Abstract:
:The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an anti-conflict-effect for this drug. No tolerance to the anti-punishment-effect was seen after chronic carbamazepine administration.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Almeida RN,Leite JRdoi
10.1007/BF02244411subject
Has Abstractpub_date
1990-01-01 00:00:00pages
227-9issue
2eissn
0033-3158issn
1432-2072journal_volume
100pub_type
杂志文章abstract:RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05207-1
更新日期:2019-03-01 00:00:00
abstract::A total of 97 patients, who participated in two studies on the relationship between the clinical effect and plasma levels of imipramine and clomipramine, were examined for improvement curves by use of weekly ratings on the Hamilton Depression Scale (HDS). Although we confirmed that our six-item HDS subscale, in contra...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427459
更新日期:1984-01-01 00:00:00
abstract::Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050348
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4579-8
更新日期:2017-05-01 00:00:00
abstract::Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244887
更新日期:1993-01-01 00:00:00
abstract::The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00217071
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4155-z
更新日期:2016-02-01 00:00:00
abstract::The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445554
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. OBJECTIVES:The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. METHODS:In expe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3875-4
更新日期:2015-07-01 00:00:00
abstract::Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02439600
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000478
更新日期:2000-08-01 00:00:00
abstract:RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3684-1
更新日期:2015-02-01 00:00:00
abstract::Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+). This conversion of haloperidol to HP+ appears to be similar to the activation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to N-methyl-4-phenyl pyridinium ion (MPP+). MPP+ is responsible for the dam...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246077
更新日期:1995-10-01 00:00:00
abstract::Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496071
更新日期:1979-08-08 00:00:00
abstract::It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244064
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night. OBJECTIVE:The present study investigated the effects of alcohol on the serum concentrations of TSH in healthy volu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-003-1532-9
更新日期:2003-11-01 00:00:00
abstract:RATIONALE:The influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established. OBJECTIVE:This work analyzes the sexual effects of dopamine (DA) receptor activation in the mPO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5142-y
更新日期:2019-04-01 00:00:00
abstract::The effects of single and repeated electroconvulsive treatment (ECT) on beta-endorphin (beta-EP), cortisol, growth hormone (GH) and prolactin (Prl) plasma levels were investigated in nine depressed patients. Blood samples were monitored a day before ECT, the day of the first and sixth ECT (0, 30, 60 and 90 min after s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02439598
更新日期:1987-01-01 00:00:00
abstract::This study examined the role of the strychnine-insensitive glycine binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is an operational measure of gating processes which normally lead to a diminished ASR when a startling stimulus is preceded by a weak pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050220
更新日期:1997-03-01 00:00:00
abstract:RATIONALE:It is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects. OBJECTIVES:This study aims to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3163-0
更新日期:2013-12-01 00:00:00
abstract:RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100726
更新日期:2001-06-01 00:00:00
abstract::Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antag...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050138
更新日期:1996-12-01 00:00:00
abstract::Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244285
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000602
更新日期:2000-12-01 00:00:00
abstract:RATIONALE:Genetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption. OBJECTIVES:Studies were performed to determine whether selective breeding could be used to create lines of mice with different magnitudes of locomotor sensitization to methampheta...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2086-2
更新日期:2011-04-01 00:00:00
abstract:RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1779-x
更新日期:2010-04-01 00:00:00
abstract:RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0627-5
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therap...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1804-z
更新日期:2004-09-01 00:00:00
abstract::Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050910
更新日期:1999-03-01 00:00:00
abstract:RATIONALE:Receptor mechanisms underlying the behavioral effects of clinically used nicotinic acetylcholine receptor agonists have not been fully established. OBJECTIVE:Drug discrimination was used to compare receptor mechanisms underlying the effects of smoking cessation aids. METHODS:Separate groups of male C57BL/6J...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3037-5
更新日期:2013-07-01 00:00:00