Abstract:
RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a monoamine uptake blocker would block behavioral effects of MA related to its abuse. OBJECTIVE:RTI 111, a newly synthesized 3-phenyltropane analog with high affinity for the dopamine, norepinephrine, and serotonin transporters, was evaluated alone and in combination with MA for its ability to block the reinforcing and discriminative stimulus effects of MA in rhesus monkeys. METHODS:RTI 111 (0.0003-0.03 mg/kg, i.v.) was made available to four rhesus monkeys for self-administration under a fixed-ratio 25 (FR 25) schedule of reinforcement. RTI 111 (0.01-0.1 mg/kg, i.m.) was also administered as a pretreatment (15 min prior) to four monkeys self-administering MA (0.0-0.3 mg/kg per injection, i.v.) on a progressive-ratio schedule of reinforcement. MA (0.01-1.0 mg/kg, i.m.), RTI 111 (0.001-0.1 mg/kg, i.m.), or the combination of MA and RTI 111 were administered to four monkeys trained to discriminate (+)-amphetamine (AMPH; 1.0 or 1.7 mg/kg, intragastric) from saline. RESULTS:When RTI 111 was made available for self-administration under an FR 25 schedule it functioned as a positive reinforcer in all four monkeys tested. When RTI 111 was given as a pretreatment to monkeys self-administering MA under a progressive-ratio schedule, the MA dose-response function shifted to the left and down. When RTI 111 or MA were given to monkeys trained to discriminate AMPH from saline, full AMPH-like responding was observed for both drugs. Given in combination, RTI 111 shifted the MA dose-response function to the left. CONCLUSIONS:These data suggest that RTI 111 is behaviorally similar to traditional psychomotor stimulants that act at the DA transporter and that it increases, rather than blocks, the behavioral potency of MA.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ranaldi R,Anderson KG,Carroll FI,Woolverton WLdoi
10.1007/s002130000602subject
Has Abstractpub_date
2000-12-01 00:00:00pages
103-10issue
1eissn
0033-3158issn
1432-2072journal_volume
153pub_type
杂志文章abstract::Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP. This study was undertaken to assess the effect of chronic in vivo infusion of forskolin on noradrene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432514
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as pot...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-018-4931-7
更新日期:2018-08-01 00:00:00
abstract::The purpose of this study was to compare the subchronic, low-dose effects of clozapine with those of olanzapine in a learned behavioral task previously shown to distinguish between clozapine and haloperidol with acute and subchronic treatment regimes. Rats were trained to use a single forelimb to press a force-recordi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050363
更新日期:1997-08-01 00:00:00
abstract::The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence". ...
journal_title:Psychopharmacology
pub_type: 已发布勘误
doi:10.1007/s00213-020-05673-y
更新日期:2020-11-01 00:00:00
abstract::The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426529
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0551-8
更新日期:2006-12-01 00:00:00
abstract::Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050811
更新日期:1999-01-01 00:00:00
abstract::The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244001
更新日期:1990-01-01 00:00:00
abstract::EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244335
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1867-y
更新日期:2010-07-01 00:00:00
abstract::NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246046
更新日期:1995-05-01 00:00:00
abstract::The concentration of kynurenine in plasma from depressed patients and control subjects has been measured using a sensitive and specific method. The levels of kynurenine in the plasma of depressed patients and controls are not significantly different and are not influenced by age or sex. The severity of affective distu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00426632
更新日期:1978-12-08 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212765
更新日期:1988-01-01 00:00:00
abstract::The effects of various psychomotor stimulant drugs and drugs outside this class were examined on the efficacy of stimuli previously paired with reinforcement or reward (conditioned reinforcers, CR) in controlling responding. Pipradrol (5-45 mumol/kg), d-amphetamine (1.25-15.0 mumol/kg), and the cocaine analogues WIN 3...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427952
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:It has been reported that in panic disorder (PD), tryptophan depletion enhances the vulnerability to experimentally induced panic, while the administration of serotonin precursors blunts the response to challenges. OBJECTIVES:Using a high-dose carbon dioxide (CO(2)) challenge, we aimed to investigate the eff...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2177-8
更新日期:2011-06-01 00:00:00
abstract::The uptake of 3H-5-HT in synaptosomes from rat brains was investigated. Addition of DA or NA had only a slight or no effect on the uptake. When the uptake into NA and DA neurons was inhibited by the addition of high concentrations of NA and DA, the uptake of 3H-5-HT was unchanged. This was also found after destruction...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429172
更新日期:1978-12-15 00:00:00
abstract:RATIONALE:Toluene exposure during brain growth spurt has been shown to elevate the seizure susceptibility induced by N-methyl-D: -aspartate (NMDA). In the present study, behavioral responses to NMDA antagonists were studied to determine whether neonatal toluene exposure produces residual deficits in the NMDA glutamater...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0137-x
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0521-1
更新日期:2007-04-01 00:00:00
abstract:RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3840-7
更新日期:2015-06-01 00:00:00
abstract:RATIONALE:The present series of experiments was conducted in order to assess the nature of dopaminergic modulation of the acoustic startle response using agonists and antagonists specific for dopamine D1 and D2 receptors. OBJECTIVES:The objective of the present study was to demonstrate an enhancement of the acoustic s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051020
更新日期:1999-06-01 00:00:00
abstract::Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433058
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050992
更新日期:1999-05-01 00:00:00
abstract::In a test of conditioned punishment, saline-treated controls showed a moderate bias in responding away from a lever producing a response-contingent auditory conditioned stimulus (CS) that had been paired with mild footshock during training and towards a lever producing a neutral auditory CS. Systemic treatment with th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050174
更新日期:1997-01-01 00:00:00
abstract:RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4356-0
更新日期:2016-08-01 00:00:00
abstract::The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247394
更新日期:1996-05-01 00:00:00
abstract::Risperidone, a new antipsychotic agent, was studied for its effects on spontaneous motor activity in rats in comparison with haloperidol. Motor activity was recorded via the optical scanning technique (horizontal and vertical activity) and via a recently developed technique based on the piezo-electric principle which,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172961
更新日期:1988-01-01 00:00:00
abstract::Exposure to 10 min of footshock stress (1 mA; 0.5 s on, with a mean off period of 40 s) reinstated heroin-seeking behavior in heroin-experienced, drug-free rats after many sessions of extinction and up to 6 weeks after last exposure to heroin. In reinstating the behavior, the footshock mimicked the effect of a non-con...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246300
更新日期:1995-06-01 00:00:00
abstract::Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179193
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1100-4
更新日期:2008-05-01 00:00:00
abstract::Chronic administration of the benzodiazepine (BZ) receptor agonist chlordiazepoxide (CDP) produced tolerance to its motor-impairing effects but little or no tolerance to its hypothermic effects or to its amnesic effects in the radial arm maze. Male Sprague-Dawley rats were pretreated for 14 days with CDP (25 mg/kg, b....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244749
更新日期:1994-06-01 00:00:00