Abstract:
RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to characterize the effect of various doses of amphetamine on the physiological response to a predominantly emotional stressor (forced swim) when the drug was given immediately before stress; (ii) to study if an interaction appears when the drug was given 30 min or 7 days before swim; and (iii) to know whether cocaine causes similar effects when given just before stress. Adult male rats were used and plasma levels of ACTH, corticosterone, and glucose were the outcomes. RESULTS:Amphetamine caused a dose-dependent activation of the HPA axis, but all doses reduced HPA and glycemic responses to swim when given just before the stressor. Importantly, during the post-swim period, the stressor potently inhibited the ACTH response to amphetamine, demonstrating mutual inhibition between the two stimuli. The highest dose of amphetamine also reduced the response to swim when given 30 min before stress, whereas it caused HPA sensitization when given 7 days before. Cocaine also reduced stress-induced HPA activation when given just before swim. CONCLUSIONS:The present results demonstrate a negative synergy between psychostimulants (amphetamine and cocaine) and stress regarding HPA and glucose responses when rats were exposed simultaneously to both stimuli. The inhibitory effect of amphetamine is also observed when given shortly before stress, but not some days before.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Gagliano H,Ortega-Sanchez JA,Nadal R,Armario Adoi
10.1007/s00213-017-4675-9subject
Has Abstractpub_date
2017-10-01 00:00:00pages
2859-2869issue
19eissn
0033-3158issn
1432-2072pii
10.1007/s00213-017-4675-9journal_volume
234pub_type
杂志文章abstract::The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555228
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Withdrawal seizure-prone and withdrawal seizure-resistant mice were selectively bred to exhibit differences in handling-induced convulsion severity during ethanol withdrawal. The glutamatergic system has been implicated in seizure activity as well as ethanol withdrawal symptoms. OBJECTIVE:This study assessed...
journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246082
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abstract::The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439266
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050096
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050237
更新日期:1997-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychopharmacology
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更新日期:1980-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050168
更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-009-1758-2
更新日期:2010-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4368-9
更新日期:2016-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
abstract::Exposure to 10 min of footshock stress (1 mA; 0.5 s on, with a mean off period of 40 s) reinstated heroin-seeking behavior in heroin-experienced, drug-free rats after many sessions of extinction and up to 6 weeks after last exposure to heroin. In reinstating the behavior, the footshock mimicked the effect of a non-con...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246300
更新日期:1995-06-01 00:00:00
abstract:RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3689-9
更新日期:2015-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431749
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1381-7
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00429199
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1984-01-01 00:00:00
abstract:RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051048
更新日期:1999-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1644-2
更新日期:2004-03-01 00:00:00