Abstract：
:Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform. In the second experiment, groups of rats where given single short tests in the enclosed Y-maze, which was novel to them. The stimulant actions of d-amphetamine on locomotion were obscured by high baseline levels of motor activity induced by the novel environment. Continuous measurements of habituated rats may provide a more sensitive means of evaluating stimulant actions of drugs in screening tests. The observed changes in patterns of onset and offset of increased locomotion and of stereotypy were consistent with the view that these types of behaviour are, to some extent, independently, mediated.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Mumford L,Teixeira AR,Kumar Rdoi
10.1007/BF00431954subject
Has Abstractpub_date
1979-04-25 00:00:00pages
241-5issue
3eissn
0033-3158issn
1432-2072journal_volume
62pub_type
杂志文章abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0666-y
更新日期：2007-04-01 00:00:00
abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1808-9
更新日期：2010-05-01 00:00:00
abstract：:In order to study trends in smoking withdrawal symptoms, 35 participants in a smoking cessation clinic completed four questionnaires daily for 2 weeks. The questionnaire dealt with a variety of symptoms which a factor analysis showed could be grouped into four factors: stimulation, desire to smoke, and physical and ps...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00634151
更新日期：1976-10-20 00:00:00
abstract：BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4512-6
更新日期：2017-03-01 00:00:00
abstract：RATIONALE:Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000605
更新日期：2001-02-01 00:00:00
abstract：:The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist SKF 38393. The amount of time that rats spent grooming themselves was measured continuously for 30 min follo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245478
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:The endogenous cannabinoid system is thought to play a role in reinforcement processes. OBJECTIVES:We tested the effects of five doses of the cannabinoid receptor 1 (CB1) antagonist SR141716 [0, 0.3, 1, 3 and 10 mg/kg intraperitoneal (IP)] on intracranial self-stimulation at the level of the median forebrain...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100804
更新日期：2001-09-01 00:00:00
abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245234
更新日期：1994-01-01 00:00:00
abstract：RATIONALE:Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES:The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of to...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2479-x
更新日期：2012-03-01 00:00:00
abstract：RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1202-3
更新日期：2002-10-01 00:00:00
abstract：:This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427774
更新日期：1984-01-01 00:00:00
abstract：:Two behaviors related to nonreward (omission of water in an enclosure where the rats were habituated to drink) were studied. The time spent licking the bottles during water omission and the time spent drinking during a subsequent 5-min drinking session (water available) were recorded. The drinking session was performe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428038
更新日期：1978-09-15 00:00:00
abstract：RATIONALE:Psychostimulant sensitization heightens behavioral and motivational responses to reward-associated stimuli; however, its effects on stimuli associated with reward absence are less understood. OBJECTIVES:We examined whether amphetamine sensitization alters performance during Pavlovian-instrumental transfer (P...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3144-3
更新日期：2013-11-01 00:00:00
abstract：:Tardive dyskinesia has been hypothesized to be caused by a neuroleptic-induced dopamine hypersensitivity in the nigrostriatal system. This study evaluated with dopamine antagonists the possibility that such dopamine hypersensitivity extends to the tuberoinfundibular dopamine (TIDA) system, which regulates, by inhibiti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428314
更新日期：1979-01-01 00:00:00
abstract：:Aggressive rats could be differentiated from non-aggressive rats on a lower rate of rearing reactions in the open-field activity, as well as on a weaker aptitude for learning, increasing with the complication of the test. The two groups of rats had comparable activity, and a comparable response to pain. Apomorphine de...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423303
更新日期：1976-07-09 00:00:00
abstract：RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3161-2
更新日期：2013-12-01 00:00:00
abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244179
更新日期：1991-01-01 00:00:00
abstract：:Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00445568
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-006-0442-z
更新日期：2007-03-01 00:00:00
abstract：:A study was performed on the effect of ethanol on the basal and K+-evoked efflux of endogenous GABA from rat hypothalamic fragments. The amount of GABA present in the medium and in the tissue was measured by radioreceptor assay. In vitro addition of ethanol (50 and 100 mM) enhanced the K+-evoked efflux of GABA in a Ca...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00181959
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-004-1966-8
更新日期：2005-02-01 00:00:00
abstract：:The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02249415
更新日期：1996-05-01 00:00:00
abstract：RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051039
更新日期：1999-07-01 00:00:00
abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3816-7
更新日期：2015-05-01 00:00:00
abstract：:A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s002130050982
更新日期：1999-05-01 00:00:00
abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050877
更新日期：1999-02-01 00:00:00
abstract：RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-013-3199-1
更新日期：2013-11-01 00:00:00
abstract：RATIONALE:One third of US smokers are intermittent smokers (ITS) who do not smoke daily. Unlike daily smokers (DS), whose smoking is negatively reinforced by withdrawal relief, ITS may be motivated by immediate positive reinforcement. In contrast, incentive salience theory posits hypothesis that "liking" of drug effect...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4682-x
更新日期：2017-10-01 00:00:00
abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...
journal_title：Psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1007/s002130050103
更新日期：1996-11-01 00:00:00
abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427314
更新日期：1985-01-01 00:00:00
