Abstract:
:Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-administration of ethanol to that of dizocilpine on morphine dependence. Rats were administered morphine (10 mg/kg) twice daily for 9 days. One group received ethanol (1 g/kg) co-administration, another received dizocilpine (0.05 mg/kg) co-administration, and a third served as vehicle controls. On day 10, all rats received naloxone (4 mg/kg) injections and ratings of several classic signs of opiate withdrawal were made. Both ethanol- and dizocilpine-treated rats showed significantly less severe precipitated opiate withdrawal overall, with the ethanol group showing reduced ratings of some specific signs. These results demonstrate that ethanol, like dizocilpine, attenuates the development of morphine dependence. The results are consistent with the action of ethanol at glutamate receptors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Shoemaker WJ,Kosten TA,Muly SMdoi
10.1007/s002130050428subject
Has Abstractpub_date
1997-11-01 00:00:00pages
83-7issue
1eissn
0033-3158issn
1432-2072journal_volume
134pub_type
杂志文章abstract::The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426529
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Behavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD). OBJECTIVES:To test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood. METHODS:We used child and adult ADHD self-report screening scales (WURS-25 and A...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05620-x
更新日期:2020-11-01 00:00:00
abstract::The peripheral BDZ receptor ligand Ro 5-4864 was administered to rabbits in doses ranging from 0.2 to 7 mg/kg IV. Changes in electrocortical activity appeared within 1 min after administration, characterized by trains of slow waves in the posterior sensorimotor and optic cortices (0.6-2 mg/kg) and by grand mal seizure...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180835
更新日期:1986-01-01 00:00:00
abstract::Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244426
更新日期:1991-01-01 00:00:00
abstract::The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244133
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of ...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-017-4793-4
更新日期:2018-02-01 00:00:00
abstract::Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426525
更新日期:1980-01-01 00:00:00
abstract::Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179193
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2278-4
更新日期:2011-09-01 00:00:00
abstract:RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4427-2
更新日期:2016-12-01 00:00:00
abstract::the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433098
更新日期:1980-01-01 00:00:00
abstract::The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177566
更新日期:1988-01-01 00:00:00
abstract::The modulation of spontaneous (social and individual) behaviour as a function of the age of the rat (1, 3, 6, 12, 18 and 24 months) and of scopolamine dose (0.1, 0.2, 0.3 and 0.5 mg/kg) was studied. Observations were conducted during the dark phase of the reverse light/dark schedule using a reintroduction procedure. R...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181945
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100877
更新日期:2001-11-01 00:00:00
abstract:RATIONALE:Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1373-7
更新日期:2009-03-01 00:00:00
abstract::It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464579
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0479-z
更新日期:2006-10-01 00:00:00
abstract:RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05687-6
更新日期:2021-02-01 00:00:00
abstract::The discriminative stimulus (DS) effect of apomorphine was investigated in rats trained in a two-lever, food-reinforcement procedure. Rats were given subcutaneous injections of saline or 0.1 mg/kg apomorphine HCl, 15 min before training sessions. The training dose of apomorphine was chosen to activate dopamine autorec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00690928
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2039-9
更新日期:2011-03-01 00:00:00
abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439445
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically characterized. OBJECTIVE:The aim of the present studies was to characterize the development and expression of ethano...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1266-9
更新日期:2008-12-01 00:00:00
abstract::The inferior colliculus is involved in conveying auditory information of an aversive nature to higher cortical structures. Gradual increases in the electrical stimulation of this structure produce progressive aversive responses from vigilance, through freezing, until escape. Recently, we have shown that microinjection...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050900
更新日期:1999-03-01 00:00:00
abstract:RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1202-3
更新日期:2002-10-01 00:00:00
abstract::This study examined whether the anticholinergic potency of the clinically superior antipsychotic drug clozapine contributes to clozapine's anatomically-selective functional inhibition of the mesolimbic dopamine (DA) system, using an electrical brain-stimulation reward (BSR) paradigm in rats that has been previously sh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246960
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4675-9
更新日期:2017-10-01 00:00:00
abstract:RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2734-9
更新日期:2012-11-01 00:00:00
abstract::Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050285
更新日期:1997-06-01 00:00:00
abstract::Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP. This study was undertaken to assess the effect of chronic in vivo infusion of forskolin on noradrene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432514
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1990-9
更新日期:2010-12-01 00:00:00