Abstract:
RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's efficacy may vary with level of drinking and/or genetic background. METHODS:The effects of acutely administered topiramate (0, 5, and 10 mg/kg) on ethanol consumption were examined in a large group of ethanol-preferring (P) rats (N = 20) in order to assess the relationship between level of consumption and treatment effect using a two-bottle free-choice paradigm (10% ethanol versus water). We also evaluated the effects of topiramate in two groups of Wistar rats that were given access to ethanol under either the standard two-bottle free-choice paradigm or under conditions that are known to produce higher levels of daily ethanol consumption (i.e. three-bottle free choice). RESULTS:Topiramate treatment produced a modest, but persistent (average of 5 days), reduction in ethanol consumption in P rats, and this effect did not vary with level of consumption. Topiramate did not affect ethanol consumption in either group of Wistar rats. CONCLUSIONS:The results from this study establish in a rodent model that topiramate effectively and persistently reduces ethanol consumption and suggests that its efficacy may depend on genetic vulnerability but not level of drinking.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Breslin FJ,Johnson BA,Lynch WJdoi
10.1007/s00213-009-1683-4subject
Has Abstractpub_date
2010-01-01 00:00:00pages
529-34issue
4eissn
0033-3158issn
1432-2072journal_volume
207pub_type
杂志文章abstract:RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002139900363
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abstract:RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4640-7
更新日期:2017-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432038
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...
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pub_type: 杂志文章
doi:10.1007/s00213-003-1703-8
更新日期:2004-04-01 00:00:00
abstract::The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...
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pub_type: 杂志文章
doi:10.1007/BF00426469
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2693-1
更新日期:2012-09-01 00:00:00
abstract:RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2404-3
更新日期:2012-01-01 00:00:00
abstract::The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431987
更新日期:1979-01-01 00:00:00
abstract::Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427100
更新日期:1981-01-01 00:00:00
abstract::2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
abstract::In the present study a cross-familiarisation conditioned taste aversion (CTA) paradigm was utilized to reveal stimulus resemblance between the selective 5-HT1A agonist 8-OHDPAT and a variety of serotonergic and non-serotonergic drugs. In male mice, a 0.22 mg/kg dose of 8-OHDPAT was used as the reference compound induc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247372
更新日期:1993-01-01 00:00:00
abstract::Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429002
更新日期:1983-01-01 00:00:00
abstract::Growth hormone (hGH) responses to centrally acting dopamine agonists were used as indices of CNS dopaminergic function in order to test hypotheses implicating dopaminergic alteration in the etiopathology of schizophrenia. Apomorphine, a direct acting dopamine receptor agonist, and L-Dopa, an indirect agonist dependent...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426313
更新日期:1976-12-21 00:00:00
abstract::A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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更新日期:2003-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
abstract::Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a withdrawal syndrome...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00187263
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1871-1
更新日期:2004-11-01 00:00:00
abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2501-3
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Impulsivity has been strongly linked to addictive behaviors, but can be operationalized in a number of ways that vary considerably in overlap, suggesting multidimensionality. OBJECTIVE:This study tested the hypothesis that the latent structure among multiple measures of impulsivity would reflect the followin...
journal_title:Psychopharmacology
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更新日期:2016-09-01 00:00:00
abstract:RATIONALE:Pre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI). OBJECTIVE:To establish if the effects of ESC + ARI can be altered by modulating the 5-HT1a receptor. METHODS:Sprague-Dawley male rats received ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05225-z
更新日期:2019-07-01 00:00:00
abstract::Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050663
更新日期:1998-07-01 00:00:00
abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-003-1609-5
更新日期:2004-02-01 00:00:00
abstract::The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427282
更新日期:1976-09-17 00:00:00
abstract:RATIONALE:Aminoadamantanes represent a class of NMDA glutamate receptor antagonists that reduce alcohol consumption and may prevent alcohol-induced neuronal adaptations and side effects. OBJECTIVE:Behavioral specificity of memantine and amantadine on alcohol drinking in a schedule-induced polydipsia (SIP) task was inv...
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更新日期:2006-09-01 00:00:00
abstract::Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
abstract::Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00426799
更新日期:1978-06-15 00:00:00