Abstract:
RATIONALE:Abnormalities of cortical evoked potentials and background electroencephalographic (EEG) frequencies occur in several psychiatric disorders, some of which, especially depression, are associated with hypercortisolaemia. However, there have been few investigations of the effects of exogenously administered cortisol on waking EEG measures. OBJECTIVES:To examine the effects of subchronic hydrocortisone administration on auditory evoked potentials and background EEG activity. METHODS:Hydrocortisone, 20 mg twice daily, or placebo was administered to 30 normal male volunteers for 7 days in a between-subjects, double-blind trial. Auditory evoked potentials and EEG frequencies were measured on the last day. RESULTS:Hydrocortisone significantly increased the amplitudes of the N1P2 and P300 components of the auditory evoked response, but there was no change in background EEG. CONCLUSION:The results indicate that subchronic hydrocortisone treatment in normal subjects increases the amplitude of auditory evoked potentials, possibly reflecting a central alerting effect.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ashton CH,Lunn B,Marsh VR,Young AHdoi
10.1007/s002130000528subject
Has Abstractpub_date
2000-09-01 00:00:00pages
87-92issue
1eissn
0033-3158issn
1432-2072journal_volume
152pub_type
临床试验,杂志文章,随机对照试验abstract:RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244252
更新日期:1991-01-01 00:00:00
abstract::This study compared the ability of the novel atypical antipsychotic olanzapine with that of clozapine to reverse the d-amphetamine-induced inhibition of substantia nigra (A9) and ventral tegmental area (A10) dopamine (DA) cells. Extracellular single-unit recordings were made from A9 and A10 DA cells in anesthetized ra...
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pub_type: 杂志文章
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abstract:INTRODUCTION:Dopamine D2 receptor occupancy levels needed for the maintenance treatment of schizophrenia remain to be elucidated. We examined 3-year clinical outcomes of patients with schizophrenia who received long-acting injectable risperidone (LAI risperidone) at baseline and investigated their dopamine D2 receptor ...
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abstract:OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1993-01-01 00:00:00
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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更新日期:1998-10-01 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:2000-01-01 00:00:00