The influence of acetylsalicylic acid on cognitive processing: an event-related potentials study.

abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...

journal_title：Psychopharmacology

authors： Rezvani AH,Caldwell DP,Levin ED

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...

journal_title：Psychopharmacology

authors： Uhlírová L,Sustková-Fiserová M,Krsiak M

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...

journal_title：Psychopharmacology

authors： Newman JL,Carroll ME

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...

journal_title：Psychopharmacology

authors： Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid N

更新日期：2011-09-01 00:00:00

abstract：RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...

journal_title：Psychopharmacology

authors： Hearn AJ,Gallagher P,Owen BM,Smith MS,Watson S,Young AH

更新日期：2004-02-01 00:00:00

abstract：:The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...

journal_title：Psychopharmacology

authors： Deminière JM,Taghzouti K,Tassin JP,Le Moal M,Simon H

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...

journal_title：Psychopharmacology

authors： Krabbendam L,Aleman A

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:Alcohol-associated cues elicit craving in human addicts but little is known about craving mechanisms. Current animal models focus on relapse and this may confound the effect of environmental cues. OBJECTIVES. To develop a model to study the effects of environmental cues on alcohol consumption in animals not e...

journal_title：Psychopharmacology

authors： Pickering C,Liljequist S

更新日期：2003-07-01 00:00:00

abstract：:This study examined the effects of intrahippocampal injections of scopolamine (a muscarinic antagonist drug) on performance of a working-memory task (contingently reinforced T-maze alternation) and a reference-memory task (visual discrimination) by the same rats in the same maze. Rats in the first shipment were traine...

journal_title：Psychopharmacology

authors： Brito GN,Davis BJ,Stopp LC,Stanton ME

更新日期：1983-01-01 00:00:00

abstract：:Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LiCl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. ...

journal_title：Psychopharmacology

authors： Wegener G,Smith DF,Rosenberg R

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...

journal_title：Psychopharmacology

authors： Slifstein M,Abi-Dargham A,Girgis RR,Suckow RF,Cooper TB,Divgi CR,Sokoloff P,Leriche L,Carberry P,Oya S,Joseph SK,Guiraud M,Montagne A,Brunner V,Gaudoux F,Tonner F

更新日期：2020-02-01 00:00:00

abstract：RATIONALE:Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures. OBJECTIVES:We investigated whether repeated withdrawal experience increases withdrawal-induced anxiety and stress, and if it changes ...

journal_title：Psychopharmacology

authors： Borlikova GG,Le Merrer J,Stephens DN

更新日期：2006-04-01 00:00:00

abstract：:This pilot study was conducted to evaluate the potential of the new antidepressant moclobemide to inhibit the cytochrome enzyme P4502D6 (CYP2D6) using the cough suppressant dextromethorphan as a substrate in four extensive metabolizers (EM) of debrisoquine. The subjects received seven oral doses of 20 mg dextromethorp...

journal_title：Psychopharmacology

authors： Härtter S,Dingemanse J,Baier D,Ziegler G,Hiemke C

更新日期：1998-01-01 00:00:00

abstract：:Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...

journal_title：Psychopharmacology

authors： Brown SL,Charney DS,Woods SW,Heninger GR,Tallman J

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS). The mechanisms by which opioid analgesics work are understood, but this class of drugs is no...

journal_title：Psychopharmacology

authors： Kivell B,Prisinzano TE

更新日期：2010-06-01 00:00:00

abstract：:Because of the increasing demand for refined techniques to record drug-induced motoric changes, we designed and evaluated a computer monitoring system with continuous measurement of different parameters of rat motor activity. This system is particularly useful for chronic drug studies because it can characterize patte...

journal_title：Psychopharmacology

authors： Stoff DM,Stauderman K,Wyatt RJ

更新日期：1983-01-01 00:00:00

abstract：:Recently, evidence has emerged showing that the behavioural and hormonal features of fear extinction are altered as a result of reproductive experience in both rats and humans. The current set of experiments sought to determine whether reproductive experience also alters the molecular features of fear extinction. In a...

journal_title：Psychopharmacology

authors： Tang S,Graham BM

更新日期：2019-01-01 00:00:00

abstract：:In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...

journal_title：Psychopharmacology

authors： Del Zompo M,Tocco F,Marrosu F,Passino N,Corsini GU

更新日期：1983-01-01 00:00:00

abstract：:A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behavio...

journal_title：Psychopharmacology

authors： Usuda S,Nishikori K,Noshiro O,Maeno H

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. OBJECTIVES:The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. METHODS:In expe...

journal_title：Psychopharmacology

authors： Czoty PW,Tran P,Thomas LN,Martin TJ,Grigg A,Blough BE,Beveridge TJ

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Memories can return to a labile state and become amenable to modification by pharmacological and behavioral manipulations after retrieval. This process may reduce the impact of aversive memories and provide a promising therapeutic technique for the treatment of anxiety disorders. A growing body of evidence su...

journal_title：Psychopharmacology

authors： Hu J,Wang Z,Feng X,Long C,Schiller D

更新日期：2019-01-01 00:00:00

abstract：:Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...

journal_title：Psychopharmacology

authors： Verberne AJ,Taylor DA,Fennessy MR

更新日期：1981-01-01 00:00:00

abstract：:In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...

journal_title：Psychopharmacology

authors： Santori EM,Schmidt DE,Kalivas PW,Horita A

更新日期：1981-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ

更新日期：1981-01-01 00:00:00

abstract：:The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...

journal_title：Psychopharmacology

authors： Gray NS,Pickering AD,Hemsley DR,Dawling S,Gray JA

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：:Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...

journal_title：Psychopharmacology

authors： Sansone M

更新日期：1980-01-01 00:00:00

abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...

journal_title：Psychopharmacology

authors： Atrens DM,Becker FT,Hunt GE

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Acute physical dependence refers to the withdrawal syndrome precipitated by an opioid antagonist administered several hours after either a single dose or a short-term infusion of an opioid agonist. OBJECTIVES:We examined the mechanism of nicotine-induced attenuation of naloxone-precipitated withdrawal syndro...

journal_title：Psychopharmacology

authors： Araki H,Kawakami KY,Jin C,Suemaru K,Kitamura Y,Nagata M,Futagami K,Shibata K,Kawasaki H,Gomita Y

更新日期：2004-02-01 00:00:00