Abstract：
RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investigate the impact of α7 nAChR pharmacological modulation on nicotine conditioned place preference (CPP) in mice by using positive allosteric modulators (PAMs) and a silent agonist. METHODS:The effect of the orthosteric α7 nAChR full agonist PNU282987 (1.3 and 9 mg/kg, s.c.), Type I α7 PAM NS1738 (1 and 10 mg/kg; i.p.), the Type II α7 PAM PNU120596 (0.3, 1, and 3 mg/kg, i.p.), and the α7 silent agonist NS6740 (1 and 3 mg/kg, i.p) on nicotine CPP was measured in mice. Mice were conditioned with either saline or nicotine (0.5 mg/kg) for 3 days in the CPP paradigm. RESULTS:The α7 full orthosteric agonist PNU282987 and the Type II α7 nAChR PAM PNU120596 reduced nicotine CPP, while the silent agonist NS6740 and Type I PAM NS1738 had no effect. The effects of PNU282987 and PNU120596 did not have an effect on morphine CPP. CONCLUSIONS:Taken together, our results suggest that modulation of the α7 nAChR can play important roles in nicotine CPP in mice. In addition, the Type II α7 nAChR PAM PNU120596 attenuated nicotine reward suggesting that endogenous acetylcholine/choline tone is sufficient to reduce nicotine CPP. These findings highlight a beneficial effect of using α7 nAChR PAMs in nicotine reward.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Jackson A,Alkhlaif Y,Papke RL,Brunzell DH,Damaj MIdoi
10.1007/s00213-019-05331-ysubject
Has Abstractpub_date
2019-12-01 00:00:00pages
3593-3599issue
12eissn
0033-3158issn
1432-2072pii
10.1007/s00213-019-05331-yjournal_volume
236pub_type
杂志文章abstract：RATIONALE:Schizophrenia is characterized by a large variety of cognitive symptoms, among which information processing deficits have been extensively studied. So far, these aspects have been found to be remarkably stable and effective treatment is still lacking. Traditionally, information processing is subdivided into p...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-003-1684-7
更新日期：2004-06-01 00:00:00
abstract：:The aim of this study was to evaluate the effect on the activity of the hypothalamic-pituitary dopaminergic system of two new atypical antipsychotic drugs: the ergoline derivative SDZ HDC-912, which is a dopamine (DA) D2 receptor partial agonist; and the quinolinone derivative OPC-4392, which acts as an agonist at pre...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02246969
更新日期：1993-01-01 00:00:00
abstract：:The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442252
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age. OBJECTIVES:The present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3417-x
更新日期：2014-04-01 00:00:00
abstract：:Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-015-3968-0
更新日期：2015-11-01 00:00:00
abstract：RATIONALE:The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. OBJECTIVE:The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. MATE...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0639-1
更新日期：2007-03-01 00:00:00
abstract：RATIONALE:Animal models of alcohol-seeking are useful for understanding alcohol addiction and for treatment development, but throughput in these models is limited by the extensive pretraining required to overcome the aversive taste of ethanol. Work by Augier et al. (Psychopharmacology 231: 4561-4568, 2014) indicates th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4824-1
更新日期：2018-04-01 00:00:00
abstract：:The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246154
更新日期：1995-05-01 00:00:00
abstract：:Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00181243
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1313-x
更新日期：2003-09-01 00:00:00
abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000630
更新日期：2001-03-01 00:00:00
abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050711
更新日期：1998-10-01 00:00:00
abstract：:The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244999
更新日期：1994-05-01 00:00:00
abstract：RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3030-z
更新日期：2013-07-01 00:00:00
abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433261
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. OBJECTIVE:The present study com...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5036-z
更新日期：2018-11-01 00:00:00
abstract：:In a randomised, double-blind, parallel groups study, 40 patients referred for surgical removal of impacted third molars received either (a) temazepam 40 mg orally followed at 35 min by IV saline or (b) oral placebo followed by IV diazepam 10 mg (Diazemuls). Patients were divided into High-Anxious and Low-Anxious grou...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00652245
更新日期：1986-01-01 00:00:00
abstract：:Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was admin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02805971
更新日期：1996-09-01 00:00:00
abstract：RATIONALE:While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1081-7
更新日期：2002-06-01 00:00:00
abstract：:Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050811
更新日期：1999-01-01 00:00:00
abstract：:This study examined the effects of intrahippocampal injections of scopolamine (a muscarinic antagonist drug) on performance of a working-memory task (contingently reinforced T-maze alternation) and a reference-memory task (visual discrimination) by the same rats in the same maze. Rats in the first shipment were traine...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427569
更新日期：1983-01-01 00:00:00
abstract：:Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00422418
更新日期：1981-01-01 00:00:00
abstract：:The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050757
更新日期：1998-11-01 00:00:00
abstract：:Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00555210
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0138-9
更新日期：2005-11-01 00:00:00
abstract：RATIONALE:Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs. OBJECTIVE:To compare the effects of carbamazepine, remacemide, and placebo on actual driving performance during a 12-day i...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130100898
更新日期：2002-01-01 00:00:00
abstract：RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2082-6
更新日期：2011-04-01 00:00:00
abstract：RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0969-7
更新日期：2008-02-01 00:00:00
abstract：RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4427-2
更新日期：2016-12-01 00:00:00
abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3713-0
更新日期：2015-02-01 00:00:00
