Abstract：
RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluated the cognitive performance of depressed patients treated with antidepressants for at least 6 months. METHODS:Patients with major depression (DSM-IV) using imipramine for 2.4+/-0.6 years (mean+/-SE), clomipramine for 2.8+/-1.2 years, fluoxetine for 1.8+/-0.3 years and sertraline for 1.5+/-0.3 years were compared to matched controls (sex, age and educational level) without any psychiatric diagnosis. Memory evaluation consisted of episodic, implicit and working memory tests as well as metamemory assessment. RESULTS:(a) Psychomotor performance of patients taking imipramine was worse than that of controls in inserting pins and a visual reaction time task; on the performance of tapping the difference from controls varied according to dose/weight for patients taking clomipramine and fluoxetine. (b) For memory tests, differences between patients taking sertraline and controls were observed in the number of digits and words recalled; the difference between patients and controls varied according to dose/weight on the number of familiar words correctly completed for patients taking clomipramine and on digit span backward for those taking sertraline. (c) Metamemory was worse in all patient groups irrespective of patients' clinical state. CONCLUSIONS:The impairment in psychomotor and memory performances associated with these antidepressants seems to be of low intensity and of questionable clinical relevance.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Gorenstein C,de Carvalho SC,Artes R,Moreno RA,Marcourakis Tdoi
10.1007/s00213-005-0274-2subject
Has Abstractpub_date
2006-03-01 00:00:00pages
84-92issue
1eissn
0033-3158issn
1432-2072journal_volume
185pub_type
杂志文章abstract：:Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433050
更新日期：1979-10-01 00:00:00
abstract：RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2734-9
更新日期：2012-11-01 00:00:00
abstract：RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gen...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-005-0104-6
更新日期：2005-11-01 00:00:00
abstract：RATIONALE:Schizophrenia is a complex neuropsychiatric disorder characterized, in part, by impaired dopamine signaling. TAK-063 is a selective inhibitor of phosphodiesterase 10A, a key regulator of intracellular signaling pathways that is highly expressed in the striatum. OBJECTIVE:Safety, tolerability, and pharmacokin...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4412-9
更新日期：2016-10-01 00:00:00
abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245438
更新日期：1994-02-01 00:00:00
abstract：RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4293-y
更新日期：2016-07-01 00:00:00
abstract：:Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radial-arm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431932
更新日期：1982-01-01 00:00:00
abstract：:A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245877
更新日期：1992-01-01 00:00:00
abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432135
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-003-1474-2
更新日期：2003-08-01 00:00:00
abstract：:2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050549
更新日期：1998-03-01 00:00:00
abstract：RATIONALE:Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. OBJECTIVES:The aim of the current work was to use ENDS to test concentration...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05400-2
更新日期：2020-03-01 00:00:00
abstract：:Aggressive rats could be differentiated from non-aggressive rats on a lower rate of rearing reactions in the open-field activity, as well as on a weaker aptitude for learning, increasing with the complication of the test. The two groups of rats had comparable activity, and a comparable response to pain. Apomorphine de...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423303
更新日期：1976-07-09 00:00:00
abstract：:A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174688
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND AND RATIONALE:Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effect of a novel nicotinic receptor agonist at α4β2 nicotinic recept...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2712-2
更新日期：2012-10-01 00:00:00
abstract：:The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Eth...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-018-4875-y
更新日期：2018-06-01 00:00:00
abstract：:5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431969
更新日期：1980-02-01 00:00:00
abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-009-1533-4
更新日期：2009-08-01 00:00:00
abstract：RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000637
更新日期：2001-03-01 00:00:00
abstract：:Two groups of socially housed rhesus monkeys were raised under conditions differing in the degree of control or mastery over appetitive stimuli (food, water, and treats) in the 1st year of life. At age 18-24 months, a benzodiazepine receptor inverse agonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), was...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02431537
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-004-1833-7
更新日期：2004-09-01 00:00:00
abstract：:To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244317
更新日期：1991-01-01 00:00:00
abstract：:Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments. Measures of palmar sweating and subjective anxiety showed that anticipation of speaking in public increased anxiety relative to baseline and prestress conditions, a...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00436092
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000630
更新日期：2001-03-01 00:00:00
abstract：:Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4906-8
更新日期：2018-07-01 00:00:00
abstract：:The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomor...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431987
更新日期：1979-01-01 00:00:00
abstract：:Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00735875
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Previous studies have shown that buspirone, a partial 5-HT(1A) receptor agonist, produces antinociceptive effects in rats and mice; Ca(2+) plays a critical role as a second messenger in mediating nociceptive transmission. 5-HT(1A) receptors have been proven to be coupled functionally with various types of Ca(...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1327-4
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1619-z
更新日期：2009-10-01 00:00:00
abstract：RATIONALE:Withdrawal seizure-prone and withdrawal seizure-resistant mice were selectively bred to exhibit differences in handling-induced convulsion severity during ethanol withdrawal. The glutamatergic system has been implicated in seizure activity as well as ethanol withdrawal symptoms. OBJECTIVE:This study assessed...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050933
更新日期：1999-04-01 00:00:00
