Abstract:
:The concentration of kynurenine in plasma from depressed patients and control subjects has been measured using a sensitive and specific method. The levels of kynurenine in the plasma of depressed patients and controls are not significantly different and are not influenced by age or sex. The severity of affective disturbance was not related to plasma kynurenine levels in depressed patients. Clinical outcome could not be accurately predicted by measurement of plasma kynurenine levels. Amitriptyline did not significantly increase plasma kynurenine concentration in vivo, whereas lithium and mianserin did have a significant effect. These results are discussed with reference to known abnormalities of tryptophan metabolism in depressive illness and in particular to the 5-hydroxytryptamine uptake characteristics of blood platelets in depressive patients.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wood K,Harwood J,Coppen Adoi
10.1007/BF00426632subject
Has Abstractpub_date
1978-12-08 00:00:00pages
263-6issue
3eissn
0033-3158issn
1432-2072journal_volume
59pub_type
临床试验,杂志文章abstract::A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00430491
更新日期:1976-11-10 00:00:00
abstract:RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05558-0
更新日期:2020-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245291
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Drug addiction is a chronically relapsing disorder characterised by compulsive drug use and loss of control over drug intake. Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear. OBJECTIVES:This study aims to investigate the s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2558-z
更新日期:2012-01-01 00:00:00
abstract:RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1583-y
更新日期:2004-01-01 00:00:00
abstract::The 2-[14C]deoxyglucose method was used to compare the effects of the acute administration of cocaine by two different routes, intravenous and intraperitoneal, on rates of local cerebral glucose utilization in freely moving rats. Doses were initially chosen on the basis of their ability to elicit equivalent increases ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244931
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1201-0
更新日期:2008-10-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246154
更新日期:1995-05-01 00:00:00
abstract:RATIONALE:Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3584-4
更新日期:2014-11-01 00:00:00
abstract::The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00441937
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0010-y
更新日期:2005-09-01 00:00:00
abstract:RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-019-05223-1
更新日期:2019-07-01 00:00:00
abstract::Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-indu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432756
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246286
更新日期:1996-01-01 00:00:00
abstract:RATIONALE:Cognitive processes underlying drug use have typically been assessed in laboratory settings. More detailed and ecologically valid data may be possible if assessments were conducted in an ecological momentary assessment (EMA) setting. OBJECTIVES:We evaluated the feasibility and utility of administering a reac...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-1006-6
更新日期:2008-03-01 00:00:00
abstract:RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2032-3
更新日期:2011-02-01 00:00:00
abstract::Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00449124
更新日期:1982-01-01 00:00:00
abstract::The effects of single and repeated electroconvulsive treatment (ECT) on beta-endorphin (beta-EP), cortisol, growth hormone (GH) and prolactin (Prl) plasma levels were investigated in nine depressed patients. Blood samples were monitored a day before ECT, the day of the first and sixth ECT (0, 30, 60 and 90 min after s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02439598
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464579
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possi...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0025-4
更新日期:2005-08-01 00:00:00
abstract::It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735892
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1526-3
更新日期:2009-07-01 00:00:00
abstract:RATIONALE:The influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established. OBJECTIVE:This work analyzes the sexual effects of dopamine (DA) receptor activation in the mPO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5142-y
更新日期:2019-04-01 00:00:00
abstract:RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1238-0
更新日期:2009-04-01 00:00:00
abstract::After publication of this paper, the authors determined an error in Fig. 2C. ...
journal_title:Psychopharmacology
pub_type: 已发布勘误
doi:10.1007/s00213-019-05269-1
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1921-8
更新日期:2004-12-01 00:00:00
abstract::Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varying degrees of protein binding. Using a mass fragmentographic ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431102
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:The aversive effects of ∆(9)-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3970-6
更新日期:2015-09-01 00:00:00
abstract:RATIONALE:Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients su...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1903-y
更新日期:2011-02-01 00:00:00
abstract::In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244140
更新日期:1990-01-01 00:00:00