当前位置： SCI文献检索 > PSYCHOPHARMACOLOGY期刊下所有文献 > Apomorphine, d-amphetamine, strychnine and yohimbine do not alter prepulse inhibition of the acoustic startle reflex.

Apomorphine, d-amphetamine, strychnine and yohimbine do not alter prepulse inhibition of the acoustic startle reflex.

Abstract：

:Rats were presented with noise bursts alone or noise bursts 60 ms after presentation of either a 60 dB or an 80 dB prepulse after injection of the dopamine agonists apomorphine (3 mg/kg) or d-amphetamine (4 mg/kg), the glycine antagonist strychnine (1.5 mg/kg) or the alpha 2 antagonist yohimbine (5 mg/kg). Presentation of prepulses inhibited startle, with greater inhibition following an 80 dB versus 60 dB prepulse. Apomorphine, d-amphetamine and strychnine increased overall startle levels but did not attenuate prepulse inhibition, since the absolute change in startle following prepulse presentation was significantly greater after administration of these drugs. A lower dose of apomorphine also increased startle but had no effect on prepulse inhibition using test intervals of 10, 60, 100, 200 or 1000 ms. While these drugs did decrease per cent prepulse inhibition, this seemed wholly attributable to their increasing overall startle levels, rather than a real attenuation of prepulse inhibition. Yohimbine did not alter either startle baseline or prepulse inhibition. The results do not support the conclusion that overactivity of dopamine systems attenuates prepulse inhibition and, in addition, suggest that prepulse inhibition does not result from activation of either glycine or norepinephrine projecting to alpha 2 adrenergic receptors.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Davis M

doi

10.1007/BF00174500

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

151-6

issue

2

eissn

0033-3158

issn

1432-2072

journal_volume

95

pub_type

杂志文章

相关文献

PSYCHOPHARMACOLOGY文献大全
  • MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function.

    abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-006-0434-z

    authors： Kuypers KP,Samyn N,Ramaekers JG

    更新日期：2006-09-01 00:00:00

  • Benzodiazepines and risk of pneumonia in schizophrenia: a nationwide case-control study.

    abstract：OBJECTIVES:To investigate the relationship between benzodiazepine and risk of developing pneumonia in patients with schizophrenia, whose benzodiazepine dosage and usage frequency was higher than that of the general population. METHODS:We conducted a nested case-control study to assess the association between benzodiaz...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-5039-9

    authors： Cheng SY,Chen WY,Liu HC,Yang TW,Pan CH,Yang SY,Kuo CJ

    更新日期：2018-11-01 00:00:00

  • Facilitation of discrimination transfers under amphetamine: the relative control by S+ and S- and general transfer effects.

    abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00179945

    authors： Weiner I,Feldon J,Ben-Horin E

    更新日期：1987-01-01 00:00:00

  • Characterization of the V1a antagonist, JNJ-17308616, in rodent models of anxiety-like behavior.

    abstract：RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-008-1354-x

    authors： Bleickardt CJ,Mullins DE,Macsweeney CP,Werner BJ,Pond AJ,Guzzi MF,Martin FD,Varty GB,Hodgson RA

    更新日期：2009-03-01 00:00:00

  • An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress.

    abstract：:Chronic exposure to very mild unpredictable stress has previously been found to depress the consumption of, and preference for, highly palatable sweet solutions. The present study used the place conditioning procedure to investigate whether these effects result from a decreased sensitivity to reward. Rats were subject...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02244188

    authors： Papp M,Willner P,Muscat R

    更新日期：1991-01-01 00:00:00

  • Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum.

    abstract：:The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130050536

    authors： Crawford CA,McDougall SA,Meier TL,Collins RL,Watson JB

    更新日期：1998-03-01 00:00:00

  • Environment-dependent effects of ethanol on DOPAC and HVA in various brain regions of ethanol-tolerant rats.

    abstract：:The development of tolerance to the behavioral and biochemical effects of ethanol was studied. Rats were made tolerant to ethanol by the administration of daily ethanol injections (3 g/kg, IP) for 7 and 28 days. Tolerance developed both to the behavioral (hypothermic, sedative) and biochemical (accumulation of dopamin...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02244097

    authors： Liljequist S,Ekman A,Snape B,Söderpalm B,Engel JA

    更新日期：1990-01-01 00:00:00

  • Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.

    abstract：RATIONALE/OBJECTIVES:Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies. Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system ha...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-012-2678-0

    authors： Domschke K,Klauke B,Winter B,Gajewska A,Herrmann MJ,Warrings B,Mühlberger A,Wosnitza K,Dlugos A,Naunin S,Nienhaus K,Fobker M,Jacob C,Arolt V,Pauli P,Reif A,Zwanzger P,Deckert J

    更新日期：2012-08-01 00:00:00

  • Compulsive drug seeking by rats under punishment: effects of drug taking history.

    abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-007-0805-0

    authors： Pelloux Y,Everitt BJ,Dickinson A

    更新日期：2007-09-01 00:00:00

  • Evidence for behavioral sensitization to cocaine in preweanling rat pups.

    abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130050653

    authors： Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

    更新日期：1998-07-01 00:00:00

  • Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations.

    abstract：:Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00555210

    authors： Pomara N,Stanley B,Block R,Guido J,Russ D,Berchou R,Stanley M,Greenblatt DJ,Newton RE,Gershon S

    更新日期：1984-01-01 00:00:00

  • Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area.

    abstract：RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-014-3796-7

    authors： Yap JJ,Chartoff EH,Holly EN,Potter DN,Carlezon WA Jr,Miczek KA

    更新日期：2015-05-01 00:00:00

  • Basal and stress-induced modulation of activity-regulated cytoskeletal associated protein (Arc) in the rat brain following duloxetine treatment.

    abstract：RATIONALE:Therapeutic efficacy of antidepressant drugs appears to be related to their ability in producing neuroadaptive changes that restore normal brain function. Activity-regulated cytoskeletal associated protein (Arc) is an effector immediate early gene that plays a fundamental role in activity-dependent neural pla...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-008-1276-7

    authors： Molteni R,Calabrese F,Mancini M,Racagni G,Riva MA

    更新日期：2008-12-01 00:00:00

  • Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS.

    abstract：RATIONALE:In cell culture systems, agonists can promote the phosphorylation and internalization of receptors coupled to G proteins (GPCR), leading to their desensitization. However, in the CNS opioid agonists promote a profound desensitization of their analgesic effects without diminishing the presence of their recepto...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00213-005-2248-9

    authors： Garzón J,Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P

    更新日期：2005-06-01 00:00:00

  • Association of OPRM1 A118G variant with the relative reinforcing value of nicotine.

    abstract：RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opi...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-006-0504-2

    authors： Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman C

    更新日期：2006-10-01 00:00:00

  • Altered fecal microbiota composition in the Flinders sensitive line rat model of depression.

    abstract：RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-5094-2

    authors： Tillmann S,Abildgaard A,Winther G,Wegener G

    更新日期：2019-05-01 00:00:00

  • Lipopolysaccharide-induced hypoactivity and behavioral tolerance development are modulated by the light-dark cycle in male and female rats.

    abstract：RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-003-1554-3

    authors： Franklin AE,Engeland CG,Kavaliers M,Ossenkopp KP

    更新日期：2003-12-01 00:00:00

  • Noradrenergic modulation of risk/reward decision making.

    abstract：RATIONALE:Catecholamine transmission modulates numerous cognitive and reward-related processes that can subserve more complex functions such as cost/benefit decision making. Dopamine has been shown to play an integral role in decisions involving reward uncertainty, yet there is a paucity of research investigating the c...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-015-3904-3

    authors： Montes DR,Stopper CM,Floresco SB

    更新日期：2015-08-01 00:00:00

  • Preclinical pharmacology of F-98214-TA, a novel potent serotonin and norepinephrine uptake inhibitor with antidepressant and anxiolytic properties.

    abstract：RATIONALE:Serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitors (SNRIs) have been proposed to have a higher efficacy and/or faster onset of action than previously available antidepressants. OBJECTIVES:We examined in biochemical, electrophysiological and behavioural assays the antidepressant properties of (S)-(...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-005-0087-3

    authors： Artaiz I,Zazpe A,Innerárity A,Del Olmo E,Díaz A,Ruiz-Ortega JA,Castro E,Pena R,Labeaga L,Pazos A,Orjales A

    更新日期：2005-11-01 00:00:00

  • Effects of delta-aminolaevulinic acid administration on social behaviour in the laboratory mouse.

    abstract：:Ethologic analysis has been used to study the behavioural effects following injection of delta-aminolaevulinic acid (ALA) in mice. After a dose level of 1.6 mmol ALA/kg, male and female mice showed periods of immobility and scanned less frequently than saline-injected controls. Exploration of the cage was significantl...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00426726

    authors： Cutler MG,Moore MR,Ewart FG

    更新日期：1979-03-22 00:00:00

  • Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine.

    abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-020-05558-0

    authors： McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

    更新日期：2020-09-01 00:00:00

  • Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

    abstract：RATIONALE:Cannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats. OBJECTIVES:To compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-020-05481-4

    authors： Bis-Humbert C,García-Cabrerizo R,García-Fuster MJ

    更新日期：2020-06-01 00:00:00

  • Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics.

    abstract：:A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02245590

    authors： Miczek KA,Weerts EM,Vivian JA,Barros HM

    更新日期：1995-09-01 00:00:00

  • Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes.

    abstract：RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-006-0431-2

    authors： Duke AN,Platt DM,Cook JM,Huang S,Yin W,Mattingly BA,Rowlett JK

    更新日期：2006-08-01 00:00:00

  • The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze.

    abstract：:Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02244646

    authors： Chopin P,Briley M

    更新日期：1993-01-01 00:00:00

  • The effects of chronic administration and withdrawal of (+)-amphetamine on seizure threshold and endogenous catecholamine concentrations and their rates of biosynthesis in mice.

    abstract：:The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00431736

    authors： Riffee WH,Gerald MC

    更新日期：1977-01-31 00:00:00

  • Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.

    abstract：RATIONALE:Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:The present experime...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-013-3285-4

    authors： Nunes EJ,Randall PA,Estrada A,Epling B,Hart EE,Lee CA,Baqi Y,Müller CE,Correa M,Salamone JD

    更新日期：2014-02-01 00:00:00

  • Effects of diazepam on operant behavior in man.

    abstract：:The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00426457

    authors： Carlton PL,Siegel JL,Murphree HB,Cook L

    更新日期：1981-01-01 00:00:00

  • Noradrenergic and behavioural effects of naloxone injected in the locus coeruleus of morphine-dependent rats and their control by clonidine.

    abstract：:Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a withdrawal syndrome...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00187263

    authors： Esposito E,Kruszewska A,Ossowska G,Samanin R

    更新日期：1987-01-01 00:00:00

  • Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task demands.

    abstract：RATIONALE:Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. OBJECTIVES:To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects f...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-002-1005-6

    authors： Hahn B,Shoaib M,Stolerman IP

    更新日期：2002-07-01 00:00:00