Effect of muscimol, a central GABA receptor agonist, on the catalepsy, striatal homovanillic acid increase, and analgesia induced by pilocarpine in rats.

abstract：:We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...

journal_title：Psychopharmacology

authors： Küfferle B,Tauscher J,Asenbaum S,Vesely C,Podreka I,Brücke T,Kasper S

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：:Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...

journal_title：Psychopharmacology

authors： Tye NC,Horsman L,Wright FC,Pullar IA

更新日期：1979-05-15 00:00:00

abstract：RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...

journal_title：Psychopharmacology

authors： Crawford AA,Lewis S,Nutt D,Peters TJ,Cowen P,O'Donovan MC,Wiles N,Lewis G

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investiga...

journal_title：Psychopharmacology

authors： Jackson A,Alkhlaif Y,Papke RL,Brunzell DH,Damaj MI

更新日期：2019-12-01 00:00:00

abstract：:The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cerebral cortex, corpus striatum, and hypothalamus was investigated in comparison with several psychotropic drugs, ...

journal_title：Psychopharmacology

authors： Placheta P,Singer E,Kriwanek W,Hertting G

更新日期：1976-08-17 00:00:00

abstract：RATIONALE:Although environmental enrichment renders rats more sensitive to the neurobehavioral effects of acute amphetamine, a previous study found that enriched rats self-administer less amphetamine than isolated rats at a low unit dose (0.03 mg/kg per infusion). In that study, however, acquisition of self-administrat...

journal_title：Psychopharmacology

authors： Green TA,Gehrke BJ,Bardo MT

更新日期：2002-08-01 00:00:00

abstract：:Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. This study examined the effects o...

journal_title：Psychopharmacology

authors： George FR,Porrino LJ,Ritz MC,Goldberg SR

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...

journal_title：Psychopharmacology

authors： Sommer IE,Oranje B,Ramsey NF,Klerk FA,Mandl RC,Westenberg HG,Kahn RS

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Stimulation of central beta(2) adrenergic receptors produces antidepressant-like effects on behavior. At present, it is not known what brain sites are involved in mediating such effects, although some recent evidence suggests the importance of the dorsal hippocampus. OBJECTIVE:Experiments were carried out to...

journal_title：Psychopharmacology

authors： Zhang HT,Huang Y,O'Donnell JM

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity...

journal_title：Psychopharmacology

authors： Andreasen JT,Nielsen EO,Redrobe JP

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...

journal_title：Psychopharmacology

authors： Newman EL,Chu A,Bahamón B,Takahashi A,Debold JF,Miczek KA

更新日期：2012-11-01 00:00:00

abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

journal_title：Psychopharmacology

authors： van der Laan JW,Weick G,Hillen FC

更新日期：1983-01-01 00:00:00

abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...

journal_title：Psychopharmacology

authors： Heal DJ,Frankland AT,Gosden J,Hutchins LJ,Prow MR,Luscombe GP,Buckett WR

更新日期：1992-01-01 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...

journal_title：Psychopharmacology

authors： Ferland CL,Reichel CM,McGinty JF

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight an...

journal_title：Psychopharmacology

authors： Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe C

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...

journal_title：Psychopharmacology

authors： Amato JN,Marie S,Lelong-Boulouard V,Paillet-Loilier M,Berthelon C,Coquerel A,Denise P,Bocca ML

更新日期：2013-07-01 00:00:00

abstract：:Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1...

journal_title：Psychopharmacology

authors： McNair DM,Barrett JE

更新日期：1979-10-01 00:00:00

abstract：:The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 day...

journal_title：Psychopharmacology

authors： Shaham Y

更新日期：1993-01-01 00:00:00

abstract：:This study tested placebo responses in psychomotor performance when caffeine or alcohol was expected. Fifty male university students were assigned to one of four placebo groups or to a no-treatment control group. Two groups received placebo caffeine and two received placebo alcohol. Subjects performed 12 trials on a p...

journal_title：Psychopharmacology

authors： Fillmore MT,Mulvihill LE,Vogel-Sprott M

更新日期：1994-07-01 00:00:00

abstract：RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...

journal_title：Psychopharmacology

authors： Suhara T,Okauchi T,Sudo Y,Takano A,Kawabe K,Maeda J,Kapur S

更新日期：2002-02-01 00:00:00

abstract：RATIONALE:Stress experience during adolescence has been linked to the development of psychiatric disorders in adulthood, many of which are associated with impairments in prefrontal cortex function. OBJECTIVE:The current study was designed to determine the immediate and enduring effects of repeated social stress on a p...

journal_title：Psychopharmacology

authors： Snyder KP,Barry M,Valentino RJ

更新日期：2015-01-01 00:00:00

abstract：:The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...

journal_title：Psychopharmacology

authors： Batra S,Biörklund A

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

journal_title：Psychopharmacology

authors： Cardoso C,Ellenbogen MA,Linnen AM

更新日期：2012-04-01 00:00:00

abstract：:The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

journal_title：Psychopharmacology

authors： Turski L,Turski W,Czuczwar SJ,Kleinrok Z

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...

journal_title：Psychopharmacology

authors： Kohut SJ,Bergman J

更新日期：2016-07-01 00:00:00

abstract：:The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects as measured by resp...

journal_title：Psychopharmacology

authors： Shannon HE,Holtzman SG

更新日期：1976-11-10 00:00:00

abstract：RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm part...

journal_title：Psychopharmacology

authors： Morrison MF,Ceesay P,Gantz I,Kaufman KD,Lines CR

更新日期：2010-04-01 00:00:00

abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...

journal_title：Psychopharmacology

authors： Harkin A,Morris K,Kelly JP,O'Donnell JM,Leonard BE

更新日期：2001-03-01 00:00:00