Glutamate uptake in mice bred for ethanol withdrawal severity.

abstract：:The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...

journal_title：Psychopharmacology

authors： Austermann M,Grotemeyer KH,Evers S,Rödding D,Husstedt IW

更新日期：1998-08-01 00:00:00

abstract：:The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...

journal_title：Psychopharmacology

authors： Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would prod...

journal_title：Psychopharmacology

authors： Butelman ER,Harris TJ,Kreek MJ

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Caveolin-1 (CAV1) is a structural protein critical for spatial organization of neuronal signaling molecules. Whether CAV1 is required for long-lasting neuronal plasticity remains unknown. OBJECTIVE AND METHODS:We sought to examine the effects of CAV1 knockout (KO) on functional plasticity and hypothesized th...

journal_title：Psychopharmacology

authors： Eisinger KRT,Chapp AD,Swanson SP,Tam D,Lopresti NM,Larson EB,Thomas MJ,Lanier LM,Mermelstein PG

更新日期：2020-09-01 00:00:00

abstract：:Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...

journal_title：Psychopharmacology

authors： Glick SD,Cox RD

更新日期：1978-05-31 00:00:00

abstract：:The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...

journal_title：Psychopharmacology

authors： Molander L,Randrup A

更新日期：1976-09-17 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00

abstract：RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...

journal_title：Psychopharmacology

authors： Tarland E,Franke RT,Fink H,Pertz HH,Brosda J

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Psychostimulant sensitization heightens behavioral and motivational responses to reward-associated stimuli; however, its effects on stimuli associated with reward absence are less understood. OBJECTIVES:We examined whether amphetamine sensitization alters performance during Pavlovian-instrumental transfer (P...

journal_title：Psychopharmacology

authors： Shiflett MW,Riccie M,DiMatteo R

更新日期：2013-11-01 00:00:00

abstract：:Recent work with humans and animals has suggested that the cholinergic system plays an important role in the active control of attention. This study was designed to investigate the effects of scopolamine upon subjects' ability to utilize knowledge of the spatial probability bias in a display in the detection of briefl...

journal_title：Psychopharmacology

authors： Dunne MP,Hartley LR

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for...

journal_title：Psychopharmacology

authors： Nephew BC,Febo M

更新日期：2010-03-01 00:00:00

abstract：:Adult rats that were gestationally exposed to cocaine and control offspring were examined for their sensitivity to challenge doses of cocaine. Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg per 3 cc cocaine hydrochloride daily on gestational days 8-20, pair-fed da...

journal_title：Psychopharmacology

authors： Heyser CJ,Rajachandran L,Spear NE,Spear LP

更新日期：1994-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...

journal_title：Psychopharmacology

authors： Yang F,Wang K,Du X,Deng H,Wu HE,Yin G,Ning Y,Huang X,Teixeira AL,de Quevedo J,Soares JC,Li X,Lang X,Zhang XY

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naïve (FEDN) schizophrenia. METHODS:Demographic and lipid parameters were gathered from 297 FEDN schizophr...

journal_title：Psychopharmacology

authors： Tian Y,Wang D,Wei G,Wang J,Zhou H,Xu H,Dai Q,Xiu M,Chen D,Wang L,Zhang XY

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...

journal_title：Psychopharmacology

authors： Mangieri RA,Hong KI,Piomelli D,Sinha R

更新日期：2009-07-01 00:00:00

abstract：:The behavioral responsiveness to challenge doses of the D2 agonist quinpirole was examined in 21-day-old normal offspring (experiment 1) as well as offspring exposed gestationally to cocaine (experiment 2). In both experiments weanling rats received a subcutaneous injection of 0 (0.9% saline), 0.04, 0.08, 0.5, or 1.0 ...

journal_title：Psychopharmacology

authors： Moody CA,Frambes NA,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...

journal_title：Psychopharmacology

authors： Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

更新日期：1982-01-01 00:00:00

abstract：:Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...

journal_title：Psychopharmacology

authors： Sills TL,Vaccarino FJ

更新日期：1991-01-01 00:00:00

abstract：:The effects of bromocriptine, lisuride and apomorphine on specific binding of 3H-spiroperidol to homogenates of rat caudate nucleus were studied. (+)-Butaclamol was used to define specific binding. Bromocriptine and lisuride inhibited binding markedly, in vitro and also 30 min after in vivo injection. Bromocriptine co...

journal_title：Psychopharmacology

authors： Weir RL,Hruska RE,Silbergeld EK

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects. OBJECTIVES:This study represents a syst...

journal_title：Psychopharmacology

authors： Walentiny DM,Vann RE,Warner JA,King LS,Seltzman HH,Navarro HA,Twine CE Jr,Thomas BF,Gilliam AF,Gilmour BP,Carroll FI,Wiley JL

更新日期：2010-06-01 00:00:00

abstract：:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...

journal_title：Psychopharmacology

authors： Sargent P,Williamson DJ,Pearson G,Odontiadis J,Cowen PJ

更新日期：1997-08-01 00:00:00

abstract：:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...

journal_title：Psychopharmacology

authors： Müller U,Steffenhagen N,Regenthal R,Bublak P

更新日期：2004-12-01 00:00:00

abstract：:Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain u...

journal_title：Psychopharmacology

authors： Chan-Palay V

更新日期：1992-01-01 00:00:00

abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...

journal_title：Psychopharmacology

authors： Robinson OJ,Sahakian BJ

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function. OBJECTIVE:The aim of this study was to investigate these alterations during a perturbed homeostatic state. METHODS:Fifteen patients with schizophrenia and 13...

journal_title：Psychopharmacology

authors： Elman I,Rott D,Green AI,Langleben DD,Lukas SE,Goldstein DS,Breier A

更新日期：2004-11-01 00:00:00

abstract：:Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only...

journal_title：Psychopharmacology

authors： Hienz RD,Spear DJ,Pyle DA,Brady JV

更新日期：1995-11-01 00:00:00

abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...

journal_title：Psychopharmacology

authors： Iwamoto ET

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00

abstract：RATIONALE:Toluene exposure during brain growth spurt has been shown to elevate the seizure susceptibility induced by N-methyl-D: -aspartate (NMDA). In the present study, behavioral responses to NMDA antagonists were studied to determine whether neonatal toluene exposure produces residual deficits in the NMDA glutamater...

journal_title：Psychopharmacology

authors： Chien TH,Chan MH,Tang YC,Chen HH

更新日期：2005-11-01 00:00:00