Neuroendocrine profile of SDZ HDC-912 and OPC-4392, two new atypical antipsychotic drugs, in schizophrenic patients.

abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1977-03-16 00:00:00

abstract：RATIONALE:Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson's disease (PD). These paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the baseline dopamine l...

journal_title：Psychopharmacology

authors： Vo A,Seergobin KN,Morrow SA,MacDonald PA

更新日期：2016-07-01 00:00:00

abstract：:Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...

journal_title：Psychopharmacology

authors： Chopin P,Briley M

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...

journal_title：Psychopharmacology

authors： Zhang H,Lee ZX,Qiu A

更新日期：2020-10-01 00:00:00

abstract：:Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...

journal_title：Psychopharmacology

authors： Keenan RM,Hatsukami DK,Pickens RW,Gust SW,Strelow LJ

更新日期：1990-01-01 00:00:00

abstract：:The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

journal_title：Psychopharmacology

authors： Riffee WH,Gerald MC

更新日期：1977-01-31 00:00:00

abstract：RATIONALE:Rolipram, an inhibitor of cyclic AMP phosphodiesterase (PDE4) produces discriminative stimulus effects in rats. These effects may be related to a wide range of central nervous system effects described previously. OBJECTIVE:The purposes of the present study were to: (i) assess the specificity of the discrimin...

journal_title：Psychopharmacology

authors： Makhay MM,Houslay MD,O'Donnell JM

更新日期：2001-11-01 00:00:00

abstract：RATIONALE:The motivational impetuses underlying self-administration of cocaine and other drugs of abuse are not fully understood. One emerging factor is affect. Both positive and negative affective states have been hypothesized to influence drug seeking and drug taking. In parallel, it has been posited that the ultraso...

journal_title：Psychopharmacology

authors： Barker DJ,Root DH,Ma S,Jha S,Megehee L,Pawlak AP,West MO

更新日期：2010-09-01 00:00:00

abstract：:Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....

journal_title：Psychopharmacology

authors： Mumford L,Teixeira AR,Kumar R

更新日期：1979-04-25 00:00:00

abstract：:In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...

journal_title：Psychopharmacology

authors： Wiles DH,McCreadie RG,Whitehead A

更新日期：1990-01-01 00:00:00

abstract：:The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species. ...

journal_title：Psychopharmacology

authors： Borsini F,Meli A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...

journal_title：Psychopharmacology

authors： Yap JJ,Chartoff EH,Holly EN,Potter DN,Carlezon WA Jr,Miczek KA

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Although both contain behaviourally significant concentrations of caffeine, tea is commonly perceived to be a less stimulating drink than coffee. At least part of the explanation for this may be that theanine, which is present in tea but not coffee, has relaxing effects. There is also some evidence that thean...

journal_title：Psychopharmacology

authors： Rogers PJ,Smith JE,Heatherley SV,Pleydell-Pearce CW

更新日期：2008-01-01 00:00:00

abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...

journal_title：Psychopharmacology

authors： DeVane CL,Laizure SC,Cameron DF

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...

journal_title：Psychopharmacology

authors： Tamminga CA,Littman RL,Alphs LD,Chase TN,Thaker GK,Wagman AM

更新日期：1986-01-01 00:00:00

abstract：:This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to incr...

journal_title：Psychopharmacology

authors： Rubinow DR,Post RM,Gold PW,Ballenger JC,Reichlin S

更新日期：1985-01-01 00:00:00

abstract：:A total of 97 patients, who participated in two studies on the relationship between the clinical effect and plasma levels of imipramine and clomipramine, were examined for improvement curves by use of weekly ratings on the Hamilton Depression Scale (HDS). Although we confirmed that our six-item HDS subscale, in contra...

journal_title：Psychopharmacology

authors： Bech P,Allerup P,Reisby N,Gram LF

更新日期：1984-01-01 00:00:00

abstract：:A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...

journal_title：Psychopharmacology

authors： Grun EA,Pauly JR,Collins AC

更新日期：1992-01-01 00:00:00

abstract：:The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups desi...

journal_title：Psychopharmacology

authors： Curran HV,Sakulsriprong M,Lader M

更新日期：1988-01-01 00:00:00

abstract：:The mood-altering properties of amphetamine (AMPH) in humans (euphoria and depression) have been postulated to be related to the increases and decreases respectively which this drug produces in the sensitivity of the reward system of the brain. The present study further evaluated this relationship by testing the effec...

journal_title：Psychopharmacology

authors： Leith NJ,Barrett RJ

更新日期：1980-01-01 00:00:00

abstract：:Self-injection of phencyclidine HCI (PCP) and four of its analogues was examined in baboons. IV injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Self-injection p...

journal_title：Psychopharmacology

authors： Lukas SE,Griffiths RR,Brady JV,Wurster RM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...

journal_title：Psychopharmacology

authors： Buchmann AF,Zohsel K,Blomeyer D,Hohm E,Hohmann S,Jennen-Steinmetz C,Treutlein J,Becker K,Banaschewski T,Schmidt MH,Esser G,Brandeis D,Poustka L,Zimmermann US,Laucht M

更新日期：2014-08-01 00:00:00

abstract：:When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...

journal_title：Psychopharmacology

authors： Isseroff A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...

journal_title：Psychopharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2000-02-01 00:00:00

abstract：:The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...

journal_title：Psychopharmacology

authors： Foltin RW,Evans SM

更新日期：1997-08-01 00:00:00

abstract：:In order to study trends in smoking withdrawal symptoms, 35 participants in a smoking cessation clinic completed four questionnaires daily for 2 weeks. The questionnaire dealt with a variety of symptoms which a factor analysis showed could be grouped into four factors: stimulation, desire to smoke, and physical and ps...

journal_title：Psychopharmacology

authors： Shiffman SM,Jarvik ME

更新日期：1976-10-20 00:00:00

abstract：:Two behaviors related to nonreward (omission of water in an enclosure where the rats were habituated to drink) were studied. The time spent licking the bottles during water omission and the time spent drinking during a subsequent 5-min drinking session (water available) were recorded. The drinking session was performe...

journal_title：Psychopharmacology

authors： Soubrié P,Thiébot MH,Simon P,Boissier JR

更新日期：1978-09-15 00:00:00

abstract：:The inferior colliculus is involved in conveying auditory information of an aversive nature to higher cortical structures. Gradual increases in the electrical stimulation of this structure produce progressive aversive responses from vigilance, through freezing, until escape. Recently, we have shown that microinjection...

journal_title：Psychopharmacology

authors： Pandossio JE,Brandão ML

更新日期：1999-03-01 00:00:00