicotine effect...

journal_title：Psychopharmacology

authors： Eddins D,Petro A,Williams P,Cerutti DT,Levin ED

更新日期：2009-01-01 00:00:00

abstract：:The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...

journal_title：Psychopharmacology

authors： Soubrié P,Jobert A,Thiebot MH

更新日期：1980-01-01 00:00:00

abstract：:Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...

journal_title：Psychopharmacology

authors： Spanagel R,Sillaber I,Zieglgänsberger W,Corrigall WA,Stewart J,Shaham Y

更新日期：1998-10-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...

journal_title：Psychopharmacology

authors： Larrauri JA,Burke DA,Hall BJ,Levin ED

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Marijuana intoxication appears to impair response inhibition, but it is unclear if impaired inhibition and associated brain abnormalities persist after prolonged abstinence among adolescent users. We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent m...

journal_title：Psychopharmacology

authors： Tapert SF,Schweinsburg AD,Drummond SP,Paulus MP,Brown SA,Yang TT,Frank LR

更新日期：2007-10-01 00:00:00

abstract：:Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...

journal_title：Psychopharmacology

authors： Quitkin FM

更新日期：1992-01-01 00:00:00

abstract：:Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...

journal_title：Psychopharmacology

authors： Comer SD,Lac ST,Wyvell CL,Carroll ME

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVES:Recent studies using positron emission tomography (PET) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". The present experim...

journal_title：Psychopharmacology

authors： Gatley SJ,Volkow ND,Gifford AN,Fowler JS,Dewey SL,Ding YS,Logan J

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Repeated intermittent exposure to ketamine has rapid and long-lasting antidepressant effects, but the abuse potential has only been assessed at high doses. Furthermore, while females are more susceptible to depression and more sensitive to ketamine's antidepressant-like effects, the abuse potential for ketami...

journal_title：Psychopharmacology

authors： Wright KN,Strong CE,Addonizio MN,Brownstein NC,Kabbaj M

更新日期：2017-02-01 00:00:00

abstract：:Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...

journal_title：Psychopharmacology

authors： Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

更新日期：1983-01-01 00:00:00

abstract：:Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rou...

journal_title：Psychopharmacology

authors： Figallo EM,Wingard LB Jr

更新日期：1979-03-14 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：:In the present pilot study, an attempt was made to shape and maintain cigarette smoking behavior in rhesus monkeys both with and without the simultaneous use of other reinforcers. Initially, 14 monkeys were trained to suck air and puff on cigarettes using sweetened liquid reinforcer. After smoking had been established...

journal_title：Psychopharmacology

authors： Ando K,Yanagita T

更新日期：1981-01-01 00:00:00

abstract：:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...

journal_title：Psychopharmacology

authors： Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DL

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...

journal_title：Psychopharmacology

authors： Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:Abnormalities of cortical evoked potentials and background electroencephalographic (EEG) frequencies occur in several psychiatric disorders, some of which, especially depression, are associated with hypercortisolaemia. However, there have been few investigations of the effects of exogenously administered cort...

journal_title：Psychopharmacology

authors： Ashton CH,Lunn B,Marsh VR,Young AH

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...

journal_title：Psychopharmacology

authors： West O,Hajek P,McRobbie H

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...

journal_title：Psychopharmacology

authors： Freund N,Jordan CJ,Lukkes JL,Norman KJ,Andersen SL

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...

journal_title：Psychopharmacology

authors： Gorenstein C,de Carvalho SC,Artes R,Moreno RA,Marcourakis T

更新日期：2006-03-01 00:00:00

abstract：RATIONALE:Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of ...

journal_title：Psychopharmacology

authors： Fattore L,Piva A,Zanda MT,Fumagalli G,Chiamulera C

更新日期：2018-02-01 00:00:00

abstract：:Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, doubl...

journal_title：Psychopharmacology

authors： Rasmusson AM,Marx CE,Jain S,Farfel GM,Tsai J,Sun X,Geracioti TD,Hamner MB,Lohr J,Rosse R,Summerall L,Naylor JC,Cusin C,Lang AJ,Raman R,Stein MB

更新日期：2017-08-01 00:00:00

abstract：:In order to validate a new animal model predictive of the profile of antiepileptic drugs, we studied the antagonism by standard antiepileptics of the EEG modifications induced by low-speed IV infusion of pentylenetetrazol (PTZ) in rats. The activity of the drugs was measured by their effects on temporal characteristic...

journal_title：Psychopharmacology

authors： Santucci V,Fournier M,Keane P,Simiand J,Michaud JC,Morre M,Biziere K

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...

journal_title：Psychopharmacology

authors： Albelda N,Bar-On N,Joel D

更新日期：2010-05-01 00:00:00

abstract：:A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 an...

journal_title：Psychopharmacology

authors： Lindquist MP,Götestam KG

更新日期：1977-12-19 00:00:00

abstract：:The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...

journal_title：Psychopharmacology

authors： Sukul NC,Bala SK,Bhattacharyya B

更新日期：1986-01-01 00:00:00

abstract：:Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...

journal_title：Psychopharmacology

authors： Shoemaker WJ,Kosten TA,Muly SM

更新日期：1997-11-01 00:00:00