Abstract：
RATIONALE:Memories can return to a labile state and become amenable to modification by pharmacological and behavioral manipulations after retrieval. This process may reduce the impact of aversive memories and provide a promising therapeutic technique for the treatment of anxiety disorders. A growing body of evidence suggests that the mammalian neuropeptide oxytocin (OT) plays a role in the regulation of emotional memories in animals. However, the effects of OT on threat memory in humans remain largely unknown. OBJECTIVES:This study aimed to investigate the effects of OT administration following threat memory retrieval on subsequent memory expression in human participants. METHODS:In a double-blind, randomized, placebo-controlled, between-subject design, 61 healthy human individuals completed a 3-day experiment. All the participants underwent threat conditioning on day 1. On day 2, the participants were randomized to receive an intranasal dose of OT (40 IU) or placebo after memory retrieval, or an intranasal dose of OT (40 IU) without retrieval. On day 3, the participants were tested for extinction and reinstatement. RESULTS:On day 3, all groups showed equivalent stimulus discrimination during the early phase of extinction. However, the group that received OT following a memory reminder showed a greater decline in stimulus discrimination by the late phase of extinction relative to the two other groups. CONCLUSIONS:The results indicate that OT did not block reconsolidation to prevent the return of threat memory but rather interacted with post-retrieval processes to facilitate next day extinction. The study provides novel preliminary evidence for the role of OT in human threat memory.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Hu J,Wang Z,Feng X,Long C,Schiller Ddoi
10.1007/s00213-018-5074-6subject
Has Abstractpub_date
2019-01-01 00:00:00pages
293-301issue
1eissn
0033-3158issn
1432-2072pii
10.1007/s00213-018-5074-6journal_volume
236pub_type
杂志文章,随机对照试验abstract：:Pigeons were trained to acquire a new 4-response sequence in each session by pecking three keys in a predetermined order. The key color varied for each step under the chained schedule, but there was only one key color under the tandem schedule. Under the reset contingency, incorrect responses produced a reset of the 4...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426823
更新日期：1976-09-29 00:00:00
abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00215480
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0551-8
更新日期：2006-12-01 00:00:00
abstract：RATIONALE:Nicotine improves cognitive function in a number of animal models including rats, mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and ease in discovering mechanisms of cognitive improvement. MATERIALS AND METHODS:To further characterize the neural bases of nicotine effect...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1287-4
更新日期：2009-01-01 00:00:00
abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02245134
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3873-6
更新日期：2015-07-01 00:00:00
abstract：RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2185-8
更新日期：2011-07-01 00:00:00
abstract：RATIONALE:The social interaction test is a valuable behavioural model for testing anxiolytic drugs in rodents, quantifying the level of social behaviour between pairs of rats. OBJECTIVE:The aim of the present study was to assess the appropriateness of the social interaction test for use with a Sprague-Dawley rat line,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1914-7
更新日期：2004-12-01 00:00:00
abstract：RATIONALE:We recently demonstrated that blocking specific nicotinic acetylcholine receptors (nAChRs) abolishes the conditioned reinforcing properties of ethanol-associated cues in rat, suggesting nAChRs as promising pharmacological targets for prevention of cue-induced relapse. OBJECTIVES:The present study investigate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1957-x
更新日期：2010-10-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00427446
更新日期：1984-01-01 00:00:00
abstract：RATIONALE/OBJECTIVES:Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies. Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system ha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2678-0
更新日期：2012-08-01 00:00:00
abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3610-6
更新日期：2014-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426674
更新日期：1979-02-28 00:00:00
abstract：RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1861-3
更新日期：2004-10-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433246
更新日期：1980-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1522-y
更新日期：2003-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244411
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2013-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246154
更新日期：1995-05-01 00:00:00
abstract：RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2015-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00213-015-3967-1
更新日期：2015-09-01 00:00:00
abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0805-0
更新日期：2007-09-01 00:00:00
abstract：RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2005-09-01 00:00:00
abstract：RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1254-4
更新日期：2003-09-01 00:00:00
abstract：:The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of de...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1978-01-31 00:00:00
abstract：:The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00518186
更新日期：1987-01-01 00:00:00
